Iodoarene-catalyzed cyclizations of N-propargylamides and β-amidoketones: synthesis of 2-oxazolines

Kamouka, Somaia; Moran, Wesley J.

Abstract

Two complementary iodoarene-catalyzed methods for the preparation of 2-oxazolines are presented. The first involves the cyclization of N-propargylamides and the second involves the cyclization of β-amidoketones. These are proposed to proceed through different mechanisms and have different substrate scopes.

Citation

Kamouka, S., & Moran, W. J. (2017). Iodoarene-catalyzed cyclizations of N-propargylamides and β-amidoketones: synthesis of 2-oxazolines. Beilstein Journal of Organic Chemistry, 13, 1823–1827. https://doi.org/10.3762/bjoc.13.177

• Journal Article Type: Article
• Acceptance Date: Aug 17, 2017
• Online Publication Date: Aug 31, 2017
• Publication Date: Aug 31, 2017
• Deposit Date: Mar 11, 2024
• Journal: Beilstein Journal of Organic Chemistry
• Print ISSN: 1860-5397
• Publisher: Beilstein-Institut
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Pages: 1823–1827
• DOI: https://doi.org/10.3762/bjoc.13.177
• Keywords: amides; catalysis; cyclization; hypervalent iodine; isoxazolines