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All Outputs (107)

Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain (2018)
Journal Article
Healey, E. L., Afolabi, E. K., Lewis, M., Edwards, J. J., Jordan, K. P., Finney, A., …Dziedzic, K. S. (2018). Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain. BMC Musculoskeletal Disorders, 19, Article 295. https://doi.org/10.1186/s12891-018-2196-2

Background Osteoarthritis (OA) is a leading cause of pain and disability. NICE OA guidelines (2008) recommend that patients with OA should be offered core treatments in primary care. Assessments of OA management have identified a need to improve pri... Read More about Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain.

Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC) (2018)
Journal Article
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., …Wilkinson, C. (2018). Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC). Trials, 19, Article 408. https://doi.org/10.1186/s13063-018-2801-6

BACKGROUND: Adalimumab, a biological treatment targeting tumour necrosis factor a, might be useful in sciatica. This paper describes the challenges faced when developing a new treatment pathway for a randomised controlled trial of adalimumab for peop... Read More about Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).

A multi-modal recruitment strategy using social media and internet-mediated methods to recruit a multidisciplinary, international sample of clinicians to an online research study. (2018)
Journal Article
McRobert, C. J., Hill, J., Smale, T., Hay, E., & Van Der Windt, D. (2018). A multi-modal recruitment strategy using social media and internet-mediated methods to recruit a multidisciplinary, international sample of clinicians to an online research study. PloS one, 13(7), Article e0200184. https://doi.org/10.1371/journal.pone.0200184

BACKGROUND: Challenges exist in recruiting an international sample of clinicians and researchers to an online survey. Traditional recruitment methods remain relevant but issues such as narrow geographical reach, high cost and time intensity limit wha... Read More about A multi-modal recruitment strategy using social media and internet-mediated methods to recruit a multidisciplinary, international sample of clinicians to an online research study..

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials (2018)
Report
Hay, E., Dziedzic, K., Foster, N., Peat, G., van der Windt, D., Bartlam, B., …Croft, P. (2018). Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. NIHR. PGfAR as project number RP-PG-0407-10386. Secretary of State for Health and Social Care

Background Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based interventions can reduce OA pain and disability. Objectives Th... Read More about Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial. (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholls, E., Tooth, S., Hay, E., Foster, N. E., & Holden, M. (2018). Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial. Rheumatology Advances in Practice, rky018 - ?. https://doi.org/10.1093/rap/rky018

Objectives: Evidence regarding the cost-effectiveness of enhancing physical therapy exercise programmes in order to improve outcomes for patients with knee OA remains unclear. This study investigates the cost-effectiveness of two enhanced physical th... Read More about Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial..

Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain (2018)
Journal Article
Stynes, S., Konstantinou, K., Ogollah, R., Hay, E., & Dunn, K. (2018). Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain. PloS one, 1 -14. https://doi.org/10.1371/journal.pone.0191852

Background Identification of sciatica may assist timely management but can be challenging in clinical practice. Diagnostic models to identify sciatica have mainly been developed in secondary care settings with conflicting reference standard selection... Read More about Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain.

Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., …Mallen, C. D. (2018). Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial. Arthritis Care and Research, 70(12), 1787-1794. https://doi.org/10.1002/acr.23568

OBJECTIVE: To investigate the cost-effectiveness (cost-utility) of introducing general practitioner screening for anxiety and depression in patients consulting with osteoarthritis (OA). METHODS: A cluster-randomised trial-based economic evaluation to... Read More about Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial.

Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis (2018)
Journal Article
Oppong, R., Jowett, S., Lewis, M., Clarkson, K., Paskins, Z., Croft, P., …Dziedzic, K. (2018). Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis. Rheumatology, 57(6), 1056-1063. https://doi.org/10.1093/rheumatology/key037

Objectives: The aim of this study was to estimate the cost-effectiveness of a model OA consultation for OA to support self-management compared with usual care. Methods: An incremental cost-utility analysis using patient responses to the three-level E... Read More about Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis.

Using an internet intervention to support self-management of low back pain in primary care: findings from a randomised controlled feasibility trial (SupportBack). (2018)
Journal Article
Geraghty, A. W. A., Stanford, R., Stuart, B., Little, P., Roberts, L. C., Foster, N. E., …Yardley, L. (2018). Using an internet intervention to support self-management of low back pain in primary care: findings from a randomised controlled feasibility trial (SupportBack). BMJ Open, 8(3), Article e016768. https://doi.org/10.1136/bmjopen-2017-016768

OBJECTIVE: To determine the feasibility of a randomised controlled trial of an internet intervention for low back pain (LBP) using three arms: (1) usual care, (2) usual care plus an internet intervention or (3) usual care plus an internet interventio... Read More about Using an internet intervention to support self-management of low back pain in primary care: findings from a randomised controlled feasibility trial (SupportBack)..

Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials. (2018)
Journal Article
Green, D., Lewis, M., Mansell, G., Artus, M., Dziedzic, K., Hay, E., …Van Der Windt, D. (2018). Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials. European Journal of Pain, 22(6), 1057-1070. https://doi.org/10.1002/ejp.1190

BACKGROUND: Previous research has identified similar prognostic factors in patients with musculoskeletal (MSK) conditions regardless of pain presentation, generating opportunities for management based on prognosis rather than specific pain presentati... Read More about Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials..

Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up. (2018)
Journal Article
Stynes, S., Konstantinou, K., Ogollah, R., Hay, E. M., & Dunn, K. M. (2018). Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up. PAIN, 159(4), https://doi.org/10.1097/j.pain.0000000000001147

Traditionally, low back-related leg pain (LBLP) is diagnosed clinically as referred leg pain or sciatica (nerve root involvement). However, within the spectrum of LBLP, we hypothesised that there may be other unrecognised patient subgroups. This stud... Read More about Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up..

Effectiveness and costs of a vocational advice service to improve work outcomes in patients with musculoskeletal pain in primary care: a cluster randomised trial (SWAP trial ISRCTN 52269669). (2018)
Journal Article
Wynne-Jones, G., Artus, M., Bishop, A., Lawton, S., Lewis, M., Jowett, S., …Van Der Windt, D. (2018). Effectiveness and costs of a vocational advice service to improve work outcomes in patients with musculoskeletal pain in primary care: a cluster randomised trial (SWAP trial ISRCTN 52269669). PAIN, 159(1), 128-138. https://doi.org/10.1097/j.pain.0000000000001075

Musculoskeletal pain is a common cause of work absence and early intervention is advocated to prevent the adverse health and economic consequences of longer-term absence. This cluster randomised controlled trial investigated the effect of introducing... Read More about Effectiveness and costs of a vocational advice service to improve work outcomes in patients with musculoskeletal pain in primary care: a cluster randomised trial (SWAP trial ISRCTN 52269669)..

The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol (2017)
Journal Article
Healey, E., Jinks, C., Foster, N., Chew-Graham, Chew-Graham, C., Pincus, T., …McBeth, J. (2017). The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol. Musculoskeletal Care, 16(1), https://doi.org/10.1002/msc.1222

INTRODUCTION: This pilot trial will inform the design and methods of a future full-scale randomized controlled trial (RCT) and examine the feasibility, acceptability and fidelity of the Increasing Physical activity in Older People with chronic Pain (... Read More about The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol.

Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort (2017)
Journal Article
Konstantinou, K., Dunn, K., Ogollah, R., Lewis, M., Van Der Windt, D., Hay, E., & Study Team, A. (2017). Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort. Spine Journal, 1030-1040. https://doi.org/10.1016/j.spinee.2017.10.071

Background Context Evidence is lacking on the prognosis and prognostic factors of back-related leg pain and sciatica in patients seeing their primary care physicians. This evidence could guide timely appropriate treatment and referral decisions.... Read More about Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort.

Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (2017)
Journal Article
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., …Wilkinson, C. Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica. Health Technology Assessment, 21(60), 1-180. https://doi.org/10.3310/hta21600

Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial (2017)
Journal Article
Dziedzic, K., Hay, E., Porcheret, M., Afolabi, E., Lewis, A., Morden, A., …Healey, E. (2018). Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial. Osteoarthritis and Cartilage, 26(1), 43-53. https://doi.org/10.1016/j.joca.2017.09.010

Objective To determine the effectiveness of a model osteoarthritis consultation, compared with usual care, on physical function and uptake of National Institute for Health and Care Excellence (NICE) osteoarthritis recommendations, in adults =45 year... Read More about Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial.

Effect of a model consultation informed by guideline on recorded quality of care of osteoarthritis (MOSAICS): a cluster randomised controlled trial in primary care (2017)
Journal Article
Jordan, K., Edwards, J., Porcheret, M., Healey, E., Jinks, C., Bedson, J., …Dziedzic, K. (2017). Effect of a model consultation informed by guideline on recorded quality of care of osteoarthritis (MOSAICS): a cluster randomised controlled trial in primary care. Osteoarthritis and Cartilage, 25(10), 1588-1597. https://doi.org/10.1016/j.joca.2017.05.017

Objective To determine the effect of a model osteoarthritis (OA) consultation (MOAC) informed by National Institute for Health and Care Excellence (NICE) recommendations compared with usual care on recorded quality of care of clinical OA in general... Read More about Effect of a model consultation informed by guideline on recorded quality of care of osteoarthritis (MOSAICS): a cluster randomised controlled trial in primary care.

Seeing the light at the end of the carpal tunnel: the challenges of recruiting sites to a clinical trial of an investigational medicinal product in primary care (2017)
Presentation / Conference
Myers, H., Burton, C., Robinson, M., Davenport, G., Dziedzic, K., van der Windt, D., …Hay, E. (2017, May). Seeing the light at the end of the carpal tunnel: the challenges of recruiting sites to a clinical trial of an investigational medicinal product in primary care. Poster presented at 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials, Liverpool, UK

The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581). (2017)
Journal Article
Foster, N. E., Konstantinou, K., Lewis, M., Ogollah, R., Dunn, K. M., van der Windt, D., …Hay, E. M. (2017). The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581). BMC Musculoskeletal Disorders, 18, Article 172. https://doi.org/10.1186/s12891-017-1513-5

BACKGROUND: Sciatica has a substantial impact on patients, and is associated with high healthcare and societal costs. Although there is variation in the clinical management of sciatica, the current model of care usually involves an initial period of... Read More about The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581)..