The role of ICAM-1 in Plasmodium falciparum cytoadherence

Chakravorty, Srabasti J.; Craig, Alister

Abstract

Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC–endothelial cell interaction and the mechanisms that underlie parasite cytoadherence.

Citation

Chakravorty, S. J., & Craig, A. (2005). The role of ICAM-1 in Plasmodium falciparum cytoadherence. European Journal of Cell Biology, 84(1), 15-27. https://doi.org/10.1016/j.ejcb.2004.09.002

• Journal Article Type: Article
• Acceptance Date: Sep 30, 2004
• Online Publication Date: Dec 1, 2004
• Publication Date: Jan 31, 2005
• Deposit Date: May 14, 2024
• Journal: European Journal of Cell Biology
• Print ISSN: 0171-9335
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 84
• Issue: 1
• Pages: 15-27
• DOI: https://doi.org/10.1016/j.ejcb.2004.09.002
• Public URL: https://keele-repository.worktribe.com/output/827497