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Sex differences in trends and in-hospital outcomes of acute myocardial infarction in patients with familial hypercholesterolemia: insights from a large national database.

Rivera, Frederick Berro; Cha, Sung Whoy; Liston, Mara Bernadette; Redula, Sonny; Bantayan, Nathan Ross B.; Shah, Nishant; Mamas, Mamas A.; Volgman, Annabelle Santos; Bantayan, Nathan Ross B; Mamas, Mamas A

Authors

Frederick Berro Rivera

Sung Whoy Cha

Mara Bernadette Liston

Sonny Redula

Nathan Ross B. Bantayan

Nishant Shah

Mamas A. Mamas

Annabelle Santos Volgman

Nathan Ross B Bantayan



Abstract

Sex differences in clinical outcomes following acute myocardial infarction (AMI) are well known. However, data on sex differences among patients with familial hypercholesterolemia (FH) are limited. We aimed to explore sex differences in outcomes of AMI among patients with FH from a national administrative dataset. We utilized the National Inpatient Sample to identify admissions with a primary diagnosis of AMI and a secondary diagnosis of FH. Our primary outcome of interest was in-hospital mortality; secondary outcomes were performance of percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), respiratory complications, use of inotropes, use of mechanical circulatory support (MCS), bleeding complications, transfusion and facility discharge. We adjusted for demographics (model A), comorbidities (model B), and intervention (model C). Between October 2016 and December 2020, 5,714,993 admissions with a primary diagnosis of AMI were identified, of which 3,035 (0.05%) had a secondary diagnosis of FH. In-hospital mortality did not differ between men and women (Model C, adjusted OR = 0.85; 95% CI 0.28-2.60,  = 0.773). There was no sex difference in the secondary outcomes. Despite generally being older and having more comorbidities, women with FH fair equally with men with FH in terms of mortality during AMI admission.

Citation

Rivera, F. B., Cha, S. W., Liston, M. B., Redula, S., Bantayan, N. R. B., Shah, N., …Mamas, M. A. (in press). Sex differences in trends and in-hospital outcomes of acute myocardial infarction in patients with familial hypercholesterolemia: insights from a large national database. Expert Review of Cardiovascular Therapy, 1-8. https://doi.org/10.1080/14779072.2024.2329720

Journal Article Type Article
Acceptance Date Mar 8, 2024
Online Publication Date Mar 12, 2024
Deposit Date Mar 28, 2024
Journal Expert review of cardiovascular therapy
Print ISSN 1477-9072
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Pages 1-8
DOI https://doi.org/10.1080/14779072.2024.2329720
Keywords Sex differences, cardiovascular outcomes, acute myocardial infarction, Sex disparities, familial hypercholesterolemia