Mark Livingston
Macroprolactin over time: Is there any point in rechecking it in people with a persistently elevated serum prolactin?
Livingston, Mark; Hashmi, Syeda F.; Ramachandran, Sudarshan; Laing, Ian; Heald, Adrian
Authors
Syeda F. Hashmi
Sudarshan Ramachandran
Ian Laing
Adrian Heald
Abstract
Objective and Design: Macroprolactinemia may influence the interpretation of serum prolactin levels—a recognised phenomenon since 1981. The degree of macroprolactinaemia over time is less well described. We determined how macroprolactin status (based on polyethylene glycol (PEG) precipitation) varied by analysing serial measurements in hyperprolactinaemic individuals over a period of 9 years. Patients and Measurements: Results from 1810 individuals were included. All serum total prolactin results (measured using Roche Cobas 8000 analyser) were extracted from the laboratory information system for the period 1 January 2012 to 1 April 2021, along with relevant patient demographic/test data. Samples with a macroprolactin screening test performed (on samples with prolactin > 700 miu/L) were included in the main analysis. Results: During the study period, 2782 macroprolactin checks were performed (12.5% of all prolactin tests) in 1810 individuals (599 males/2183 females, median‐age: 35, interquartile range: 25–47, range: 16–93 years). Multiple macroprolactin checks were carried out on 465 patients (1437 measurements) with 94 patients (141 measurements) screening positive (<60% recovery). Only 19 patients (18 female) had at least one result above and one below the 60% screening cut‐off, with 10 of these patients having results close to the 60% cut‐off; in 9 patients, results were clearly different between repeat samples. In seven cases, the adjusted monomeric prolactin showed a potentially clinically significant difference. Conclusions: In this study, only 19/465 patients appeared to change macroprolactin status based on a 60% PEG recovery cut‐off. The majority of these 19 patients were on antipsychotic/antidepressant medication(s) or had a prolactinoma; in only 7 did monomeric prolactin change significantly. This suggests that once macroprolactin status has been determined, clinical decision making is rarely affected by repeating it.
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 5, 2024 |
Online Publication Date | Mar 27, 2024 |
Deposit Date | Apr 8, 2024 |
Publicly Available Date | Apr 8, 2024 |
Journal | Clinical Endocrinology |
Print ISSN | 0300-0664 |
Electronic ISSN | 1365-2265 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 100 |
Issue | 5 |
Pages | 450-458 |
DOI | https://doi.org/10.1111/cen.15051 |
Keywords | macroprolactin, monitoring, longitudinal trend, prolactin |
Files
Macroprolactin over time: Is there any point in rechecking it in people with a persistently elevated serum prolactin?
(965 Kb)
Archive
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0/
Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
Copyright Statement
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search