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Does metformin protect against osteoarthritis? An electronic health record cohort study

Barnett, Lauren A. ; Jordan, Kelvin P.; Edwards, John J.; Van Der Windt, Danielle A.

Does metformin protect against osteoarthritis? An electronic health record cohort study Thumbnail


Authors

Lauren A. Barnett

John J. Edwards



Abstract

Background
Obesity is a major risk factor for osteoarthritis (OA) whilst there is some evidence that diabetes also increases risk. Metformin is a common oral treatment for those with diabetes.

Objective
The aim is to investigate whether metformin reduces the risk of OA.

Methods
This was a cohort study set within the Consultations in Primary Care Archive, with 3217 patients with type 2 diabetes. Patients at 13 general practices with recorded type 2 diabetes in the baseline period (2002–2003) and no prior record of OA were identified. Exposure was a prescription for metformin. Outcome was an OA record during follow up. Cox proportional hazard models with Gamma frailty term were fitted: adjusted for age, gender, deprivation, and comorbidity.

Results
There was no association between prescribed metformin treatment at baseline and OA (adjusted HR: 1.02, 95% CI: 0.91, 1.15). A similar non- significant association was found when allowing exposure status of prescription of metformin to vary over time.

Citation

Barnett, L. A., Jordan, K. P., Edwards, J. J., & Van Der Windt, D. A. (2017). Does metformin protect against osteoarthritis? An electronic health record cohort study. Primary Health Care Research and Development, 623-628. https://doi.org/10.1017/s1463423617000287

Journal Article Type Article
Acceptance Date Apr 16, 2017
Publication Date May 25, 2017
Journal Primary Health Care Research and Development
Print ISSN 1463-4236
Publisher Cambridge University Press
Pages 623-628
DOI https://doi.org/10.1017/s1463423617000287
Keywords cohort, osteoarthritis, survival analysis
Publisher URL http://doi.org/10.1017/S1463423617000287
PMID 28539134

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