Skip to main content

Research Repository

Advanced Search

All Outputs (54)

SBOL-OWL: An ontological approach for formal and semantic representation of synthetic biology information (2019)
Journal Article
Misirli. (2019). SBOL-OWL: An ontological approach for formal and semantic representation of synthetic biology information. ACS synthetic biology, 1498-1514. https://doi.org/10.1021/acssynbio.8b00532

Standard representation of data is key for the reproducibility of designs in synthetic biology. The Synthetic Biology Open Language (SBOL) has already emerged as a data standard to represent information about genetic circuits, and it is based on capt... Read More about SBOL-OWL: An ontological approach for formal and semantic representation of synthetic biology information.

Synthetic Biology Open Language (SBOL) Version 2.3. (2019)
Journal Article
Misirli. (2019). Synthetic Biology Open Language (SBOL) Version 2.3. Journal of Integrative Bioinformatics, https://doi.org/10.1515/jib-2019-0025

Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long... Read More about Synthetic Biology Open Language (SBOL) Version 2.3..

Receiver Design Using Genetic Circuits in Molecular Communication (2019)
Presentation / Conference
Misirli. (2019, April). Receiver Design Using Genetic Circuits in Molecular Communication. Presented at 4th workshop on Molecular Communications, Linz, Austria

Understanding the dynamics of molecular communications between cells and intracellular response is crucial to create predictable cellular applications. When the propagation mechanism is diffusion based, the arrival histogram of molecules becomes heav... Read More about Receiver Design Using Genetic Circuits in Molecular Communication.

A Genetic Circuit Compiler: Generating Combinatorial Genetic Circuits with Web Semantics and Inference (2018)
Journal Article
Misirli. (2018). A Genetic Circuit Compiler: Generating Combinatorial Genetic Circuits with Web Semantics and Inference. ACS synthetic biology, 2812-2823. https://doi.org/10.1021/acssynbio.8b00201

A central strategy of synthetic biology is to understand the basic processes of living creatures through engineering organisms using the same building blocks. Biological machines described in terms of parts can be studied by computer simulation in an... Read More about A Genetic Circuit Compiler: Generating Combinatorial Genetic Circuits with Web Semantics and Inference.

Harmonizing semantic annotations for computational models in biology (2018)
Journal Article
Misirli. (2018). Harmonizing semantic annotations for computational models in biology. Briefings in bioinformatics, bby087 - bby087. https://doi.org/10.1093/bib/bby087

Life science researchers use computational models to articulate and test hypotheses about the behavior of biological systems. Semantic annotation is a critical component for enhancing the interoperability and reusability of such models as well as for... Read More about Harmonizing semantic annotations for computational models in biology.

A computational workflow for the automated generation of models of genetic designs (2018)
Journal Article
Misirli. (2018). A computational workflow for the automated generation of models of genetic designs. ACS synthetic biology, 1548-1559. https://doi.org/10.1021/acssynbio.7b00459

Computational models are essential to engineer predictable biological systems and to scale up this process for complex systems. Computational modelling often requires expert knowledge and data to build models. Clearly, manual creation of models is no... Read More about A computational workflow for the automated generation of models of genetic designs.

Synthetic Biology Open Language (SBOL) Version 2.2.0. (2018)
Journal Article
Misirli. (2018). Synthetic Biology Open Language (SBOL) Version 2.2.0. Journal of Integrative Bioinformatics, https://doi.org/10.1515/jib-2018-0001

Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long... Read More about Synthetic Biology Open Language (SBOL) Version 2.2.0..

SynBioHub: A Standards-Enabled Design Repository for Synthetic Biology. (2018)
Journal Article
McLaughlin, J., Ofiteru, I., Goñi Moreno, A., Zundel, Z., Misirli, G., Zhang, M., …Myers, C. (2018). SynBioHub: A Standards-Enabled Design Repository for Synthetic Biology. ACS synthetic biology, 682-688. https://doi.org/10.1021/acssynbio.7b00403

The SynBioHub repository (synbiohub.org) is an open-source software project which facilitates the sharing of information about engineered biological systems. SynBioHub provides computational access for software and data integration, and a graphical u... Read More about SynBioHub: A Standards-Enabled Design Repository for Synthetic Biology..

Standard Enabled Model Generator for Genetic Circuit Design (2017)
Presentation / Conference
Myers, C., Wipat, A., Misirli, G., Nguyen, T., & McLaughlin, J. (2017, August). Standard Enabled Model Generator for Genetic Circuit Design. Presented at 9th International Workshop on Bio-Design Automation, Pittsburgh

A standard-enabled workflow for synthetic biology. (2017)
Journal Article
Mısırlı, G., Nguyen, T., Oberortner, E., Samineni, M., Wipat, A., Zhang, M., …Kuwahara, H. (2017). A standard-enabled workflow for synthetic biology. Transactions, 793 - 803. https://doi.org/10.1042/BST20160347

A synthetic biology workflow is composed of data repositories that provide information about genetic parts, sequence-level design tools to compose these parts into circuits, visualization tools to depict these designs, genetic design tools to select... Read More about A standard-enabled workflow for synthetic biology..

Constructing Synthetic Biology Workflows in the Cloud (2017)
Journal Article
Misirli. (2017). Constructing Synthetic Biology Workflows in the Cloud. Engineering Biology, 61-65. https://doi.org/10.1049/enb.2017.0001

The synthetic biology design process has traditionally been heavily dependent upon manual searching, acquisition and integration of existing biological data. A large amount of such data is already available from Internet-based resources, but data exc... Read More about Constructing Synthetic Biology Workflows in the Cloud.

The SBOL Stack: A Platform for Storing, Publishing, and Sharing Synthetic Biology Designs. (2016)
Journal Article
Wipat, A., Hallinan, J., Madsen, C., McLaughlin, J., Mısırlı, G., Pocock, M., & Flanagan, K. (2016). The SBOL Stack: A Platform for Storing, Publishing, and Sharing Synthetic Biology Designs. ACS synthetic biology, 487 - 497. https://doi.org/10.1021/acssynbio.5b00210

Recently, synthetic biologists have developed the Synthetic Biology Open Language (SBOL), a data exchange standard for descriptions of genetic parts, devices, modules, and systems. The goals of this standard are to allow scientists to exchange design... Read More about The SBOL Stack: A Platform for Storing, Publishing, and Sharing Synthetic Biology Designs..

Data Integration and Mining for Synthetic Biology Design. (2016)
Journal Article
Mısırlı, G., Hallinan, J., Pocock, M., Lord, P., McLaughlin, J., Sauro, H., & Wipat, A. (2016). Data Integration and Mining for Synthetic Biology Design. ACS synthetic biology, 1086 - 1097. https://doi.org/10.1021/acssynbio.5b00295

One aim of synthetic biologists is to create novel and predictable biological systems from simpler modular parts. This approach is currently hampered by a lack of well-defined and characterized parts and devices. However, there is a wealth of existin... Read More about Data Integration and Mining for Synthetic Biology Design..

libSBOLj 2.0: A Java Library to Support SBOL 2.0 (2016)
Journal Article
Misirli. (2016). libSBOLj 2.0: A Java Library to Support SBOL 2.0. IEEE Life Sciences Letters, 34 - 37. https://doi.org/10.1109/LLS.2016.2546546

The Synthetic Biology Open Language (SBOL) is an emerging data standard for representing synthetic biology designs. The goal of SBOL is to improve the reproducibility of these designs and their electronic exchange between researchers and/or genetic d... Read More about libSBOLj 2.0: A Java Library to Support SBOL 2.0.

Annotation of rule-based models with formal semantics to enable creation, analysis, reuse and visualization. (2015)
Journal Article
Gilfellon, O., Honorato-Zimmer, R., Pocock, M., Madsen, C., Waites, W., Cavaliere, M., …Wipat, A. (2015). Annotation of rule-based models with formal semantics to enable creation, analysis, reuse and visualization. Bioinformatics, 908 - 917. https://doi.org/10.1093/bioinformatics/btv660

MOTIVATION: Biological systems are complex and challenging to model and therefore model reuse is highly desirable. To promote model reuse, models should include both information about the specifics of simulations and the underlying biology in the for... Read More about Annotation of rule-based models with formal semantics to enable creation, analysis, reuse and visualization..