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Autologous Matrix-Induced Chondrogenesis (AMIC) for Osteochondral Defects of the Talus: A Systematic Review

Migliorini, Filippo; Maffulli, Nicola; Bell, Andreas; Hildebrand, Frank; Weber, Christian; Lichte, Philipp

Authors

Filippo Migliorini

Nicola Maffulli

Andreas Bell

Frank Hildebrand

Christian Weber

Philipp Lichte



Abstract

Autologous matrix-induced chondrogenesis (AMIC) has been advocated for the management of talar osteochondral lesions (OCLs). This systematic review, which was conducted according to the PRISMA 2020 guidelines, investigated the clinical and imaging efficacy and safety of the AMIC technique in the management of OCLs of the talus. Only studies investigating AMIC for talar chondral defects that were published in peer-reviewed journals were considered. In September 2022, the following databases were accessed: PubMed, Web of Science, Google Scholar, and Embase. Data on the visual analogue scale (VAS), American Orthopaedic Foot and Ankle Score (AOFAS), Tegner activity scale, and Foot Function Index (FFI) were retrieved. To evaluate the morphological MRI findings, data obtained from the magnetic resonance observation of cartilage repair tissue (MOCART) scores were evaluated. Data on hypertrophy, failures, and revision surgeries were also collected. Data from 778 patients (39% women, 61% men) were collected. The mean length of the follow-up was 37.4 ± 16.1 months. The mean age of the patients was 36.4 ± 5.1 years, and the mean BMI was 26.1 ± 1.6 kg/m2. The mean defect size was 2.1 ± 1.9 cm2. Following the AMIC technique, patients demonstrated an improved VAS (p < 0.001), AOFAS (p < 0.001), and FFI (p = 0.02) score. The MOCART score also improved from the baseline (p = 0.03). No difference was observed in the Tegner score (p = 0.08). No graft delamination and hypertrophy were reported in 353 patients. 7.8% (44 of 564) of patients required revision surgeries, and 6.2% (32 of 515) of patients were considered failures. The AMIC technique could be effective in improving symptoms and the function of chondral defects of the talus.

Citation

Migliorini, F., Maffulli, N., Bell, A., Hildebrand, F., Weber, C., & Lichte, P. (2022). Autologous Matrix-Induced Chondrogenesis (AMIC) for Osteochondral Defects of the Talus: A Systematic Review. Life, 12(11), 1738. https://doi.org/10.3390/life12111738

Journal Article Type Article
Acceptance Date Oct 27, 2022
Online Publication Date Oct 29, 2022
Publication Date Oct 29, 2022
Deposit Date Feb 13, 2024
Journal Life
Print ISSN 2075-1729
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 12
Issue 11
Pages 1738
DOI https://doi.org/10.3390/life12111738
Keywords Paleontology, Space and Planetary Science, General Biochemistry, Genetics and Molecular Biology, Ecology, Evolution, Behavior and Systematics