The effectiveness of chia seed in improving glycemic status: A systematic review and meta-analysis.

Pam, Pedram; El Sayed, Iman; Asemani, Sanaz; Jamilian, Parsa; Zarezadeh, Meysam; Ghoreishy, Zohreh

Abstract

This systematic review and meta-analysis aims to evaluate the effectiveness of chia seeds in improving glycemic status, including fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and insulin. A comprehensive literature search was conducted on PubMed, Scopus, Web of Science, Cochrane, and Google Scholar up to January 2024. Randomized controlled trials (RCTs) assessing the effect of chia seeds on FBG, HbA1c, and/or insulin that meet our eligibility criteria were included. Version 2 of the Cochrane risk-of-bias tool (RoB2) was used to assess the quality of the included studies. Data were extracted and analyzed using a random-effects model and reported as weighted mean differences (WMD) with 95 % confidence intervals (CI). Subgroup and sensitivity analyses were also performed. The registration number was CRD42023441766. Out of 341 articles retrieved from the initial search, 8 RCTs (with 10 arms) involving 362 participants were included in the meta-analysis. The results showed that chia consumption had no significant effect on FBG (WMD: 0.79 %; 95 % CI: -0.97 to 2.55; p = 0.38), HbA1c (WMD: -0.12 %; 95 % CI: -0.27 to 0.02; p = 0.09), and insulin (WMD:1.23 %; 95 % CI: -1.77 to 4.22; p = 0.42). Chia seed consumption shows no significant impact on FBG, HbA1c, and insulin levels. This study is limited by the small number of studies in the meta-analysis and the significant heterogeneity among them, necessitating further research with larger sample sizes. [Abstract copyright: Copyright © 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.]

Citation

Pam, P., El Sayed, I., Asemani, S., Jamilian, P., Zarezadeh, M., & Ghoreishy, Z. (2024). The effectiveness of chia seed in improving glycemic status: A systematic review and meta-analysis. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 18(6), Article 103065. https://doi.org/10.1016/j.dsx.2024.103065

• Journal Article Type: Article
• Acceptance Date: Jun 19, 2024
• Online Publication Date: Jun 21, 2024
• Publication Date: Jun 24, 2024
• Deposit Date: Jul 15, 2024
• Journal: Diabetes & metabolic syndrome
• Print ISSN: 1871-4021
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 18
• Issue: 6
• Article Number: 103065
• DOI: https://doi.org/10.1016/j.dsx.2024.103065
• Keywords: Glycemic status, Chia seed, And insulin, Glycated hemoglobin (HbA1c), Fasting blood glucose (FBG)
• Public URL: https://keele-repository.worktribe.com/output/875298
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1871402124001267?via%3Dihub