All Outputs (45)

Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology (2013)
Journal Article
Maddock, K., & Richardson, A. (2013). Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology. Pharmacy Education, 36 - 39 (4)

Background: Pharmacy education requires an understanding of the fundamental principles of molecular pharmacology. Among these, abstract concepts such as affinity, association and dissociation rates and partial agonism may be difficult to demonstrate... Read More about Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology.

Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions (2013)
Journal Article
Richardson, A., Bracegirdle, L., McLachlan, S. I., & Chapman, S. R. (2013). Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions. American journal of pharmaceutical education, 77(1), 11. https://doi.org/10.5688/ajpe77111

Objective. To determine whether using 3-dimensional (3D) technology to teach pharmacy students about the molecular basis of the interactions between drugs and their targets is more effective than traditional lecture using 2-dimensional (2D) graphics.... Read More about Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions.

Preclinical evaluation of statins as a treatment for ovarian cancer (2013)
Journal Article
Robinson, E., Nandi, M., Wilkinson, L. L., Arrowsmith, D. M., Curtis, A. D., & Richardson, A. (2013). Preclinical evaluation of statins as a treatment for ovarian cancer. Gynecologic Oncology, 129(2), 417-424. https://doi.org/10.1016/j.ygyno.2013.02.003

Objective To evaluate the potential for statins to treat ovarian cancer. Methods The sensitivity of 7 ovarian cancer cell lines to either statins or statins combined with either carboplatin or paclitaxel was assessed using monolayer cultures. Se... Read More about Preclinical evaluation of statins as a treatment for ovarian cancer.

Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells (2012)
Journal Article
Stamelos, V. A., Robinson, E., Redman, C. W., & Richardson, A. (2013). Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells. Gynecologic Oncology, 128(2), 377-382. https://doi.org/10.1016/j.ygyno.2012.11.019

Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. (2012)
Journal Article
Richardson, A., Stamelos, V., & Redman, C. (2012). Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. Journal of Molecular Signaling, 12 - ?. https://doi.org/10.1186/1750-2187-7-12

BH3 mimetics such as ABT-737 and navitoclax bind to the BCL-2 family of proteins and induce apoptosis through the intrinsic apoptosis pathway. There is considerable variability in the sensitivity of different cells to these drugs. Understanding the m... Read More about Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine..