Petar M. Seferović
Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases
Seferović, Petar M.; Paulus, Walter J.; Rosano, Giuseppe; Polovina, Marija; Petrie, Mark C.; Jhund, Pardeep S.; Tschöpe, Carsten; Sattar, Naveed; Piepoli, Massimo; Papp, Zoltán; Standl, Eberhard; Mamas, Mamas A.; Valensi, Paul; Linhart, Ales; Lalić, Nebojša; Ceriello, Antonio; Döhner, Wolfram; Ristić, Arsen; Milinković, Ivan; Seferović, Jelena; Cosentino, Francesco; Metra, Marco; Coats, Andrew J.S.
Authors
Walter J. Paulus
Giuseppe Rosano
Marija Polovina
Mark C. Petrie
Pardeep S. Jhund
Carsten Tschöpe
Naveed Sattar
Massimo Piepoli
Zoltán Papp
Eberhard Standl
Mamas Mamas m.mamas@keele.ac.uk
Paul Valensi
Ales Linhart
Nebojša Lalić
Antonio Ceriello
Wolfram Döhner
Arsen Ristić
Ivan Milinković
Jelena Seferović
Francesco Cosentino
Marco Metra
Andrew J.S. Coats
Abstract
The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) has been firmly established; however, the entity of diabetic myocardial disorder (previously called diabetic cardiomyopathy) remains a matter of debate. Diabetic myocardial disorder was originally described as the occurrence of myocardial structural/functional abnormalities associated with T2DM in the absence of coronary heart disease, hypertension and/or obesity. However, supporting evidence has been derived from experimental and small clinical studies. Only a minority of T2DM patients are recognized as having this condition in the absence of contributing factors, thereby limiting its clinical utility. Therefore, this concept is increasingly being viewed along the evolving HF trajectory, where patients with T2DM and asymptomatic structural/functional cardiac abnormalities could be considered as having pre‐HF. The importance of recognizing this stage has gained interest due to the potential for current treatments to halt or delay the progression to overt HF in some patients. This document is an expert consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases. It summarizes contemporary understanding of the association between T2DM and HF and discuses current knowledge and uncertainties about diabetic myocardial disorder that deserve future research. It also proposes a new definition, whereby diabetic myocardial disorder is defined as systolic and/or diastolic myocardial dysfunction in the presence of diabetes. Diabetes is rarely exclusively responsible for myocardial dysfunction, but usually acts in association with obesity, arterial hypertension, chronic kidney disease and/or coronary artery disease, causing additive myocardial impairment.
Citation
Seferović, P. M., Paulus, W. J., Rosano, G., Polovina, M., Petrie, M. C., Jhund, P. S., …Coats, A. J. (in press). Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases. European Journal of Heart Failure, https://doi.org/10.1002/ejhf.3347
Journal Article Type | Article |
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Acceptance Date | Jun 6, 2024 |
Online Publication Date | Jun 19, 2024 |
Deposit Date | Aug 28, 2024 |
Journal | European Journal of Heart Failure |
Print ISSN | 1388-9842 |
Electronic ISSN | 1879-0844 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1002/ejhf.3347 |
Keywords | Diabetic myocardial disorder Type 2 diabetes mellitus Heart failure Cardiac abnormalities Risk assessment Prevention Treatment |
Public URL | https://keele-repository.worktribe.com/output/858847 |
Publisher URL | https://onlinelibrary.wiley.com/doi/10.1002/ejhf.3347 |
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