All Outputs (76)

Association of Smoking and Young Cryptogenic Ischemic Stroke (2025)
Journal Article
Ferdinand, P., Bajpai, R., Von Sarnowski, B., Ylikotila, P., Zedde, M., Sarkanen, T., Ryliskiene, K., Martinez-Majander, N., Juhani Tulkki, L., Licenik, R., Kõrv, J., Kõrv, L., Pezzini, A., Catarina Fonseca, A., Martínez-Sánchez, P., Amaya-Pascasio, L., Yeşilot, N., Waje-Andreassen, U., Fromm, A., Huhtakangas, J., …Roffe, C. (2025). Association of Smoking and Young Cryptogenic Ischemic Stroke. Neurology Open Access, 1(1), 1-9. https://doi.org/10.1212/wn9.0000000000000003

Background and Objectives
The incidence of ischemic stroke in the young is increasing and driven by cryptogenic strokes. Smoking is a well-documented risk factor with a high prevalence in young ischemic strokes. We sought to determine the associatio... Read More about Association of Smoking and Young Cryptogenic Ischemic Stroke.

Pre‐hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT ‐2 trial (2024)
Journal Article
Appleton, J. P., Dixon, M., Woodhouse, L. J., Anderson, C. S., Ankolekar, S., Cala, L., England, T. J., Godolphin, P. J., Krishnan, K., Mair, G., Muir, K. W., Potter, J., Price, C. I., Randall, M., Robinson, T. G., Roffe, C., Rothwell, P. M., Sandset, E. C., Saver, J. L., Siriwardena, A. N., …Bath, P. M. (in press). Pre‐hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT ‐2 trial. European Journal of Neurology, 31(11), 1-7. https://doi.org/10.1111/ene.16502

Background and purpose: Ambulance trials assessing interventions in suspected stroke patients will recruit patients with currently active symptoms that will resolve into transient ischaemic attack (TIA). The safety and efficacy of glyceryl trinitrate... Read More about Pre‐hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT ‐2 trial.

Reperfusion treatment in basilar artery occlusion presenting with mild symptoms (2024)
Journal Article
Schwarz, G., Cascio Rizzo, A., Matusevicius, M., Moreira, T., Vilionskis, A., Naldi, A., Martinez-Majander, N., Bigliardi, G., Toni, D., Roffe, C., Agostoni, E. C., & Ahmed, N. (in press). Reperfusion treatment in basilar artery occlusion presenting with mild symptoms. European Stroke Journal, https://doi.org/10.1177/23969873241272517

Introduction:
Endovascular treatment (EVT) improves outcomes for basilar artery occlusion (BAO) with moderate-to-severe symptoms. However, the best treatment for mild symptoms (NIHSS score 0–10 and 0–5) remains unclear. This study compared EVT ± IVT... Read More about Reperfusion treatment in basilar artery occlusion presenting with mild symptoms.

Outcome 1 year after ICH: Data from the Tranexamic acid for IntraCerebral Haemorrhage 2 (TICH-2) trial (2024)
Journal Article
Law, Z. K., Menon, C. S., Woodhouse, L. J., Appleton, J. P., Al-Shahi Salman, R., Robinson, T., Werring, D., Roffe, C., Dineen, R. A., Bath, P. M., & Sprigg, N. (in press). Outcome 1 year after ICH: Data from the Tranexamic acid for IntraCerebral Haemorrhage 2 (TICH-2) trial. European Stroke Journal, https://doi.org/10.1177/23969873241265939

Introduction: The Tranexamic acid for IntraCerebral Haemorrhage-2 (TICH-2) trial reported no significant improvement in death and dependency at day 90 despite reductions in haematoma expansion, early neurological deterioration and early death. Howeve... Read More about Outcome 1 year after ICH: Data from the Tranexamic acid for IntraCerebral Haemorrhage 2 (TICH-2) trial.

The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial. (2024)
Journal Article
Hollingworth, M., Woodhouse, L. J., Law, Z. K., Ali, A., Krishnan, K., Dineen, R. A., Christensen, H., England, T. J., Roffe, C., Werring, D., Peters, N., Ciccone, A., Robinson, T., Członkowska, A., Bereczki, D., Egea-Guerrero, J. J., Ozturk, S., Bath, P. M., Sprigg, N., England, T. J., & Bath, P. M. (in press). The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial. Neurosurgery, 95(3), 605-616. https://doi.org/10.1227/neu.0000000000002961

An important proportion of patients with spontaneous intracerebral hemorrhage (ICH) undergo neurosurgical intervention to reduce mass effect from large hematomas and control the complications of bleeding, including hematoma expansion and hydrocephalu... Read More about The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial..

Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial. (2024)
Journal Article
Coutts, S. B., Ankolekar, S., Appireddy, R., Arenillas, J. F., Assis, Z., Bailey, P., Barber, P. A., Bazan, R., Buck, B. H., Butcher, K. S., Camden, M.-C., Campbell, B., Casaubon, L. K., Catanese, L., Chatterjee, K., Choi, P. M. C., Clarke, B., Dowlatshahi, D., Ferrari, J., Field, T. S., …Hill, M. D. (in press). Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial. Lancet, https://doi.org/10.1016/S0140-6736%2824%2900921-8

Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenectepl... Read More about Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial..

Adult-onset mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): a diagnostic challenge (2024)
Journal Article
Acquaah, J., Ferdinand, P., & Roffe, C. (2024). Adult-onset mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): a diagnostic challenge. BMJ Case Reports, 17(2), Article e256306. https://doi.org/10.1136/bcr-2023-256306

Rare causes of stroke-like presentations can be difficult to diagnose. We report a case of a man in his 40s who first presented with stroke symptoms, but whose clinical course was not typical for a stroke. A detailed investigation of the patient’s me... Read More about Adult-onset mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): a diagnostic challenge.

Correspondence on ‘Comparison of balloon guide catheter versus non-balloon guide catheter for mechanical thrombectomy in patients with distal medium vessel occlusion’ by Orscelik et al (2023)
Journal Article
Gravino, G., Jakobek, W., Nayak, S., Yang, Y., Ranjbar, J., & Roffe, C. (2023). Correspondence on ‘Comparison of balloon guide catheter versus non-balloon guide catheter for mechanical thrombectomy in patients with distal medium vessel occlusion’ by Orscelik et al. Journal of NeuroInterventional Surgery, 16(6), 631-632. https://doi.org/10.1136/jnis-2023-021256

Evaluating methods of detecting and determining the type of urinary incontinence in adults after stroke: A systematic review (2023)
Journal Article
Gordon, C., Davidson, C. E., Roffe, C., Clegg, A., Booth, J., Lightbody, C. E., Harris, C., Sohani, A., & Watkins, C. (in press). Evaluating methods of detecting and determining the type of urinary incontinence in adults after stroke: A systematic review. Neurourology and Urodynamics, 43(2), 364-381. https://doi.org/10.1002/nau.25330

Introduction: Urinary incontinence (UI) affects over half of people with stroke. It is unclear which methods are accurate in assessing presence and type of UI to inform clinical management. Diagnosis of UI based on inaccurate methods may lead to unne... Read More about Evaluating methods of detecting and determining the type of urinary incontinence in adults after stroke: A systematic review.

Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy? (2023)
Journal Article
Ingleton, A., Raseta, M., Chung, R.-E., Kow, K. J. H., Weddell, J., Nayak, S., Jadun, C., Hashim, Z., Qayyum, N., Ferdinand, P., Natarajan, I., & Roffe, C. (2023). Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?. Stroke and Vascular Neurology, https://doi.org/10.1136/svn-2022-002267

Background: Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy (MT). Most patients undergoing MT are also given thrombolysis. Antiplatelet agents are contraindicated within 24 hours of thrombolysis... Read More about Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?.

Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials (2023)
Journal Article
Krishnan, K., Campos, P. B., Nguyen, T. N., Tan, C. W., Chan, S. L., Appleton, J. P., Law, Z., Hollingworth, M., Kirkman, M. A., England, T. J., Roffe, C., Macleod, M. J., Dawson, J., Bayraktutan, U., Werring, D. J., Sprigg, N., & Bath, P. M. (in press). Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials. Frontiers in Stroke, 2, 1256664. https://doi.org/10.3389/fstro.2023.1256664

Acute intracerebral hemorrhage is the most devastating stroke subtype and is associated with significant morbidity and mortality. Poor prognosis is associated with primary brain injury from the presenting hematoma, and despite advances in clinical tr... Read More about Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials.

The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study (2023)
Journal Article
Jakobek, W., Gravino, G., Nayak, S., Yang, Y., Ranjbar, J., & Roffe, C. (in press). The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study. Interventional Neuroradiology, https://doi.org/10.1177/15910199231201518

Endovascular mechanical thrombectomy for ischaemic stroke is one of the most effective treatments. Despite the devices and techniques that have been developed, thrombi are not always successfully retrieved. The incidence of futile reperfusion after s... Read More about The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study.

Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): effects on outcomes at day 365 in a randomised, sham-controlled, blinded, phase III, superiority ambulance-based trial. (2023)
Journal Article
Woodhouse, L. J., Appleton, J. P., Ankolekar, S., England, T. J., Mair, G., Muir, K., Price, C. I., Pocock, S., Randall, M., Robinson, T. G., Roffe, C., Sandset, E. C., Saver, J. L., Siriwardena, A. N., Sprigg, N., Wardlaw, J. M., & Bath, P. M. (in press). Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): effects on outcomes at day 365 in a randomised, sham-controlled, blinded, phase III, superiority ambulance-based trial. BMJ Open Neurology, 5(1), e000424. https://doi.org/10.1136/bmjno-2023-000424

The Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke Trial-2 (RIGHT-2) reported no overall treatment difference between glyceryl trinitrate (GTN) and sham at day 90. Here we assess participants' outcomes 1 year after randomisation.... Read More about Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): effects on outcomes at day 365 in a randomised, sham-controlled, blinded, phase III, superiority ambulance-based trial..

Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial. (2023)
Journal Article
Appleton, J. P., Woodhouse, L. J., Anderson, C. S., Ankolekar, S., Cala, L., Dixon, M., England, T. J., Krishnan, K., Mair, G., Muir, K. W., Potter, J., Price, C. I., Randall, M., Robinson, T. G., Roffe, C., Sandset, E. C., Saver, J. L., Shone, A., Siriwardena, A. N., Wardlaw, J. M., …Bath, P. M. (in press). Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial. Stroke and Vascular Neurology, svn-2022-001634. https://doi.org/10.1136/svn-2022-001634

The effect of transdermal glyceryl trinitrate (GTN, a nitrovasodilator) on clinical outcome when administered before hospital admission in suspected stroke patients is unclear. Here, we assess the safety and efficacy of GTN in the prespecified subgro... Read More about Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial..

Reperfusion by endovascular thrombectomy and early cerebral edema in anterior circulation stroke: Results from the SITS-International Stroke Thrombectomy Registry (2023)
Journal Article
Thorén, M., Escudero-Martínez, I., Andersson, T., Chen, S.-Y., Tsao, N., Khurana, D., Beretta, S., Peeters, A., Tsivgoulis, G., Roffe, C., & Ahmed, N. (2023). Reperfusion by endovascular thrombectomy and early cerebral edema in anterior circulation stroke: Results from the SITS-International Stroke Thrombectomy Registry. International Journal of Stroke, 18(10), 1193-1201. https://doi.org/10.1177/17474930231180451

Background:
A large infarct and expanding cerebral edema (CED) due to a middle cerebral artery occlusion confers a 70% mortality unless treated surgically. There is still conflicting evidence whether reperfusion is associated with a lower risk for C... Read More about Reperfusion by endovascular thrombectomy and early cerebral edema in anterior circulation stroke: Results from the SITS-International Stroke Thrombectomy Registry.

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease (2023)
Journal Article
Wardlaw, J. M., Woodhouse, L. J., Mhlanga, I. I., Oatey, K., Heye, A. K., Bamford, J., Cvoro, V., Doubal, F. N., England, T., Hassan, A., Montgomery, A., O’Brien, J. T., O'Brien, J. T., Roffe, C., Sprigg, N., Werring, D. J., Bath, P. M., Baigent, C., Ford, G., Emberson, J., …Elyas, S. (2023). Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease. JAMA Neurology, 80(7), 682. https://doi.org/10.1001/jamaneurol.2023.1526

ImportanceCerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), is the most common cause of vascular cognitive impairment, and impairs mobility and mood but has no specific treatment.ObjectiveTo test the feasibility, drug... Read More about Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease.

World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention (2023)
Journal Article
Roffe. (2023). World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention. Postępy w Kardiologii Interwencyjnej, 19(1), 6-13. https://doi.org/10.5114/aic.2023.124742

Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most cou... Read More about World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention.

Effects of blood pressure and tranexamic acid in spontaneous intracerebral haemorrhage: a secondary analysis of a large randomised controlled trial. (2023)
Journal Article
Appleton, J. P., Law, Z. K., Woodhouse, L. J., Al-Shahi Salman, R., Beridze, M., Christensen, H., Dineen, R. A., Guerrero, J. J. E., England, T. J., Karlinski, M., Krishnan, K., Laska, A. C., Lyrer, P., Ozturk, S., Roffe, C., Roberts, I., Robinson, T. G., Scutt, P., Werring, D. J., Bath, P. M., & Sprigg, N. (2023). Effects of blood pressure and tranexamic acid in spontaneous intracerebral haemorrhage: a secondary analysis of a large randomised controlled trial. BMJ Open Neurology, 5(1), Article e000423. https://doi.org/10.1136/bmjno-2023-000423

BackgroundTranexamic acid reduced haematoma expansion and early death, but did not improve functional outcome in the tranexamic acid for hyperacute spontaneous intracerebral haemorrhage-2 (TICH-2) trial. In a predefined subgroup, there was a statisti... Read More about Effects of blood pressure and tranexamic acid in spontaneous intracerebral haemorrhage: a secondary analysis of a large randomised controlled trial..

Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial (2022)
Journal Article
Roffe. (2022). Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine, https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial.

Systematic voiding programme in adults with urinary incontinence following acute stroke: the ICONS-II RCT (2022)
Journal Article
Watkins, C., Tishkovskaya, S., Brown, C., Sutton, C., Garcia, Y. S., Forshaw, D., Prescott, G., Thomas, L., Roffe, C., Booth, J., Bennett, K., Roe, B., Hollingsworth, B., Mateus, C., Britt, D., & Panton, C. (2022). Systematic voiding programme in adults with urinary incontinence following acute stroke: the ICONS-II RCT. Health Technology Assessment, 26(31), 1-88. https://doi.org/10.3310/eftv1270

Background Urinary incontinence affects around half of stroke survivors in the acute phase, and it often presents as a new problem after stroke or, if pre-existing, worsens significantly, adding to the disability and helplessness caused by neurologic... Read More about Systematic voiding programme in adults with urinary incontinence following acute stroke: the ICONS-II RCT.