Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study

Sahota, Opinder; Narayanasamy, Melanie; Bastounis, Anastasios; Paskins, Zoe; Bishop, Simon; Langley, Tessa; Gittoes, Neil; Davis, Sarah; Baily, Ann; Holmes, Moira; Leonardi-Bee, Jo

Abstract

Bisphosphonates are a class of medication commonly used to treat osteoporosis. Alendronate is recommended as the first-line treatment; however, long-term adherence (both treatment compliance and persistence) is poor. Alternative bisphosphonates are available, which can be given intravenously and have been shown to improve long-term adherence. However, the most clinically effective and cost-effective alternative bisphosphonate regimen remains unclear. What is the most cost-effective bisphosphonate in clinical trials may not be the most cost-effective or acceptable to patients in everyday clinical practice.

Citation

Sahota, O., Narayanasamy, M., Bastounis, A., Paskins, Z., Bishop, S., Langley, T., …Leonardi-Bee, J. (2024). Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study. Secretary of State for Health and Social Care / NIHR

• Report Type: Research Report
• Acceptance Date: May 1, 2023
• Publication Date: 2024-04
• Deposit Date: Apr 22, 2024
• Publisher: NIHR Journals Library
• Pages: 1-169
• DOI: https://doi.org/10.3310/WYPF0472
• Keywords: PERSISTENCE, BISPHOSPHONATE, QUALITATIVE, ADHERENCE, ALENDRONATE, COMPLIANCE, Diphosphonates - therapeutic use, Osteoporotic Fractures - prevention & control, Osteoporosis - drug therapy, Humans, ZOLEDRONATE, MIXED METHODS, IBANDRONATE, Alendronate, INTRA
• Public URL: https://keele-repository.worktribe.com/output/797178
• Publisher URL: https://www.journalslibrary.nihr.ac.uk/hta/WYPF0472#/abstract