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Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care

Watson, Lorraine; Belcher, John; Nicholls, Elaine; Chandratre, Priyanka; Blagojevic-Bucknall, Milica; Hider, Samantha; Lawton, Sarah A; Mallen, Christian D; Muller, Sara; Rome, Keith; Roddy, Edward


Priyanka Chandratre

Keith Rome


Objective To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care. Methods In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices completed the Gout Impact Scale (GIS; scale 0–100), 36-item Short Form Physical Function subscale (PF-10; 0–100) and HAQ Disability Index (HAQ-DI; 0–3) via postal questionnaires at baseline and 6, 12, 24 and 36 months. Linear mixed modelling was used to investigate factors associated with changes in HRQOL over 3 years. Results A total of 1184 participants responded at baseline (adjusted response 65.6%); 990 (83.6%) were male, with a mean age of 65.6 years (s.d. 12.5). A total of 818, 721, 696 and 605 responded at 6, 12, 24 and 36 months, respectively. Factors associated with worse disease-specific and generic HRQOL over 3 years were flare frequency (five or more flares; GIS subscales, PF-10), oligo/polyarticular flares (GIS subscales, PF-10, HAQ-DI), worse pain (GIS subscales, PF-10, HAQ-DI), body pain (GIS subscales, PF-10, HAQ-DI) and more severe depression (GIS subscales, PF-10, HAQ-DI) (P ≤ 0.05). More severe anxiety was associated with worse disease-specific HRQOL only (GIS subscales). Older age (PF-10), being female (PF-10, HAQ-DI) and BMI (HAQ-DI) were associated with worse generic HRQOL (P ≤ 0.05). Conclusion Gout-specific, comorbid and sociodemographic factors were associated with change in HRQOL over a 3-year period, highlighting people at risk of worse outcomes who could be targeted for interventions.

Journal Article Type Article
Acceptance Date Dec 2, 2022
Online Publication Date Dec 21, 2022
Publication Date Dec 21, 2022
Publicly Available Date May 30, 2023
Journal Rheumatology
Print ISSN 1462-0324
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 62
Issue 8
Pages 2748-2756
Keywords Pharmacology (medical), Rheumatology
Publisher URL
Additional Information © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.
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