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All Outputs (38)

Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options (2024)
Journal Article
Nunes, M., Bartosch, C., Abreu, M. H., Richardson, A., Almeida, R., & Ricardo, S. (in press). Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options. Cells, 13(9), Article 786. https://doi.org/10.3390/cells13090786

Ovarian cancer is a highly lethal form of gynecological cancer. This disease often goes undetected until advanced stages, resulting in high morbidity and mortality rates. Unfortunately, many patients experience relapse and succumb to the disease due... Read More about Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options.

Ivermectin Augments the Anti-Cancer Activity of Pitavastatin in Ovarian Cancer Cells (2023)
Journal Article
Jawad, M., & Richardson, A. (2023). Ivermectin Augments the Anti-Cancer Activity of Pitavastatin in Ovarian Cancer Cells. Diseases, 11(1), 49 - 49. https://doi.org/10.3390/diseases11010049

We have previously shown that pitavastatin has the potential to be used to treat ovarian cancer, although relatively high doses are likely to be necessary. One solution to this problem is to identify drugs that are synergistic with pitavastatin, ther... Read More about Ivermectin Augments the Anti-Cancer Activity of Pitavastatin in Ovarian Cancer Cells.

Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel (2022)
Journal Article
Ibrahim, S. L., Abed, M. N., Mohamed, G., Price, J. C., Abdullah, M. I., & Richardson, A. (2023). Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel. British Journal of Cancer, 128(5), 896-906. https://doi.org/10.1038/s41416-022-02095-9

Many cancer patients who initially respond to chemotherapy eventually develop chemoresistance, and to address this, we previously conducted a RNAi screen to identify genes contributing to resistance. One of the hits from the screen was branchedcha... Read More about Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel.

Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT) (2020)
Journal Article
Crowley, E., Leung, E., Reynisson, J., & Richardson, A. (2020). Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT). The FEBS Journal, 287(22), 4917-4932. https://doi.org/10.1111/febs.15275

Autophagy plays a role in several human diseases, but each of the current methods to measure autophagy have significant drawbacks. ATG5 and ATG16L1 are regulators necessary for autophagy therefore, drugs which inhibit the interaction of these protein... Read More about Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT).

Screening a library of approved drugs reveals that prednisolone synergizes with pitavastatin to induce ovarian cancer cell death (2019)
Journal Article
Abed, M., Khanim, F., Richardson, A., & Abdullah, M. (2019). Screening a library of approved drugs reveals that prednisolone synergizes with pitavastatin to induce ovarian cancer cell death. Scientific reports, https://doi.org/10.1038/s41598-019-46102-1

The survival rate for patients with ovarian cancer has changed little in the past three decades since the introduction of platinum-based chemotherapy and new drugs are needed. Statins are drugs used for the treatment and prevention of cardiovascular... Read More about Screening a library of approved drugs reveals that prednisolone synergizes with pitavastatin to induce ovarian cancer cell death.

Palmatine from Unexplored Rutidea parviflora Showed Cytotoxicity and Induction of Apoptosis in Human Ovarian Cancer Cells (2019)
Journal Article
Li, W., Johnson-Ajinwo, O., & Richardson, A. (2019). Palmatine from Unexplored Rutidea parviflora Showed Cytotoxicity and Induction of Apoptosis in Human Ovarian Cancer Cells. Toxins, 237 - 237. https://doi.org/10.3390/toxins11040237

Ovarian cancer ranks amongst the deadliest cancers in the gynaecological category of cancers. This research work aims to evaluate in vitro anti-ovarian cancer activities and identify phytochemical constituents of a rarely explored plant speciesRutide... Read More about Palmatine from Unexplored Rutidea parviflora Showed Cytotoxicity and Induction of Apoptosis in Human Ovarian Cancer Cells.

The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing (2018)
Journal Article
Abdullah, M., Jawad, M., Richardson, A., & Wolf, E. (2018). The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing. Cancer Treatment Reviews, 84-89. https://doi.org/10.1016/j.ctrv.2018.06.010

Statins are widely used to treat hypercholesterolaemia. However, by inhibiting the production of mevalonate, they also reduce the production of several isoprenoids that are necessary for the function of small GTPase oncogenes such as Ras. As such, st... Read More about The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing.

Synthesis and Activity of a Novel Autotaxin Inhibitor-Icodextrin Conjugate (2018)
Journal Article
Allin, S., Wallis, J., Bulman Page, P., Mckenzie, M., Jones, S., Elsegood, M., …Hemming, R. (2018). Synthesis and Activity of a Novel Autotaxin Inhibitor-Icodextrin Conjugate. Journal of Medicinal Chemistry, 7942-7951. https://doi.org/10.1021/acs.jmedchem.8b00935

Autotaxin is an extracellular phospholipase D that catalyzes the hydrolysis of lysophosphatidyl choline (LPC) to generate the bioactive lipid lysophosphatidic acid (LPA). Autotaxin has been implicated in many pathological processes relevant to cancer... Read More about Synthesis and Activity of a Novel Autotaxin Inhibitor-Icodextrin Conjugate.

Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells (2018)
Journal Article
Uche, F., McCullagh, J., Claridge, T., Richardson, A., & Li, W. (2018). Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells. Bioorganic and Medicinal Chemistry Letters, 1652-1656. https://doi.org/10.1016/j.bmcl.2018.03.038

Our previous studies demonstrated that cycleanine, a macrocyclic bisbenzylisoquinoline (BBIQ) alkaloid, showed potent anti-ovarian cancer activity via apoptosis induction. Here, we synthesized two novel (aminoalkyl) cycleanine analogues (2 and 3) thr... Read More about Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells.

Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy (2018)
Journal Article
Al-Shakarci, W., Alsuraifi, A., Abed, M., Abdullah, M., Hoskins, C., Richardson, A., & Curtis, A. (2018). Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy. Pharmaceutics, 48. https://doi.org/10.3390/pharmaceutics10020048

Hepatocellular carcinoma is an aggressive form of liver cancer that displays minimal symptoms until its late stages. Unfortunately, patient prognosis still remains poor with only 10% of patients surviving more than five years after diagnosis. Current... Read More about Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy.

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents (2018)
Journal Article
Mbye, H., Richardson, A., Li, W., Horrocks, P., Johnson-Ajinwo, O., & Ullah, I. (2018). The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents. Bioorganic and Medicinal Chemistry Letters, https://doi.org/10.1016/j.bmcl.2018.02.051

Thymoquinone (TQ), 2-isopropyl-5-methyl-1,4-benzoquinone, a natural product isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative activity in vitro against a range of cancers as well as the human malarial para... Read More about The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.

ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells (2017)
Journal Article
De Wolf, E., De Wolf, C., & Richardson, A. (2018). ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells. Oncology Letters, 15(2), 1979-1984. https://doi.org/10.3892/ol.2017.7516

There is considerable interest in redeploying drugs for use in combination with other oncology therapeutics. The single‑agent activity of statins in ovarian cancer has been widely reported, however the drug concentration required to cause cell death... Read More about ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells.

The interplay between TP53 and mevalonate pathway in ovarian cancer (2017)
Journal Article
Abdullah, M., Abed, M., & Richardson, A. (2017). The interplay between TP53 and mevalonate pathway in ovarian cancer. Annals of Oncology, 28(S5), v6. https://doi.org/10.1093/annonc/mdx361.020

Background: TP53 gene is the most commonly mutated tumour suppressor in human malignancies. TP53 is mutated in more than 50% of all human cancers, with over 96% of high-grade serous ovarian cancer displaying changes at this locus. Mutations of TP53 g... Read More about The interplay between TP53 and mevalonate pathway in ovarian cancer.

Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells (2017)
Journal Article
Abed, M., Richardson, A., & Abdullah, M. (2017). Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells. Scientific reports, 8090 -?. https://doi.org/10.1038/s41598-017-08649-9

Only 40% of patients with advanced ovarian cancer survive more than 5 years. We have previously shown that pitavastatin induces regression of ovarian cancer xenografts in mice. To evaluate whether the response of ovarian cancer cells to pitavastatin... Read More about Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells.

Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer (2017)
Journal Article
de Wolf, E., Abdullah, M. I., Jones, S. M., Menezes, K., Moss, D. M., Drijfhout, F., …Richardson, A. (2017). Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer. Scientific reports, https://doi.org/10.1038/s41598-017-05595-4

Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We have previo... Read More about Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer.

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Uche, F. I., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. W. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Planta Medica, 82(S01), https://doi.org/10.1055/s-0036-1596584

Ovarian cancer remains one of the main causes of death in all gynecologic malignancies [1]. Natural products continue to be important sources of clinically approved anti-cancer drugs [2, 3]. Triclisia subcordata Oliv (Menispermeaceae) is a medicinal... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.