Skip to main content

Research Repository

Advanced Search

All Outputs (144)

Counting the Lifetime Cost of Obesity: Analysis based on National England Data (2024)
Journal Article
Fryer, A. A., Heald, A., Stedman, M., Stedman, M., Davies, M. B., Rutter, M. K., …Whyte, M. (2024). Counting the Lifetime Cost of Obesity: Analysis based on National England Data. Diabetes, Obesity and Metabolism, 26(4), 1464-1478. https://doi.org/10.1111/dom.15447

Aim
Obesity has a significant impact on all-cause mortality rate and overall health care resource use (HCRU). These outcomes are also strongly linked to age, sex and local deprivation of the population. We aimed to establish the lifetime costs of ob... Read More about Counting the Lifetime Cost of Obesity: Analysis based on National England Data.

Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion (2023)
Journal Article
Holland, D., Fryer, A. A., Stedman, M., Hanna, F. W. F., Duff, C. J., Green, L., …Wu, P. (2023). Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion. Diabetes Therapy, https://doi.org/10.1007/s13300-023-01482-6

Women are on average diagnosed with diabetes mellitus at later age than men but have higher mortality. As the diagnosis of diabetes mellitus is primarily based on HbA1c, the use of a non-specific reference range and cut point for diabetes mellitus th... Read More about Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion.

Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality (2023)
Journal Article
Stedman, M., Whyte, M. B., Laing, I., Fryer, A. A., Torres, B. M., Robinson, A., …Heald, A. H. (2023). Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality. Diabetes/Metabolism Research and Reviews, 39(8), Article e3695. https://doi.org/10.1002/dmrr.3695

Introduction: The standardised mortality rate (SMR) for people with diabetes in England is 1.5–1.7, with differences in outcomes between sexes. There has been little work examining the factors that could have an impact on this or on what may determin... Read More about Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality.

Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome (2023)
Journal Article
Hanna, F., Wu, P., Heald, A., & Fryer, A. (2023). Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome. BMJ, 382, Article e071675. https://doi.org/10.1136/bmj-2022-071675

Gestational diabetes mellitus (GDM) and polycystic ovarian syndrome (PCOS) represent two of the highest risk factors for development of type 2 diabetes mellitus in young women. As these increasingly common conditions generally affect younger women, e... Read More about Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome.

The Utility of Salivary Cortisone in the Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas (2023)
Journal Article
Issa, B. G., Hanna, F. W. F., Fryer, A. A., Ensah, G., Ebere, I., Marshall, D., & Keevil, B. (2023). The Utility of Salivary Cortisone in the Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas. Journal of Clinical Endocrinology and Metabolism, 108(10), e937-e943. https://doi.org/10.1210/clinem/dgad242

BackgroundGuidelines recommend the assessment of cortisol secretion in patients with adrenal incidentalomas (AI) using the overnight dexamethasone suppression test (ONDST). This requires attendance to a health care facility and venepuncture. Alternat... Read More about The Utility of Salivary Cortisone in the Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas.

The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation (2023)
Journal Article
Holland, D., Heald, A. H., Hanna, F. F., Stedman, M., Wu, P., Sim, J., …Fryer, A. A. (2023). The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation. Diabetes Therapy, 14, 691-707. https://doi.org/10.1007/s13300-023-01380-x

INTRODUCTION: Studies show that the COVID-19 pandemic disproportionately affected people with diabetes and those from disadvantaged backgrounds. During the first 6 months of the UK lockdown,?>?6.6 M glycated haemoglobin (HbA1c) tests were missed. We... Read More about The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation.

Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data (2023)
Journal Article
Duce, H. L., Duff, C. J., Zaidi, S., Parfitt, C., Heald, A. H., & Fryer, A. A. (2023). Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data. Bipolar Disorders, 25(5), 402-409. https://doi.org/10.1111/bdi.13298

INTRODUCTION: Blood test monitoring is essential for management of lithium treatment and NICE guidance recommends 6-monthly serum testing of thyroid function. We examined conformity to these guidelines and impact of monitoring outside these intervals... Read More about Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data.

Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time (2022)
Journal Article
Fryer, A. A., Holland, D., Stedman, M., Duff, C. J., Green, L., Scargill, J., …Heald, A. H. (2022). Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time. Journal of Diabetes Research, 2022, 1 - 11. https://doi.org/10.1155/2022/7093707

Aims. We previously showed that the glycated haemoglobin (HbA1c) testing frequency links to diabetes control. Here, we examine the effect of variability in test interval, adjusted for the frequency, on change in HbA1c (delta HbA1c). Materials & Metho... Read More about Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time.

Can we check serum lithium levels less often without compromising patient safety? (2021)
Journal Article
Heald, A. H., Holland, D., Stedman, M., Davies, M., Duff, C. J., Parfitt, C., …Fryer, A. A. (2021). Can we check serum lithium levels less often without compromising patient safety?. BJPsych Open, e18 - ?. https://doi.org/10.1192/bjo.2021.1027

BACKGROUND: Lithium is viewed as the first-line long-term treatment for prevention of relapse in people with bipolar disorder.

AIMS: This study examined factors associated with the likelihood of maintaining serum lithium levels within the recomme... Read More about Can we check serum lithium levels less often without compromising patient safety?.

The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM) (2021)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., McLoughlin, K., Wong, L., …Heald, A. H. (2022). The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). https://doi.org/10.1002/edm2.302

BACKGROUND: Finger prick blood glucose (BG) monitoring remains a mainstay of management in people with type 2 diabetes (T2DM) who take sulphonylurea (SU) drugs or insulin. We recently examined patient experience of BG monitoring in people with type 1... Read More about The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM).

Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital (2021)
Journal Article
Hanna, F. W. F., Hancock, S., George, C., Clark, A., Sim, J., Issa, B. G., …Fryer, A. A. (2022). Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital. Journal of the Endocrine Society, 6(1), https://doi.org/10.1210/jendso/bvab180

Context: Adrenal incidentalomas (AIs) are increasingly being identified during unrelated imaging. Unlike AI clinical management, data on referral patterns in routine practice are lacking. Objective: This work aimed to identify factors associated with... Read More about Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital.

The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval (2021)
Journal Article
Heald, A., Holland, D., Stedman, M., Duff, C. J., Green, L., Scargill, J., …Fryer, A. A. (in press). The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval. Endocrine, https://doi.org/10.1530/endoabs.77.p64

Worldwide guidance advocates regular HbA1c testing for people with diabetes mellitus, usually 2-4/yr. We previously showed that HbA1c testing frequency is linked to outcome in terms of HbA1c control. Here we examine the effect of variability (standar... Read More about The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval.

Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. (2021)
Journal Article
Holland, D., Heald, A. H., Stedman, M., Hanna, F., Wu, P., Duff, C., …Fryer, A. A. (2021). Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. Journal of Clinical Pathology, 76(3), https://doi.org/10.1136/jclinpath-2021-207776

AIMS: The COVID-19 pandemic, and the focus on mitigating its effects, has disrupted diabetes healthcare services worldwide. We aimed to quantify the effect of the pandemic on diabetes diagnosis/management, using glycated haemoglobin (HbA1c) as surrog... Read More about Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis..

Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome (2021)
Journal Article
Kitchen, M., Manzur, A., Fryer, A., & Wu, P. (in press). Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome. Research Square, https://doi.org/10.21203/rs.3.rs-637359/v1

Aims.
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterised by ovarian morphological, systemic biochemical, and menstrual changes. Women with PCOS are at significantly increased risk of raised fasting glucose, impaired gluc... Read More about Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome.

Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years. (2021)
Journal Article
Ward, R. J., Fryer, A. A., Hanna, F. W., Spencer, N., Mahmood, M., Wu, P., …Duff, C. J. (2021). Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years. International Journal of Clinical Practice, e14447 - ?. https://doi.org/10.1111/ijcp.14447

INTRODUCTION: Women with gestational diabetes (GDM) are at greatly increased risk of type 2 diabetes (T2DM). The UK guidance recommends screening for T2DM at around 6 weeks post-partum and annually thereafter. We evaluated conformity to this guidance... Read More about Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years..

Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results (2021)
Journal Article
Michaelidou, M., Yadegarfar, G., Morris, L., Dolan, S., Robinson, A., Naseem, A., …Heald, A. H. (2021). Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results. Cardiovascular Endocrinology & Metabolism, 10(2), 137 - 145. https://doi.org/10.1097/XCE.0000000000000250

Background The short synacthen test (SST) is the most commonly performed investigation to assess adrenal function. Appropriate criteria for when an SST is performed are subject to debate. We investigated how random serum cortisol levels relate to SST... Read More about Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results.