Skip to main content

Research Repository

Advanced Search

All Outputs (184)

Does metformin protect against osteoarthritis? An electronic health record cohort study (2017)
Journal Article
Barnett, L. A., Jordan, K. P., Edwards, J. J., & Van Der Windt, D. A. (2017). Does metformin protect against osteoarthritis? An electronic health record cohort study. Primary Health Care Research and Development, 623-628. https://doi.org/10.1017/s1463423617000287

Background Obesity is a major risk factor for osteoarthritis (OA) whilst there is some evidence that diabetes also increases risk. Metformin is a common oral treatment for those with diabetes. Objective The aim is to investigate whether metformi... Read More about Does metformin protect against osteoarthritis? An electronic health record cohort study.

Seeing the light at the end of the carpal tunnel: the challenges of recruiting sites to a clinical trial of an investigational medicinal product in primary care (2017)
Presentation / Conference
Myers, H., Burton, C., Robinson, M., Davenport, G., Dziedzic, K., van der Windt, D., …Hay, E. (2017, May). Seeing the light at the end of the carpal tunnel: the challenges of recruiting sites to a clinical trial of an investigational medicinal product in primary care. Poster presented at 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials, Liverpool, UK

The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581). (2017)
Journal Article
Foster, N. E., Konstantinou, K., Lewis, M., Ogollah, R., Dunn, K. M., van der Windt, D., …Hay, E. M. (2017). The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581). BMC Musculoskeletal Disorders, 18, Article 172. https://doi.org/10.1186/s12891-017-1513-5

BACKGROUND: Sciatica has a substantial impact on patients, and is associated with high healthcare and societal costs. Although there is variation in the clinical management of sciatica, the current model of care usually involves an initial period of... Read More about The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581)..

Protocol: a systematic review of studies developing and/or evaluating search strategies to identify prognosis studies (2017)
Journal Article
Corp, N., Jordan, J. L., Hayden, J. A., Irvin, E., Parker, R., Smith, A., & van der Windt, D. A. (2017). Protocol: a systematic review of studies developing and/or evaluating search strategies to identify prognosis studies. Systematic Reviews, 6, Article 88. https://doi.org/10.1186/s13643-017-0482-y

BACKGROUND Prognosis research is on the rise, its importance recognised because chronic health conditions and diseases are increasingly common and costly. Prognosis systematic reviews are needed to collate and synthesise these research findings, esp... Read More about Protocol: a systematic review of studies developing and/or evaluating search strategies to identify prognosis studies.

Brief pain re-assessment provided more accurate prognosis than baseline information for low-back or shoulder pain (2017)
Journal Article
Jordan, Dunn, & Van Der Windt. (2017). Brief pain re-assessment provided more accurate prognosis than baseline information for low-back or shoulder pain. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-017-1502-8

Background Research investigating prognosis in musculoskeletal pain conditions has only been moderately successful in predicting which patients are unlikely to recover. Clinical decision making could potentially be improved by combining information... Read More about Brief pain re-assessment provided more accurate prognosis than baseline information for low-back or shoulder pain.

Prognosis of undiagnosed chest pain: linked electronic health record cohort study (2017)
Journal Article
Jordan, K. P., Timmis, A., Croft, P., van der Windt, D. A., Denaxas, S., González-Izquierdo, A., …Hemingway, H. (2017). Prognosis of undiagnosed chest pain: linked electronic health record cohort study. BMJ, 357, Article j1194. https://doi.org/10.1136/bmj.j1194

Objective To ascertain long term cardiovascular outcomes in patients whose chest pain remained undiagnosed six months after first presentation.Design Cohort study.Setting UK electronic health record database (CALIBER) linking primary care, secondary... Read More about Prognosis of undiagnosed chest pain: linked electronic health record cohort study.

Can we identify who gets benefit or harm from mycophenolate mofetil in systemic lupus erythematosus? a systematic review (2017)
Journal Article
Van Der Windt. (2017). Can we identify who gets benefit or harm from mycophenolate mofetil in systemic lupus erythematosus? a systematic review. Seminars in Arthritis and Rheumatism, 65-78. https://doi.org/10.1016/j.semarthrit.2017.01.009

AbstractObjectives We aimed to summarize the evidence examining factors that predict differential response to mycophenolate mofetil (MMF) in systemic lupus erythematosus (SLE). Methods Systematic searches of randomized clinical trials (RCT) to identi... Read More about Can we identify who gets benefit or harm from mycophenolate mofetil in systemic lupus erythematosus? a systematic review.

Rating of Included Trials on the Efficacy-Effectiveness Spectrum (RITES): development of a new tool for systematic reviews (2017)
Journal Article
Van Der Windt, D. (2017). Rating of Included Trials on the Efficacy-Effectiveness Spectrum (RITES): development of a new tool for systematic reviews. Journal of Clinical Epidemiology, 95-104. https://doi.org/10.1016/j.jclinepi.2017.01.010

AbstractBackground Randomized trials may be designed to provide evidence more strongly related to efficacy or effectiveness of an intervention. When systematic reviews are used to inform clinical or policy decisions, it is important to know the effic... Read More about Rating of Included Trials on the Efficacy-Effectiveness Spectrum (RITES): development of a new tool for systematic reviews.

Generic prognostic factors for musculoskeletal pain in primary care: a systematic review. (2017)
Journal Article
Artus, M., Campbell, P., Mallen, C., Dunn, K., & van der Windt, D. (2017). Generic prognostic factors for musculoskeletal pain in primary care: a systematic review. BMJ Open, e012901 - ?. https://doi.org/10.1136/bmjopen-2016-012901

OBJECTIVES: To summarise the evidence for generic prognostic factors across a range of musculoskeletal (MSK) conditions. SETTING: primary care. METHODS AND OUTCOMES: Comprehensive systematic literature review. MEDLINE, CINAHL, PsychINFO and EMBASE we... Read More about Generic prognostic factors for musculoskeletal pain in primary care: a systematic review..

Characteristics of patients with low back and leg pain seeking treatment in primary care: baseline results from the ATLAS cohort study. (2016)
Journal Article
Konstantinou, K., Dunn, K., Ogollah, R., Vogel, S., & Hay, E. (2016). Characteristics of patients with low back and leg pain seeking treatment in primary care: baseline results from the ATLAS cohort study. BMC Musculoskeletal Disorders, 332. https://doi.org/10.1186/s12891-015-0787-8

Background Patients with back pain radiating to the leg(s) report worse symptoms and poorer recovery than those with back pain alone. Robust evidence regarding their epidemiological profile is lacking from primary care, the setting where most of the... Read More about Characteristics of patients with low back and leg pain seeking treatment in primary care: baseline results from the ATLAS cohort study..

The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome (2016)
Journal Article
Chesterton, L. S., Dziedzic, K. S., Van Der Windt, D. A., Davenport, G., Myers, H. L., Rathod, T., …Hay, E. M. (2016). The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome. BMC Musculoskeletal Disorders, 415 - ?. https://doi.org/10.1186/s12891-016-1264-8

BACKGROUND: Patients diagnosed with idiopathic mild to moderate carpal tunnel syndrome (CTS) are usually managed in primary care and commonly treated with night splints and/or corticosteroid injection. The comparative effectiveness of these intervent... Read More about The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome.

Applying causal mediation methods to clinical trial data: What can we learn about why our interventions (don't) work? (2016)
Journal Article
Van Der Windt. (2016). Applying causal mediation methods to clinical trial data: What can we learn about why our interventions (don't) work?. European Journal of Pain, 614-622. https://doi.org/10.1002/ejp.964

BACKGROUND: Many randomized controlled trials (RCTs) of psychosocial interventions for low back pain (LBP) have been found to have only small effects on disability outcomes. Investigations of the specific mechanisms that may lead to an improvement in... Read More about Applying causal mediation methods to clinical trial data: What can we learn about why our interventions (don't) work?.

Does a modified STarT Back Tool predict outcome with a broader group of musculoskeletal patients than back pain? A secondary analysis of cohort data. (2016)
Journal Article
Hill, J., Afolabi, E. K., Lewis, M., Dunn, K., Roddy, E., Van Der Windt, D., & Foster, N. E. (2016). Does a modified STarT Back Tool predict outcome with a broader group of musculoskeletal patients than back pain? A secondary analysis of cohort data. BMJ Open, e012445 - ?. https://doi.org/10.1136/bmjopen-2016-012445

OBJECTIVES: The STarT Back Tool has good predictive performance for non-specific low back pain in primary care. We therefore aimed to investigate whether a modified STarT Back Tool predicted outcome with a broader group of musculoskeletal patients, a... Read More about Does a modified STarT Back Tool predict outcome with a broader group of musculoskeletal patients than back pain? A secondary analysis of cohort data..

Keele Aches and Pains Study protocol: validity, acceptability, and feasibility of the Keele STarT MSK tool for subgrouping musculoskeletal patients in primary care. (2016)
Journal Article
Campbell, P., Hill, J., Protheroe, J., Afolabi, E., Lewis, M., Beardmore, R., …Dunn, K. (2016). Keele Aches and Pains Study protocol: validity, acceptability, and feasibility of the Keele STarT MSK tool for subgrouping musculoskeletal patients in primary care. Journal of Pain Research, 2016(9), 807 -818. https://doi.org/10.2147/JPR.S116614

Musculoskeletal conditions represent a considerable burden worldwide, and are predominantly managed in primary care. Evidence suggests that many musculoskeletal conditions share similar prognostic factors. Systematically assessing patient’s prognosis... Read More about Keele Aches and Pains Study protocol: validity, acceptability, and feasibility of the Keele STarT MSK tool for subgrouping musculoskeletal patients in primary care..

Exploring what factors mediate treatment effect: Example of the STarT Back study high-risk intervention (2016)
Journal Article
Mansell, G., Hill, J., Main, C., Vowles, K. E., & Van Der Windt, D. (2016). Exploring what factors mediate treatment effect: Example of the STarT Back study high-risk intervention. Journal of Pain, 17(11), 1237-1245. https://doi.org/10.1016/j.jpain.2016.08.005

Interventions developed to improve disability outcomes for low back pain (LBP) often show only small effects. Mediation analysis was used to investigate what led to the effectiveness of the STarT Back trial, a large primary care-based trial that trea... Read More about Exploring what factors mediate treatment effect: Example of the STarT Back study high-risk intervention.

Exploring What Factors Mediate Treatment Effect: Example of the STarT Back Study High-Risk Intervention. (2016)
Journal Article
Mansell, G., Hill, J. C., Main, C., Vowles, K. E., & van der Windt, D. (2016). Exploring What Factors Mediate Treatment Effect: Example of the STarT Back Study High-Risk Intervention. Journal of Pain, 17(11), 1237-1245. https://doi.org/10.1016/j.jpain.2016.08.005

Interventions developed to improve disability outcomes for low back pain (LBP) often show only small effects. Mediation analysis was used to investigate what led to the effectiveness of the STarT Back trial, a large primary care-based trial that trea... Read More about Exploring What Factors Mediate Treatment Effect: Example of the STarT Back Study High-Risk Intervention..

Exploring What Factors Mediate Treatment Effect: Example of the STarT Back Study High-Risk Intervention. (2016)
Journal Article
Mansell, G., Hill, J. C., Main, C., Vowles, K. E., & van der Windt, D. (2016). Exploring What Factors Mediate Treatment Effect: Example of the STarT Back Study High-Risk Intervention. Journal of Pain, 17(11), 1237-1245. https://doi.org/10.1016/j.jpain.2016.08.005

Interventions developed to improve disability outcomes for low back pain (LBP) often show only small effects. Mediation analysis was used to investigate what led to the effectiveness of the STarT Back trial, a large primary care-based trial that trea... Read More about Exploring What Factors Mediate Treatment Effect: Example of the STarT Back Study High-Risk Intervention..