All Outputs (70)

Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials (2024)
Journal Article
Holden, M. A., Murphy, M., Simkins, J., Thomas, M. J., Huckfield, L., Quicke, J. G., …Peat, G. (2024). Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.08.010

Objective
To identify and synthesise the content of knee bracing interventions in randomised controlled trials (RCTs) of knee osteoarthritis (OA).

Design
In this scoping review, three electronic databases (PubMed, Web of Science, Cochrane) were... Read More about Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials.

Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention (2024)
Journal Article
Siciliano, M., Bathers, S., Bentley, I., Bullock, L., Cherrington, A., Clark, E., …Iglesias-Urrutia, C. (in press). Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention. NIHR Open Research, 4(15), https://doi.org/10.3310/nihropenres.13575.1

Background
Digital health interventions (DHI) are associated with significant promise. In recent years, the need to assess the value of these healthcare technologies has motivated a debate regarding the suitability of existing economic evaluation me... Read More about Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention.

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., …O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction
Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.

Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) (2024)
Journal Article
Babatunde, O. O., Cottrell, E., White, S., Chudyk, A., Healey, E. L., Edwards, J., …Holden, M. A. (2024). Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA). BMC Musculoskeletal Disorders, 25(1), Article 54. https://doi.org/10.1186/s12891-023-07105-2

Background
Osteoarthritis is a common, painful and disabling long-term condition. Delivery of high-quality guideline-informed osteoarthritis care that successfully promotes and maintains supported self-management is imperative. However, osteoarthrit... Read More about Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. (2024)
Journal Article
Bullock, L., Nicholls, E., Cherrington, A., Butler-Walley, S., Clark, E. M., Fleming, J., …Paskins, Z. (2024). A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. NIHR Open Research, 4(14), 14. https://doi.org/10.3310/nihropenres.13571.1

BackgroundGood quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person's life, beliefs, and value... Read More about A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol..

Bone health assessment in adults with fragility fracture risk factors between 2002-2014: a retrospective cohort study. (2023)
Journal Article
Pradhan, A., Nicholls, E., Edwards, J., Welsh, V., & Paskins, Z. (2023). Bone health assessment in adults with fragility fracture risk factors between 2002-2014: a retrospective cohort study. British Journal of General Practice Open (BJGP Open), 8(1), Article 0084. https://doi.org/10.3399/BJGPO.2023.0084

Background: Lifetime risk of fragility fractures is 50% in post-menopausal women and 20% in men aged over 50 years. Identifying people at high risk facilitates early intervention and reduction of biopsychosocial morbidity associated with these fractu... Read More about Bone health assessment in adults with fragility fracture risk factors between 2002-2014: a retrospective cohort study..

Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial). (2023)
Journal Article
Foster, N. E., Nicholls, E., Holden, M. A., Healey, E. L., Hay, E. M., & trial team, T. B. (2023). Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial). Archives of Rehabilitation Research and Clinical Translation, 5(2), Article 100266. https://doi.org/10.1016/j.arrct.2023.100266

To investigate whether knee osteoarthritis (OA) related pain and function can be improved by offering enhanced physical therapist-led exercise interventions. Three-arm prospectively designed pragmatic randomized controlled trial. General practices an... Read More about Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial)..

Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis (2023)
Journal Article
Jinks, C., Campbell, L., Croft, P., Dziedzic, K., Grossman, H., Maddison, J., …Cottrell, L. (2023). Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis. Osteoarthritis and Cartilage, 31(5), 711-712. https://doi.org/10.1016/j.joca.2023.02.064

Purpose: Osteoarthritis (OA) is a major cause of pain and disability worldwide. Despite this and the existence of evidence-based guidelines, many patients and professionals lack clarity about the nature of OA and effective treatment strategies. Healt... Read More about Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis.

Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care (2022)
Journal Article
Watson, L., Belcher, J., Nicholls, E., Chandratre, P., Blagojevic-Bucknall, M., Hider, S., …Roddy, E. (2022). Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care. Rheumatology, 62(8), 2748-2756. https://doi.org/10.1093/rheumatology/keac706

Objective To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care. Methods In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices... Read More about Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care.

P077 Developing a better explanation of osteoarthritis: results from a conjoint analysis of patient preferences (2022)
Journal Article
Shivji, Protheroe, Paskins, Main, C., Jinks, & Nicholls. (2022). P077 Developing a better explanation of osteoarthritis: results from a conjoint analysis of patient preferences. Rheumatology, https://doi.org/10.1093/rheumatology/keac133.076

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background/Aims</jats:title> <jats:p>Despite the negative impact of osteoarthritis (OA) and existence of evidence-based guidelines, many patients and professionals lack clarity about the nature... Read More about P077 Developing a better explanation of osteoarthritis: results from a conjoint analysis of patient preferences.

THE SUBGROUP EFFECTS OF NON-SURGICAL AND NON-PHARMACOLOGICAL TREATMENT OF PATIENTS WITH HAND OSTEOARTHRITIS - A PROTOCOL FOR AN INDIVIDUAL PATIENT DATA META-ANALYSIS IN THE OA TRIAL BANK (2022)
Journal Article
Thissen, G., van Middelkoop, M., Colaris, J., Selles, R., Dziedzic, K., Nicholls, E., & Bierma-Zeinstra, S. (2022). THE SUBGROUP EFFECTS OF NON-SURGICAL AND NON-PHARMACOLOGICAL TREATMENT OF PATIENTS WITH HAND OSTEOARTHRITIS - A PROTOCOL FOR AN INDIVIDUAL PATIENT DATA META-ANALYSIS IN THE OA TRIAL BANK. Osteoarthritis and Cartilage, 30(S1), S423. https://doi.org/10.1016/j.joca.2022.02.576

THE SUBGROUP EFFECTS OF SURGICAL TREATMENT OF PATIENT WITH HAND OSTEOARTHRITIS - A PROTOCOL FOR AN INDIVIDUAL PATIENT DATA META-ANALYSIS IN THE OA TRIAL BANK (2022)
Journal Article
Thissen, G., Middelkoop van, M., Colaris, J., Selles, R., Dziedzic, K., Nicholls, E., & Bierma-Zeinstra, S. (2022). THE SUBGROUP EFFECTS OF SURGICAL TREATMENT OF PATIENT WITH HAND OSTEOARTHRITIS - A PROTOCOL FOR AN INDIVIDUAL PATIENT DATA META-ANALYSIS IN THE OA TRIAL BANK. Osteoarthritis and Cartilage, 30, S423. https://doi.org/10.1016/j.joca.2022.02.577

Purpose: The hand joints are frequently affected by osteoarthritis (OA) in the adult population. Patients whose pain and disability are persistent may benefit from surgical treatment. However, based on current evidence, small and moderate effect size... Read More about THE SUBGROUP EFFECTS OF SURGICAL TREATMENT OF PATIENT WITH HAND OSTEOARTHRITIS - A PROTOCOL FOR AN INDIVIDUAL PATIENT DATA META-ANALYSIS IN THE OA TRIAL BANK.

Subgroup effects of non-surgical and non-pharmacological treatment of patients with hand osteoarthritis: a protocol for an individual patient data meta-analysis. (2022)
Journal Article
Dziedzic, & Nicholls. (2022). Subgroup effects of non-surgical and non-pharmacological treatment of patients with hand osteoarthritis: a protocol for an individual patient data meta-analysis. BMJ Open, e057156 - ?. https://doi.org/10.1136/bmjopen-2021-057156

INTRODUCTION: Hand osteoarthritis (OA) is a common joint disorder in the adult population. No cure for hand OA is known yet, but treatment aims to reduce symptoms. Non-surgical and non-pharmacological therapy interventions can include splinting, pati... Read More about Subgroup effects of non-surgical and non-pharmacological treatment of patients with hand osteoarthritis: a protocol for an individual patient data meta-analysis..

Integrating case-finding and initial management for osteoarthritis, anxiety, and depression into primary care long-term condition reviews: results from the ENHANCE pilot trial. (2021)
Journal Article
Healey, E. L., Mallen, C. D., Chew-Graham, C. A., Nicholls, E., Lewis, M., Lawton, S. A., …Jinks, C. (2022). Integrating case-finding and initial management for osteoarthritis, anxiety, and depression into primary care long-term condition reviews: results from the ENHANCE pilot trial. Family Practice, 39(4), 592–602. https://doi.org/10.1093/fampra/cmab113

Background: Multimorbidity is increasingly the norm; however, primary care remains focused on single diseases. Osteoarthritis, anxiety, and depression are frequently comorbid with other long-term conditions (LTCs), but rarely prioritized by clinician... Read More about Integrating case-finding and initial management for osteoarthritis, anxiety, and depression into primary care long-term condition reviews: results from the ENHANCE pilot trial..

Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. (2021)
Journal Article
Holden, M., Callaghan, M., Felson, D., Birrell, F., Nicholls, E., Jowett, S., …Peat, G. (2021). Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. BMJ Open, 11(3), Article e048196. https://doi.org/10.1136/bmjopen-2020-048196

BACKGROUND: Brace effectiveness for knee osteoarthritis (OA) remains unclear and international guidelines offer conflicting recommendations. Our trial will determine the clinical and cost-effectiveness of adding knee bracing (matched to patients' cli... Read More about Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial..

Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care (2020)
Journal Article
Muller, Watson, Belcher, Mallen, Roddy, & Nicholls. (2020). Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care. Arthritis and Rheumatology, 72(11), 1928-1935. https://doi.org/10.1002/art.41476

Objective
To investigate the existence of distinct classes of gout flare trajectories and compare their gout-specific, comorbid, and sociodemographic characteristics.

Methods
In a prospective cohort study, adults with gout who were registered wi... Read More about Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care.

P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care (2020)
Journal Article
Watson, L., Belcher, J., Nicholls, E., Chandratre, P., Blagojevic-Bucknall, M., Hider, S., …Roddy, E. (2020). P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care. Rheumatology, 59(Supplement_2), https://doi.org/10.1093/rheumatology/keaa111.137

Background
Gout affects 2.5% of adults in the UK but is often poorly managed. It can impair health-related quality of life (HRQOL), yet little is known about which people with gout are at risk of worse outcomes. We investigated factors associated wi... Read More about P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care.

Relative prevalence and distribution of knee, hand and foot symptomatic osteoarthritis subtypes in an English population (2020)
Journal Article
Peat, G., Rathod-Mistry, T., Paskins, Z., Marshall, M., Thomas, M. J., Menz, H. B., …Dziedzic, K. S. (2020). Relative prevalence and distribution of knee, hand and foot symptomatic osteoarthritis subtypes in an English population. Musculoskeletal Care, 18(2), 219-224. https://doi.org/10.1002/msc.1457

In this brief report, we used data from a series of three related cohorts on pain and osteoarthritis (OA) of the knee, hand and foot, which were conducted in North Staffordshire, England. We used a common approach for sampling, data collection and co... Read More about Relative prevalence and distribution of knee, hand and foot symptomatic osteoarthritis subtypes in an English population.

Longitudinal validity of using digital hand photographs for assessing hand osteoarthritis progression over 7 years in community-dwelling older adults with hand pain (2019)
Journal Article
Marshall, M., Jonsson, H., Helgadottir, G. P., Nicholls, E., Myers, H., Jansen, V., & van der Windt, D. (2019). Longitudinal validity of using digital hand photographs for assessing hand osteoarthritis progression over 7 years in community-dwelling older adults with hand pain. BMC Musculoskeletal Disorders, 20, Article 484. https://doi.org/10.1186/s12891-019-2829-0

Background
To determine the longitudinal construct validity of assessing hand OA progression on digital photographs over 7?years compared with progression determined from radiographs, clinical features and change in symptoms.

Methods
Participant... Read More about Longitudinal validity of using digital hand photographs for assessing hand osteoarthritis progression over 7 years in community-dwelling older adults with hand pain.

Short-term recovery trajectories of acute flares in knee pain: a UK-Netherlands multi-centre prospective cohort analysis (2019)
Journal Article
Thomas, M., Yu, D., Nicholls, E., Bierma‐Zeinstra, S., Conaghan, P. G., Stoner, K. J., …Peat, G. (2020). Short-term recovery trajectories of acute flares in knee pain: a UK-Netherlands multi-centre prospective cohort analysis. Arthritis Care and Research, 72(12), 1687-1692. https://doi.org/10.1002/acr.24088

Objective
To identify distinct recovery trajectories of acute flares of knee pain and associated participant characteristics.

Methods
Data were from FLARE RCT, a multicentre trial in 27 primary care centres in UK and Netherlands of three regimes... Read More about Short-term recovery trajectories of acute flares in knee pain: a UK-Netherlands multi-centre prospective cohort analysis.