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All Outputs (49)

A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol (2018)
Journal Article
Paskins, Z., Hughes, G., Myers, H., Hughes, E., Hennings, S., Cherrington, A., …Roddy, E. (2018). A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskeletal Disorders, 19, Article 218. https://doi.org/10.1186/s12891-018-2153-0

BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with... Read More about A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol.

Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies (2018)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Mallen, C., Hay, C. A., & Roddy, E. (2018). Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies. Arthritis Research and Therapy, 20, Article 136. https://doi.org/10.1186/s13075-018-1612-1

BACKGROUND: Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hypertension and diuretic use. METHOD... Read More about Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies.

Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. (2018)
Journal Article
Mallen. (2018). Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. Pilot and Feasibility Studies, 93 - ?. https://doi.org/10.1186/s40814-018-0288-2

Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was to test the feasibility and e... Read More about Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care..

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials (2018)
Report
Hay, E., Dziedzic, K., Foster, N., Peat, G., van der Windt, D., Bartlam, B., …Croft, P. (2018). Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. NIHR. PGfAR as project number RP-PG-0407-10386. Secretary of State for Health and Social Care

Background Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based interventions can reduce OA pain and disability. Objectives Th... Read More about Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study (2018)
Journal Article
Mallen, Roddy, Bucknall, Muller, Hider, Helliwell, & Paskins. (2018). Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study. Osteoporosis International, 1659-1664. https://doi.org/10.1007/s00198-018-4491-z

This study aimed to examine fracture risk in patients with late-onset psoriasis. A cohort study was conducted using primary care records from the Clinical Practice Research Datalink. Psoriasis patients had a 10% increased risk of fracture compared to... Read More about Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study.

Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Mamas, Chew-Graham, & Mallen. (2018). Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design. BMJ Open, https://doi.org/10.1136/bmjopen-2017-020926

Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.

Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink (2018)
Journal Article
Muller, S., Hider, S., Machin, A., Stack, R., Hayward, R. A., Raza, K., & Mallen, C. (2019). Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink. Seminars in Arthritis and Rheumatism, 48(5), 815-820. https://doi.org/10.1016/j.semarthrit.2018.06.008

Background Rheumatoid arthritis (RA) has articular and non-articular manifestations. Early, intensive treatment has substantial benefit for both. This requires patients be identified as soon as symptoms develop. Objectives To determine whether s... Read More about Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink.

PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY (2018)
Presentation / Conference
Nakafero, G., Grainge, M., Myles, P., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2018, June). PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY. Poster presented at Annual European Congress of Rheumatology

Background: Autoimmune rheumatic diseases (AIRDs) are associated with an increased risk of influenza and its complications which may be compounded by the use of potent disease modifying anti-rheumatic drugs (DMARDs). In the United Kingdom, seasonal i... Read More about PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY.

AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review (2018)
Presentation / Conference
Hay, C., Prior, J., Scott, I., Raza, K., Hider, S., & Mallen, C. (2018, June). AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review. Paper presented at Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, Netherlands

Background Rheumatoid arthritis (RA) is a common inflammatory condition, affecting 1% of the population and causing pain, stiffness and swelling, leading to significant disability and loss of function[.1 Delays in the diagnosis and treatment of RA ca... Read More about AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review.

How common is depression in patients with polymyalgia rheumatica? (2018)
Journal Article
Mallen, Bucknall, Belcher, & Hider. (2018). How common is depression in patients with polymyalgia rheumatica?. Clinical Rheumatology, 1633 - 1638. https://doi.org/10.1007/s10067-017-3691-9

Depression is common in inflammatory disorders such as rheumatoid arthritis and systemic lupus erythematosus and negatively impacts on outcomes. Given the long-term nature of polymyalgia rheumatica (PMR) and its glucocorticoid treatment, these patien... Read More about How common is depression in patients with polymyalgia rheumatica?.

Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink. (2018)
Journal Article
Mallen. (2018). Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink. Rheumatology, 977 - 981. https://doi.org/10.1093/rheumatology/key013

Objectives: To examine temporal trends in all-cause and cause-specific mortality in RA. Methods: Data from the Clinical Practice Research Datalink were used. Incident RA cases and four age-, sex- and general practice-matched controls were identified... Read More about Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink..

Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy (2018)
Journal Article
Paskins, Mallen, Bucknall, Hider, Muller, Helliwell, & Roddy. (2018). Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy. Canadian Medical Association Journal, E581 -E587. https://doi.org/10.1503/cmaj.170806

BACKGROUND: Previous studies that quantified the risk of fracture among patients with gout and assessed the potential effect of urate-lowering therapy have provided conflicting results. Our study aims to provide better estimates of risk by minimizing... Read More about Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy.

Relationship of anxiety with joint pain and its management: A population survey (2018)
Journal Article
Barnett, L. A., Pritchard, M. G., Edwards, J. J., Afolabi, E. K., Jordan, K. P., Healey, E. L., …Dziedzic, K. S. (2018). Relationship of anxiety with joint pain and its management: A population survey. Musculoskeletal Care, 16(3), 353-362. https://doi.org/10.1002/msc.1243

Objectives The aims of the present study was to examine the associations between the severity of pain and anxiety in a community population reporting joint pain, and to investigate the management of joint pain in the presence of comorbid anxiety.... Read More about Relationship of anxiety with joint pain and its management: A population survey.

A mixed methods exploration of how UK physical therapists address weight loss among individuals with hip osteoarthritis (2018)
Conference Proceeding
Holden, M., Waterfield, J., Whittle, R., Bennell, K., Chesterton, L., Quicke, J., & Mallen, C. (2018). A mixed methods exploration of how UK physical therapists address weight loss among individuals with hip osteoarthritis. . https://doi.org/10.1016/j.joca.2018.02.645

Hip osteoarthritis (OA) is a common painful and disabling condition. Clinical guidelines recommend weight loss as a core treatment for individuals with hip OA who are overweight or obese. However, in the UK, support for weight loss is often lacking.... Read More about A mixed methods exploration of how UK physical therapists address weight loss among individuals with hip osteoarthritis.

Primary care challenges in diagnosing and referring patients with suspected rheumatoid arthritis: a national cross-sectional gp survey (2018)
Journal Article
Hider, & Mallen. (2018). Primary care challenges in diagnosing and referring patients with suspected rheumatoid arthritis: a national cross-sectional gp survey. Rheumatology Advances in Practice, https://doi.org/10.1093/rap/rky012

Objectives National guidelines advocate referring patients with persistent synovitis to rheumatology within 3 working days of presentation to primary care. This infrequently occurs. We aimed to identify modifiable barriers to early referral of suspe... Read More about Primary care challenges in diagnosing and referring patients with suspected rheumatoid arthritis: a national cross-sectional gp survey.

UK-South Asian patients' experiences of and satisfaction toward receiving information about biologics in rheumatoid arthritis (2018)
Journal Article
Mallen. (2018). UK-South Asian patients' experiences of and satisfaction toward receiving information about biologics in rheumatoid arthritis. Patient Preference and Adherence, 489 -497. https://doi.org/10.2147/ppa.s153741

Background: Rheumatoid arthritis (RA) causes painful joint inflammation and is incurable, but treatments control RA. Drug regimens are complex, and patients often do not take their medication as expected. Poor medication adherence can lead to poorly... Read More about UK-South Asian patients' experiences of and satisfaction toward receiving information about biologics in rheumatoid arthritis.

Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., …Mallen, C. D. (2018). Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial. Arthritis Care and Research, 70(12), 1787-1794. https://doi.org/10.1002/acr.23568

OBJECTIVE: To investigate the cost-effectiveness (cost-utility) of introducing general practitioner screening for anxiety and depression in patients consulting with osteoarthritis (OA). METHODS: A cluster-randomised trial-based economic evaluation to... Read More about Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial.