Lauren A. Barnett
Does metformin protect against osteoarthritis? An electronic health record cohort study
Barnett, Lauren A. ; Jordan, Kelvin P.; Edwards, John J.; Van Der Windt, Danielle A.
Authors
Kelvin Jordan k.p.jordan@keele.ac.uk
John J. Edwards
Danielle Van Der Windt d.van.der.windt@keele.ac.uk
Abstract
Background
Obesity is a major risk factor for osteoarthritis (OA) whilst there is some evidence that diabetes also increases risk. Metformin is a common oral treatment for those with diabetes.
Objective
The aim is to investigate whether metformin reduces the risk of OA.
Methods
This was a cohort study set within the Consultations in Primary Care Archive, with 3217 patients with type 2 diabetes. Patients at 13 general practices with recorded type 2 diabetes in the baseline period (2002–2003) and no prior record of OA were identified. Exposure was a prescription for metformin. Outcome was an OA record during follow up. Cox proportional hazard models with Gamma frailty term were fitted: adjusted for age, gender, deprivation, and comorbidity.
Results
There was no association between prescribed metformin treatment at baseline and OA (adjusted HR: 1.02, 95% CI: 0.91, 1.15). A similar non- significant association was found when allowing exposure status of prescription of metformin to vary over time.
Citation
Barnett, L. A., Jordan, K. P., Edwards, J. J., & Van Der Windt, D. A. (2017). Does metformin protect against osteoarthritis? An electronic health record cohort study. Primary Health Care Research and Development, 623-628. https://doi.org/10.1017/s1463423617000287
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 16, 2017 |
Publication Date | May 25, 2017 |
Journal | Primary Health Care Research and Development |
Print ISSN | 1463-4236 |
Publisher | Cambridge University Press |
Pages | 623-628 |
DOI | https://doi.org/10.1017/s1463423617000287 |
Keywords | cohort, osteoarthritis, survival analysis |
Publisher URL | http://doi.org/10.1017/S1463423617000287 |
PMID | 28539134 |
Files
K Jordan - Does metformin protect against osteoarthritis.pdf
(527 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
K Jordan - Author Page.pdf
(244 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
You might also like
Where does it hurt? Small area estimates and inequality in the prevalence of chronic pain
(2023)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search