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All Outputs (169)

Methylation of the FGFR2 gene is associated with high birth weight centile in humans (2014)
Journal Article
Haworth, K. E., Farrell, W. E., Emes, R. D., Ismail, K. M. K., Carroll, W. D., Hubball, E., …Fryer, A. A. (2014). Methylation of the FGFR2 gene is associated with high birth weight centile in humans. Epigenomics, 6(5), 477-491. https://doi.org/10.2217/EPI.14.40

Aims: This study examined links between DNA methylation and birth weight centile (BWC), and explored the impact of genetic variation. Materials & methods: Using HumanMethylation450 arrays, we examined candidate gene-associated CpGs in cord blood from... Read More about Methylation of the FGFR2 gene is associated with high birth weight centile in humans.

Measuring vitamin D levels: surrogates are insufficient (2014)
Journal Article
Heald, A. H., Anderson, S. G., Scargill, J. J., Short, A. D., Holland, D., Livingston, M., …Donn, R. P. (2015). Measuring vitamin D levels: surrogates are insufficient. International Journal of Clinical Practice, 69(1), 131-135. https://doi.org/10.1111/ijcp.12505

With the increasing evidence of adverse consequences because of low vitamin D levels on health demand for vitamin D, screening is increasing. The objective of the study was to assess whether parathyroid hormone (PTH) levels/bone profile is suffici... Read More about Measuring vitamin D levels: surrogates are insufficient.

Reduced Testing Frequency for Glycated Hemoglobin, HbA(1c), Is Associated With Deteriorating Diabetes Control (2014)
Journal Article
Driskell, O. J., Holland, D., Waldron, J. L., Ford, C., Scargill, J. J., Heald, A., …Fryer, A. A. (2014). Reduced Testing Frequency for Glycated Hemoglobin, HbA(1c), Is Associated With Deteriorating Diabetes Control. Diabetes Care, 37(10), 2731-2737. https://doi.org/10.2337/dc14-0297

Objective: We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabete... Read More about Reduced Testing Frequency for Glycated Hemoglobin, HbA(1c), Is Associated With Deteriorating Diabetes Control.

Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations (2014)
Journal Article
Glossop, J. R., Emes, R. D., Nixon, N. B., Haworth, K. E., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2014). Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. Epigenetics, 9(9), 1228-1237. https://doi.org/10.4161/epi.29718

Changes to the DNA methylome have been described in patients with rheumatoid arthritis (RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte and B-lymphocyte populations from healthy individuals. Now, using HumanMeth... Read More about Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations.

Daylight robbery: Hospitals admissions for childhood asthma in English regions are inversely associated with hours of sunshine (2014)
Presentation / Conference
Carroll, W., Saunders, A., Ismail, K., Farrell, W., Emes, R., & Fryer, A. (2014, September). Daylight robbery: Hospitals admissions for childhood asthma in English regions are inversely associated with hours of sunshine. Presented at 22nd Annual Congress, Munich, Germany

Background: Vitamin D is implicated in the expression of childhood asthma but it is difficult to pick apart cause and effect from observational data. If lack of vitamin D is secondary to a sedentary lifestyle then weather patterns should not effect a... Read More about Daylight robbery: Hospitals admissions for childhood asthma in English regions are inversely associated with hours of sunshine.

Evaluation of accuracy of mediolateral episiotomy incisions using a training model (2014)
Journal Article
Silf, K., Woodhead, N., Kelly, J., Fryer, A., Kettle, C., & Ismail, K. M. K. (2015). Evaluation of accuracy of mediolateral episiotomy incisions using a training model. Midwifery, 31(1), 197-200. https://doi.org/10.1016/j.midw.2014.08.009

Background: Episiotomy is one of the most commonly performed surgical procedures worldwide. In the UK the use of episiotomy is selective, rather than routine, and a right mediolateral episiotomy (RMLE) is considered standard practice. According to Th... Read More about Evaluation of accuracy of mediolateral episiotomy incisions using a training model.

263. Genome-Wide DNA Methylation Profiling Identifies Distinct Changes in T- and B-Cell Populations from Patients with Rheumatoid Arthritis (2014)
Presentation / Conference
Glossop, J. R., Nixon, N. B., Emes, R. D., Haworth, K. E., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2014, April). 263. Genome-Wide DNA Methylation Profiling Identifies Distinct Changes in T- and B-Cell Populations from Patients with Rheumatoid Arthritis. Paper presented at Rheumatology 2014, Liverpool, UK

Background: DNA methylation is one of several epigenetic mechanisms that impacts on gene expression without underlying changes to the DNA sequence. Recent studies describe changes to the DNA methylome in RA. To date however, no systematic genome-wide... Read More about 263. Genome-Wide DNA Methylation Profiling Identifies Distinct Changes in T- and B-Cell Populations from Patients with Rheumatoid Arthritis.

Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T-and B-lymphocytes from healthy individuals (2013)
Journal Article
Glossop, J. R., Nixon, N. B., Emes, R. D., Haworth, K. E., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2013). Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T-and B-lymphocytes from healthy individuals. Epigenetics, 8(11), 1188-1197. https://doi.org/10.4161/epi.26265

Multiple reports now describe changes to the DNA methylome in rheumatoid arthritis and in many cases have analyzed methylation in mixed cell populations from whole blood. However, these approaches may preclude the identification of cell type-specific... Read More about Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T-and B-lymphocytes from healthy individuals.

Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight (2013)
Journal Article
Haworth, K. E., Farrell, W. E., Emes, R. D., Ismail, K. M. K., Carroll, W. D., Borthwick, H. D., …Fryer, A. A. (2013). Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight. Epigenomics, 5(1), 37-49. https://doi.org/10.2217/EPI.12.72

Aim: Evidence suggests that folic acid intake affects birth weight and that these effects may be mediated via the fetal epigenome. Our previous array data indicate that methylation in human cord blood at gene-specific CpGs is associated with birth we... Read More about Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight.

Antiepileptic drugs and the fetal epigenome (2012)
Journal Article
Emes, R. D., Clifford, H., Haworth, K. E., Farrell, W. E., Fryer, A. A., Carroll, W. D., …KM, I. (2013). Antiepileptic drugs and the fetal epigenome. Epilepsia, 54(1), e16-e19. https://doi.org/10.1111/j.1528-1167.2012.03673.x

Antiepileptic drugs (AEDs) can lower maternal folate and increase maternal homocysteine levels, which are known to affect the methyl cycle and hence DNA methylation levels. The influence of in utero exposure to AEDs on fetal DNA methylation was inves... Read More about Antiepileptic drugs and the fetal epigenome.

Managing demand for laboratory tests: a laboratory toolkit (2012)
Journal Article
Fryer, A. A., & Smellie, W. S. A. (2013). Managing demand for laboratory tests: a laboratory toolkit. Journal of Clinical Pathology, 66(1), 62-72. https://doi.org/10.1136/jclinpath-2011-200524

Healthcare budgets worldwide are facing increasing pressure to reduce costs and improve efficiency, while maintaining quality. Laboratory testing has not escaped this pressure, particularly since pathology investigations cost the National Health Serv... Read More about Managing demand for laboratory tests: a laboratory toolkit.

Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study (2007)
Journal Article
Kapoor, B., Dunlop, C., Wynn-Jones, C., Fryer, A. A., Strange, R. C., & Maffulli, N. (2007). Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study. Journal of Negative Results in BioMedicine, 6, Article 7. https://doi.org/10.1186/1477-5751-6-7

We investigated the association of developmental dysplasia of the hip (DDH) and primary protrusion acetabuli (PPA) with Vitamin D receptor polymorphisms Taq I and Fok I and oestrogen receptor polymorphisms Pvu II and Xba I. 45 patients with DDH and 2... Read More about Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study.

Asthma severity and atopy: how clear is the relationship? (2006)
Journal Article
Carroll, W. D., Lenney, W., Child, F., Strange, R. C., Jones, P. W., Whyte, M. K., …Fryer, A. A. (2006). Asthma severity and atopy: how clear is the relationship?. Archives of Disease in Childhood, 91(5), 405 - 409. https://doi.org/10.1136/adc.2005.088278

BACKGROUND: The relationship between asthma severity and atopy is complex. Many studies have failed to show significant relationships between clinical severity or lung function and markers of atopic sensitisation. AIM: To determine whether increasing... Read More about Asthma severity and atopy: how clear is the relationship?.

Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. (2005)
Journal Article
Carroll, W., Lenney, W., Jones, P., Strange, R., Child, F., Whyte, M., …Fryer, A. (2005). Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35(9), 1155 - 1161. https://doi.org/10.1111/j.1365-2222.2005.02313.x

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investiga... Read More about Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families..

Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. (2005)
Journal Article
Carroll, W., Lenney, W., Child, F., Strange, R., Jones, P., & Fryer, A. (2005). Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatric Allergy and Immunology, 16(1), 32 - 39. https://doi.org/10.1111/j.1399-3038.2005.00249.x

Maternal factors are known to influence the heritability and expression of asthma and atopy. We report the association of maternal, paternal and proband GSTP1 genotype with lung function in 145 Caucasian children with asthma. GSTP1 Val105/Val105 and... Read More about Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma..

Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes (2001)
Journal Article
Luscombe, C. J., French, M. E., Liu, S., Saxby, M. F., Jones, P. W., Fryer, A. A., & Strange, R. C. (2001). Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. British journal of cancer, 85, 1504 - 1509. https://doi.org/10.1054/bjoc.2001.2097

Exposure to ultraviolet radiation may reduce prostate cancer risk, suggesting that polymorphism in genes that mediate host pigmentation will be associated with susceptibility to this cancer. We studied 210 prostate cancer cases and 155 controls to de... Read More about Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes.

Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma (2001)
Journal Article
Hemmingsen, A., Fryer, A. A., Hepple, M., Strange, R. C., & Spiteri, M. A. (2001). Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma. Respiratory Research, 255 -260. https://doi.org/10.1186/rr64

BACKGROUND The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the Ile105-->Val105 substitution are associated with the asthma phenotypes of atopy and bronc... Read More about Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma.

Polymorphisms of apolipoprotein E; outcome and susceptibility in multiple sclerosis (2000)
Journal Article
Weatherby, S., Mann, C., Davies, M., Carthy, D., Fryer, A., Boggild, M., …Hawkins, C. (2000). Polymorphisms of apolipoprotein E; outcome and susceptibility in multiple sclerosis. Multiple Sclerosis, 6(1), 32-36. https://doi.org/10.1191/135245800678827464

Allelic variants of the apolipoprotein E (APOE) gene influence the course of several neurological diseases. In multiple sclerosis the concentration of APOE in cerebrospinal fluid and its intrathecal synthesis is reduced. Specific isoforms of APOE may... Read More about Polymorphisms of apolipoprotein E; outcome and susceptibility in multiple sclerosis.