Opinder Sahota
Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study
Sahota, Opinder; Narayanasamy, Melanie; Bastounis, Anastasios; Paskins, Zoe; Bishop, Simon; Langley, Tessa; Gittoes, Neil; Davis, Sarah; Baily, Ann; Holmes, Moira; Leonardi-Bee, Jo
Authors
Melanie Narayanasamy
Anastasios Bastounis
Zoe Paskins z.paskins@keele.ac.uk
Simon Bishop
Tessa Langley
Neil Gittoes
Sarah Davis
Ann Baily
Moira Holmes
Jo Leonardi-Bee
Abstract
Bisphosphonates are a class of medication commonly used to treat osteoporosis. Alendronate is recommended as the first-line treatment; however, long-term adherence (both treatment compliance and persistence) is poor. Alternative bisphosphonates are available, which can be given intravenously and have been shown to improve long-term adherence. However, the most clinically effective and cost-effective alternative bisphosphonate regimen remains unclear. What is the most cost-effective bisphosphonate in clinical trials may not be the most cost-effective or acceptable to patients in everyday clinical practice.
Report Type | Research Report |
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Acceptance Date | May 1, 2023 |
Publication Date | 2024-04 |
Deposit Date | Apr 22, 2024 |
Publisher | NIHR Journals Library |
DOI | https://doi.org/10.3310/WYPF0472 |
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