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The information required by people with inflammatory arthritis to take methotrexate: a mixed-methods systematic review

Logan, Sarah J; Hider, Samantha; Green, Julie; Ryan, Sarah J


Sarah J Logan

Sarah J Ryan


Objectives This mixed-methods systematic review aimed to identify and synthesize knowledge of the characteristics, content, and preferred format of information to support people with inflammatory arthritis (IA) to take methotrexate. Methods A literature search using MEDLINE, The Cochrane Library, Embase, CINAHL, PsychInfo, GreyEU, Web of Science and Open Dissertation was conducted to identify all studies published from 2000 to December 2022. Included studies detailed factors related to methotrexate (MTX) related information needs of people with inflammatory arthritis ≥ 18 years in English. Joanna Briggs Institute Guidelines (JBI) for convergent integrated mixed-methods systematic reviews were followed using validated tools for data extraction and quality. Data was analysed using reflexive thematic analysis. Results Thirteen studies (seven quantitative, two mixed-methods and four qualitative) were included involving 3425 adults, mainly female n = 2434 (71%), age 20–84 years. An overarching theme of a requirement for person-centred care was developed with three interlinking themes: 1: Accepting the need for treatment with MTX, 2: Concerns about taking MTX, 3: A need for tailored information and support. Limitations of the evidence were use of heterogeneous outcome measures and instruments to measure information needs. Conclusion People with IA have individual, multi-faceted information, and support needs about MTX that are often unresolved when a one-size-fits-all approach is used. The findings can inform rheumatology training to support a person-centred approach to identifying and addressing specific needs, concerns and the development of consistent easy-to-understand accessible MTX information.


Logan, S. J., Hider, S., Green, J., & Ryan, S. J. (in press). The information required by people with inflammatory arthritis to take methotrexate: a mixed-methods systematic review. Rheumatology,

Journal Article Type Article
Acceptance Date Dec 21, 2023
Online Publication Date Feb 7, 2024
Deposit Date Feb 19, 2024
Journal Rheumatology
Print ISSN 1462-0324
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Keywords Pharmacology (medical), Rheumatology
Publisher URL