Skip to main content

Research Repository

Advanced Search

All Outputs (100)

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11(1), Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background: Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

P084 Implementing an osteoporosis shared decision-making intervention in Fracture Liaison Services: interview findings from the iFraP process evaluation (2025)
Presentation / Conference Contribution
Bullock, L., Cherrington, A., Clark, E. M., Fleming, J., Bentley, I., Nicholls, E., Webb, D., Smith, J., Lewis, S., Horne, R., O’Neill, T. W., Mallen, C. D., Jinks, C., & Paskins, Z. (2025, April). P084 Implementing an osteoporosis shared decision-making intervention in Fracture Liaison Services: interview findings from the iFraP process evaluation. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to reach decisions about care. The improving uptake of Fracture Prevention drug treatments (iFraP)... Read More about P084 Implementing an osteoporosis shared decision-making intervention in Fracture Liaison Services: interview findings from the iFraP process evaluation.

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol (2024)
Journal Article
Bullock, L., Nicholls, E., Cherrington, A., Butler-Walley, S., Clark, E. M., Fleming, J., Leyland, S., Bentley, I., Thomas, S., Iglesias-Urrutia, C. P., Webb, D., Smith, J., Bathers, S., Lewis, S., Clifford, A., Siciliano, M., Protheroe, J., Ryan, S., Lefroy, J., Dale, N., …Paskins, Z. (2024). A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. NIHR Open Research, https://doi.org/10.3310/nihropenres.13571.2

Background
Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and val... Read More about A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol.

Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study. (2024)
Preprint / Working Paper
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C. D., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2024). Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study

Background:

Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence–based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore... Read More about Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study..

Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study (2024)
Journal Article
Bullock, L., Cherrington, A., Clark, E. M., Fleming, J., Bentley, I., Nicholls, E., Webb, D., Smith, J., Bathers, S., Lewis, S., Horne, R., O'Neill, T. W., Mallen, C. D., Jinks, C., & Paskins, Z. (in press). Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study. NIHR Open Research, 4, 70. https://doi.org/10.3310/nihropenres.13751.1

Background
High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and v... Read More about Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study.

Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials (2024)
Journal Article
Holden, M. A., Murphy, M., Simkins, J., Thomas, M. J., Huckfield, L., Quicke, J. G., Halliday, N., Birrell, F. N., Borrelli, B., Callaghan, M. J., Dziedzic, K., Felson, D., Foster, N. E., Ingram, C., Jinks, C., Jowett, S., Nicholls, E., & Peat, G. (2024). Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.08.010

Objective
To identify and synthesise the content of knee bracing interventions in randomised controlled trials (RCTs) of knee osteoarthritis (OA).

Design
In this scoping review, three electronic databases (PubMed, Web of Science, Cochrane) were... Read More about Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials.

768 STAKEHOLDER CO-DESIGN OF AN EXTENDED COMMUNITY PHARMACY ROLE AND SERVICE DELIVERY MODEL FOR PROVIDING OSTEOARTHRITS CARE: THE PHARMOA MODEL (2024)
Presentation / Conference Contribution
Holden, M., Stanford, C., Simkins, J., Babatunde, O. O., White, S., O'Brien, N., Chudyk, A., Dziedzic, K. S., Todd, A., Long, A., Walker, C., Cork, T., Cottrell, E., Edwards, J., Nicholls, E., Mallen, C., & Healey, E. L. (2024, April). 768 STAKEHOLDER CO-DESIGN OF AN EXTENDED COMMUNITY PHARMACY ROLE AND SERVICE DELIVERY MODEL FOR PROVIDING OSTEOARTHRITS CARE: THE PHARMOA MODEL. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

767 EXPLORING THE POTENTIAL EXTENDED ROLE OF COMMUNITY PHARMACY IN THE MANAGEMENT OF OSTEOARTHRITIS: SURVEYS AND INTERVIEWS WITH COMMUNITY PHARMACY STAFF AND OTHER HEALTHCARE PROFESSIONALS (2024)
Presentation / Conference Contribution
Simkins, J., Holden, M., Babatunde, O. O., White, S., Nicholls, E., Long, A., Dziedzic, K. S., Chudyk, A., Todd, A., Walker, C., Stanford, C., Cottrell, E., Edwards, J., Healey, E. L., Cork, T., Mallen, C., & O'Brien, N. (2024, April). 767 EXPLORING THE POTENTIAL EXTENDED ROLE OF COMMUNITY PHARMACY IN THE MANAGEMENT OF OSTEOARTHRITIS: SURVEYS AND INTERVIEWS WITH COMMUNITY PHARMACY STAFF AND OTHER HEALTHCARE PROFESSIONALS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

775 BRACING ACCEPTABILITY AND ADHERENCE FOR KNEE OSTEOARTHRITIS: FINDINGS FROM A QUALITATIVE STUDY IN THE PROP-OA MULTICENTRE TRIAL (2024)
Presentation / Conference Contribution
Jinks, C., Holden, M., Asaname, E., Bullock, L., Herron, D., Halliday, N., Armitt, G., Bathers, S., Birrell, F., Borrelli, B., Browell, R., Callaghan, M. J., Dobb, K., Dziedzic, K. S., Felson, D., Foster, N., Hartshorne, E., Huckfield, L., Humphries, K., Ingram, C., …Peat, G. (2024, April). 775 BRACING ACCEPTABILITY AND ADHERENCE FOR KNEE OSTEOARTHRITIS: FINDINGS FROM A QUALITATIVE STUDY IN THE PROP-OA MULTICENTRE TRIAL. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention (2024)
Journal Article
Siciliano, M., Bathers, S., Bentley, I., Bullock, L., Cherrington, A., Clark, E., Fleming, J., Jinks, C., Lewis, S., Mallen, C., Nicholls, E., O'Neill, T., Smith, J., Webb, D., Paskins, Z., & Iglesias-Urrutia, C. (in press). Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention. NIHR Open Research, 4(15), https://doi.org/10.3310/nihropenres.13575.1

Background
Digital health interventions (DHI) are associated with significant promise. In recent years, the need to assess the value of these healthcare technologies has motivated a debate regarding the suitability of existing economic evaluation me... Read More about Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention.

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., Dziedzic, K., Chudyk, A., Todd, A., Walker, C., Stanford, C., Cottrell, E., Edwards, J., Healey, E. L., Cork, T., Mallen, C., & O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction
Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.

Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) (2024)
Journal Article
Babatunde, O. O., Cottrell, E., White, S., Chudyk, A., Healey, E. L., Edwards, J., Nicholls, E., O’Brien, N., Todd, A., Walker, C., Stanford, C., Cork, T., Long, A., Simkins, J., Mallen, C. D., Dziedzic, K., & Holden, M. A. (2024). Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA). BMC Musculoskeletal Disorders, 25(1), Article 54. https://doi.org/10.1186/s12891-023-07105-2

Background
Osteoarthritis is a common, painful and disabling long-term condition. Delivery of high-quality guideline-informed osteoarthritis care that successfully promotes and maintains supported self-management is imperative. However, osteoarthrit... Read More about Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. (2024)
Journal Article
Bullock, L., Nicholls, E., Cherrington, A., Butler-Walley, S., Clark, E. M., Fleming, J., Leyland, S., Bentley, I., Thomas, S., Iglesias-Urrutia, C. P., Webb, D., Smith, J., Bathers, S., Lewis, S., Clifford, A., Siciliano, M., Protheroe, J., Ryan, S., Lefroy, J., Dale, N., …Paskins, Z. (2024). A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. NIHR Open Research, 4(14), 14. https://doi.org/10.3310/nihropenres.13571.1

BackgroundGood quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person's life, beliefs, and value... Read More about A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol..

WHAT DO PATIENTS WANT AND NEED FROM AN OSTEOARTHRITIS EXPLANATION: RESULTS FROM STAKEHOLDER CONSULTATION EXERCISE (2023)
Presentation / Conference Contribution
Jinks, C., Campbell, L., Croft, P., Dziedzic, K., Grossmann, H., Hadley-Barrows, T., Maddison, J., Main, C., McRobert, C., Nicholls, E., Paskins, Z., Peat, G., Porcheret, M., Protheroe, J., Quicke, J., Shivji, N., & Cottrell, E. (2023, December). WHAT DO PATIENTS WANT AND NEED FROM AN OSTEOARTHRITIS EXPLANATION: RESULTS FROM STAKEHOLDER CONSULTATION EXERCISE. Paper presented at SAPC ASM 2023, Brighton

Bone health assessment in adults with fragility fracture risk factors between 2002-2014: a retrospective cohort study. (2023)
Journal Article
Pradhan, A., Nicholls, E., Edwards, J., Welsh, V., & Paskins, Z. (2023). Bone health assessment in adults with fragility fracture risk factors between 2002-2014: a retrospective cohort study. British Journal of General Practice Open (BJGP Open), 8(1), Article 0084. https://doi.org/10.3399/BJGPO.2023.0084

Background: Lifetime risk of fragility fractures is 50% in post-menopausal women and 20% in men aged over 50 years. Identifying people at high risk facilitates early intervention and reduction of biopsychosocial morbidity associated with these fractu... Read More about Bone health assessment in adults with fragility fracture risk factors between 2002-2014: a retrospective cohort study..

Proactive review of patients taking opioid medicines for persistent pain led by pharmacists in primary care teams (PROMPPT): A feasibility study (2023)
Presentation / Conference Contribution
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Laing, L., Helliwell, T., Lancaster, G., Mallen, C. D., Avery, A., Knaggs, R., Pincus, T., & Jinks, C. (2023, May). Proactive review of patients taking opioid medicines for persistent pain led by pharmacists in primary care teams (PROMPPT): A feasibility study. Presented at BPS Annual Scientific Meeting 2023, Glasgow, Scotland, UK

Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial). (2023)
Journal Article
Foster, N. E., Nicholls, E., Holden, M. A., Healey, E. L., Hay, E. M., & trial team, T. B. (2023). Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial). Archives of Rehabilitation Research and Clinical Translation, 5(2), Article 100266. https://doi.org/10.1016/j.arrct.2023.100266

To investigate whether knee osteoarthritis (OA) related pain and function can be improved by offering enhanced physical therapist-led exercise interventions. Three-arm prospectively designed pragmatic randomized controlled trial. General practices an... Read More about Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial)..

Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis (2023)
Presentation / Conference Contribution
Jinks, C., Campbell, L., Croft, P., Dziedzic, K., Grossman, H., Maddison, J., Main, C., McRobert, C., Nicholls, E., Paskins, Z., Peat, G., Protheroe, J., Quicke, J., Shivji, N., & Cottrell, L. Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis

Purpose: Osteoarthritis (OA) is a major cause of pain and disability worldwide. Despite this and the existence of evidence-based guidelines, many patients and professionals lack clarity about the nature of OA and effective treatment strategies. Healt... Read More about Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis.

Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care (2022)
Journal Article
Watson, L., Belcher, J., Nicholls, E., Chandratre, P., Blagojevic-Bucknall, M., Hider, S., Lawton, S. A., Mallen, C. D., Muller, S., Rome, K., & Roddy, E. (2022). Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care. Rheumatology, 62(8), 2748-2756. https://doi.org/10.1093/rheumatology/keac706

Objective To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care. Methods In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices... Read More about Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care.