Skip to main content

Research Repository

Advanced Search

Recent Advances in Diagnosis and Treatment Strategies for Multiple Primary Lung Cancer

Li, Bangsheng; Yang, Zhenghong; Zhao, Yingding; Chen, Ying; Huang, Yunchao

Authors

Bangsheng Li

Zhenghong Yang

Yingding Zhao

Ying Chen

Yunchao Huang



Abstract

As the utilization of computed tomography in lung cancer screening becomes more prevalent in the post-pandemic era, the incidence of multiple primary lung cancer (MPLC) has surged in various countries and regions. Despite the continued application of advanced histologic and sequencing technologies in this research field, the differentiation between MPLC and intrapulmonary metastasis (IM) remains challenging. In recent years, the specific mechanisms of genetic and environmental factors in MPLC have gradually come to light. Lobectomy still predominates in the treatment of MPLC, but the observation that tumor-specific sublobar resection has not detrimentally impacted survival appears to be a viable option. With the evolution of paradigms, the amalgamated treatment, primarily surgical, is an emerging trend. Among these, stereotactic ablative radiotherapy (SABR) and lung ablation techniques have emerged as efficacious treatments for early unresectable tumors and control of residual lesions. Furthermore, targeted therapies for driver-positive mutations and immunotherapy have demonstrated promising outcomes in the postoperative adjuvant phase. In this manuscript, we intend to provide an overview of the management of MPLC based on the latest discoveries.

Citation

Li, B., Yang, Z., Zhao, Y., Chen, Y., & Huang, Y. (2023). Recent Advances in Diagnosis and Treatment Strategies for Multiple Primary Lung Cancer. Chinese Journal of Lung Cancer / Zhongguo Feiyan Zazhi, 26(11), 863-873. https://doi.org/10.3779/j.issn.1009-3419.2023.102.44

Journal Article Type Article
Acceptance Date Nov 1, 2023
Publication Date 2023-11
Deposit Date Jan 31, 2024
Publicly Available Date Jan 31, 2024
Journal Chinese Journal of Lung Cancer
Print ISSN 1009-3419
Publisher Chinese Journal of Lung Cancer
Peer Reviewed Peer Reviewed
Volume 26
Issue 11
Pages 863-873
DOI https://doi.org/10.3779/j.issn.1009-3419.2023.102.44
Keywords Lung neoplasms; Next-generation sequencing; Surgery; Radiation therapy; Ablation; Targeted therapy; Immunotherapy
Publisher URL http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2023.102.44

Files





You might also like



Downloadable Citations