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All Outputs (29)

P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review (2024)
Presentation / Conference
Dahanayake, C., Bajpai, R., Jordan, K. M., Lambie, M., & Roddy, E. (2024, April). P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Uric acid nephrolithiasis is a recognised side-effect of uricosuric therapies and a contraindication to their use. The objective of this systematic review was to assess the incidence and risk of nephrolithiasis in people with gout re... Read More about P082 Nephrolithiasis associated with uricosuric therapies for the treatment of gout: a systematic review.

P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform (2024)
Presentation / Conference
Russell, M. D., Massey, J., Roddy, E., MacKenna, B., Bacon, S., Goldacre, B., …Galloway, J. (2024, April). P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Gout is the most common inflammatory arthritis worldwide, yet one of the worst managed. Few population-level studies have evaluated how the COVID-19 pandemic impacted on incidence, prevalence, management and hospitalisations for peopl... Read More about P086 Trends in the Incidence and Management of Gout in England: A Nationwide Study using the OpenSAFELY Platform.

P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study (2024)
Presentation / Conference
Russell, M. D., Ameyaw-Kyeremeh, L., Dell'Accio, F., Lapham, H., Head, N., Stovin, C., …Galloway, J. B. (2024, April). P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Hospitalisations for gout flares have doubled in England during the last 15 years. Despite this, no studies have evaluated strategies designed to increase the uptake of urate-lowering therapy (ULT) in people hospitalised for gout flar... Read More about P085 Implementing treat-to-target urate-lowering therapy during hospitalisations for gout flares: a prospective cohort study.

POS0508 A RANDOMISED CONTROLLED TRIAL COMPARING ANAKINRA VERSUS STEROIDS FOR THE TREATMENT OF GOUT ATTACKS IN PEOPLE WITH RENAL DISEASE (ASGARD): A FEASIBILITY STUDY (2023)
Presentation / Conference
Balasubramaniam, G., Almond, M., Harnett, P., Zhang, J., Turner, D., Scales, J., …Dasgupta, B. (2023, May). POS0508 A RANDOMISED CONTROLLED TRIAL COMPARING ANAKINRA VERSUS STEROIDS FOR THE TREATMENT OF GOUT ATTACKS IN PEOPLE WITH RENAL DISEASE (ASGARD): A FEASIBILITY STUDY. Paper presented at EULAR 2023 European Congress of Rheumatology, Milan, Italy

P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study (2023)
Presentation / Conference
Padmanabhan, N., Muller, S., Bailey, J., Helliwell, T., Mackie, S. L., Mallen, C. D., & Roddy, E. (2023, April). P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Giant cell arteritis (GCA) is considered a medical emergency, and relapses are common, affecting around 50% of patients. Many of the early symptoms of GCA are non-specific and highly prevalent in older people, making the diagnosis challenging. The... Read More about P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study.

P102 Barriers and facilitators to lifestyle change in people living with gout: a scoping review of qualitative studies (2023)
Presentation / Conference
Watson, L., Cornwall, N., Jinks, C., Bradbury, K., Goff, L., Little, P., …Roddy, E. (2023, April). P102 Barriers and facilitators to lifestyle change in people living with gout: a scoping review of qualitative studies. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Background/Aims Lifestyle, especially diet and alcohol, has been implicated in the causation of gout for centuries and the dietary factors which may trigger flares remain of great interest to people living with gout and their families. However, ther... Read More about P102 Barriers and facilitators to lifestyle change in people living with gout: a scoping review of qualitative studies.

what factors require consideration when individualising exercise interventions for people with osteoarthritis? Consensus of experts using a delphi methodology (2023)
Presentation / Conference
Yaseen, K., Zhang, W., Doherty, M., Abhishek, A., Jamtvedt, G., Martinez, M., …Hall, M. (2023, March). what factors require consideration when individualising exercise interventions for people with osteoarthritis? Consensus of experts using a delphi methodology. Poster presented at 2023 OARSI World Congress on Osteoarthritis, Sheraton Denver Downtown Hotel, Denver, USA

A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout (2022)
Presentation / Conference
Merriman, T., Matsuo, H., Takei, R., Leask, M., Topless, R., Shirai, Y., …Major, T. (2022, November). A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout. Presented at ACR Convergence 2022

Background/Purpose: Genome-wide association studies (GWAS) in gout have been relatively small (≤13,179 people with gout) and have provided little insight into the progression from hyperuricemia to gout. We present a gout GWAS that includes 120,282 pe... Read More about A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout.

Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study (2022)
Presentation / Conference
Rathod-Mistry, T., Roddy, E., Jordan, K., Mallen, C., & Blagojevic-Bucknall, M. (2022, August). Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study

Background: Allopurinol is intended to be taken for life in the treatment of gout. In UK primary care, treatment is suboptimal with up to 30% of indicated patients being treated within five years of diagnosis and once prescribed allopurinol, treatmen... Read More about Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study.

NEUROPATHIC PAIN IN FIRST METATARSOPHALANGEAL JOINT OSTEOARTHRITIS: FREQUENCY AND ASSOCIATED FACTORS (2022)
Presentation / Conference
Roddy. (2022, May). NEUROPATHIC PAIN IN FIRST METATARSOPHALANGEAL JOINT OSTEOARTHRITIS: FREQUENCY AND ASSOCIATED FACTORS. Presented at Australian Rheumatology Association 62nd Annual Scientific Meeting, Sydney, Adelaide, Brisbane, Hobart, Melbourne, Australia and Auckland, New Zealand

Aim: To determine whether neuropathic pain is a feature of first metatarsophalangeal (MTP) joint osteoarthritis (OA). Method: Ninety-eight participants (54 women and 44 men, mean age 57.4?years, standard deviation 10.3) with symptomatic radiographic... Read More about NEUROPATHIC PAIN IN FIRST METATARSOPHALANGEAL JOINT OSTEOARTHRITIS: FREQUENCY AND ASSOCIATED FACTORS.

O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT) (2020)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020, April). O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT). Presented at British Society for Rheumatology Annual Conference 2020, Glasgow, Scotland, UK

Background Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared the clinical and cost-effectiveness of an ultrasound-guided intra-articular hip injection (USGI) of 4... Read More about O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT).

Association of a Gout Polygenic Risk Score with Disease Severity Phenotypes Amongst Caucasian Gout Patients in Three Independent Cohorts (2019)
Presentation / Conference
Sumpter, N., Merriman, T., Reynolds, R., Abhishek, A., Andres, M., Dalbeth, N., …Uhlig, T. (2019, November). Association of a Gout Polygenic Risk Score with Disease Severity Phenotypes Amongst Caucasian Gout Patients in Three Independent Cohorts. Paper presented at 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA

Background/Purpose: This study aimed to determine whether a polygenic risk score (PRS) based on gout-associated genetic variants is associated with gout disease severity phenotypes such as age at onset, presence of tophi and flare frequency. Me... Read More about Association of a Gout Polygenic Risk Score with Disease Severity Phenotypes Amongst Caucasian Gout Patients in Three Independent Cohorts.

Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT) (2019)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2019, November). Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT). Paper presented at 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA

Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of an ultrasound-guided intra-articular hip inject... Read More about Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT).

Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study (2018)
Presentation / Conference
Crowley, L., Abdul Sultan, A., Roddy, E., Mallen, C., Protheroe, J., & Clarson, L. (2018, October). Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study. Poster presented at 2018 ACR/ARHP Annual Meeting

Background/Purpose: Evidence is conflicting concerning dementia risk in gout patients, with hyperuricaemia proposed to exert a neuroprotective effect. Serum urate (sUA) targets guiding urate-lowering therapies (ULT) are poorly evidenced-based and th... Read More about Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study.

Efficacy of Shoe-Stiffening Inserts for First Metatarsophalangeal Joint Osteoarthritis: Preliminary Findings from the Simple Randomised Controlled Trial (2018)
Presentation / Conference
Munteanu, S., Landorf, K., McClelland, J., Roddy, E., Cicuttini, F., Shiell, A., …Menz, H. B. (2018, October). Efficacy of Shoe-Stiffening Inserts for First Metatarsophalangeal Joint Osteoarthritis: Preliminary Findings from the Simple Randomised Controlled Trial

Background/Purpose: This trial assessed the efficacy of shoe-stiffening inserts for reducing pain associated with first metatarsophalangeal joint (MTPJ) osteoarthritis (OA). Methods: One hundred participants (45 men 55 women, mean age 57.5, SD 10.... Read More about Efficacy of Shoe-Stiffening Inserts for First Metatarsophalangeal Joint Osteoarthritis: Preliminary Findings from the Simple Randomised Controlled Trial.