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Sodium bicarbonate and beta-alanine supplementation:Is combining both better than either alone? A systematic reviewand meta-analysis

Curran-Bowen, Terence; Guedes da Silva, André; Barreto, Gabriel; Buckley, John; Saunders, Bryan


Terence Curran-Bowen

André Guedes da Silva

Gabriel Barreto

Bryan Saunders


This systematic review and meta-analysis aimed to determine the effect of combined beta-alanine (BA) and sodium bicarbonate (SB) supplementation on exercise capacity and performance. Four databases (PubMed, SPORTDiscus, Web Of Science and MEDLINE) were searched using relevant terms for studies involving healthy (e.g. no chronic diseases or conditions) male or female adults of any training status (athletes, physically active and nonathletes) and that investigated BA and SB in isolation and combination at any dose on an exercise outcome. Ten studies, totalling 243 individuals, met the criteria with 12 outcomes for each nutritional supplement. No ergogenic effect was detected in this meta-analysis for BA (SMD = 0.18, 95% CI: -0.06; 0.43, p = 0.13, tau2 = 0, tau = 0, I2 = 0.0%) or SB (SMD = 0.17, 95% CI: -0.08; 0.41, p = 0.16, tau2 = 0, tau = 0, I2 = 0.0%) in isolation. However, there was a beneficial effect for the combination of BA and SB (SMD = 0.32, 95% CI: 0.07; 0.57, p = 0.02, tau2 = 0, tau = 0, I2 = 0.0%). Meta-regression identified no differences between supplementing with BA or SB separately (F = 0.58; p = 0.57). Combining BA and SB improved exercise performance, however, there was no benefit in taking these supplements individually.


Curran-Bowen, T., Guedes da Silva, A., Barreto, G., Buckley, J., & Saunders, B. (2024). Sodium bicarbonate and beta-alanine supplementation:Is combining both better than either alone? A systematic reviewand meta-analysis. Biology of Sport, 41(3), 79-87.

Journal Article Type Review
Acceptance Date Nov 16, 2023
Online Publication Date Jan 2, 2024
Publication Date 2024
Deposit Date Jul 9, 2024
Publicly Available Date Jul 9, 2024
Journal Biology of Sport
Print ISSN 0860-021X
Publisher Termedia Publishing
Peer Reviewed Peer Reviewed
Volume 41
Issue 3
Pages 79-87
Keywords Ergogenic Aids, Fatigue, Nutrition, Sport, Exercise, Performance
Public URL
Publisher URL,78,51825,0,1.html


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Copyright Statement
The final version of this article and all relevant information related to it, including copyrights, can be found on the publisher website.

Curran-Bowen T, da Silva AG, Barreto G et al. Sodium bicarbonate and beta-alanine supplementation:
Is combining both better than either alone? A systematic review and meta-analysis. Biol Sport.

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