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All Outputs (25)

Safeguarding community-centred global health research during crises. (2023)
Journal Article
Agampodi, T., Nuwangi, H., Gunasekara, S., Mallawaarachchi, A., Price, H. P., Dikomitis, L., & Agampodi, S. (2023). Safeguarding community-centred global health research during crises. BMJ Global Health, 8(8), Article e013304. https://doi.org/10.1136/bmjgh-2023-013304

Summary box Global health researchers face multiple challenges in proceeding with research programmes during crises, including ethical and safety questions, equitable participation of community members and the collection of robust data. In Sri La... Read More about Safeguarding community-centred global health research during crises..

The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review (2023)
Journal Article
Nuwangi, H., Agampodi, T. C., Price, H. P., Shepherd, T., Weerakoon, K. G., & Agampodi, S. B. (2023). The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review. PloS one, 18(5), Article ARTN e0285663. https://doi.org/10.1371/journal.pone.0285663

Leishmaniasis is a neglected tropical disease with three main clinical types; cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). CL and MCL are considered to be highly stigmatizing due to potentially dis... Read More about The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review.

Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits (2023)
Journal Article
Abebe, H., Zerihun, Z., Mallen, C., Price, H., Mulugeta, A., & Taffere, G. (2023). Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits. Journal of Public Health, https://doi.org/10.1007/s10389-022-01799-9

Background Community engagement in research has gained momentum as people have realised the importance and value it brings to research. However, a lack of standardization in the engagement approach has been reported in the literature. This systemati... Read More about Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits.

Rewriting the history of leishmaniasis in Sri Lanka: An untold story since 1904. (2022)
Journal Article
Nuwangi, H., Weerakoon, K., Agampodi, T., Price, H., Dikomitis, L., & Agampodi, S. (2022). Rewriting the history of leishmaniasis in Sri Lanka: An untold story since 1904. PLoS Neglected Tropical Diseases, e0010918 - ?. https://doi.org/10.1371/journal.pntd.0010918

Leishmaniasis is widely considered a disease that emerged in Sri Lanka in the 1990s. However, a comprehensive case report from 1904 suggests that the presence of Leishmaniasis was well demonstrated in Sri Lanka long before that. The Annual Administra... Read More about Rewriting the history of leishmaniasis in Sri Lanka: An untold story since 1904..

Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review (2022)
Journal Article
Polidano, K., Wenning, B., Ruiz-Cadavid, A., Dawaishan, B., Panchal, J., Gunasekara, S., …Dikomitis, L. (2022). Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review. Social Sciences, 11(10), Article 490. https://doi.org/10.3390/socsci11100490

We reviewed the evidence on community-based interventions for the prevention and control of cutaneous leishmaniasis (CL). Community initiatives tailored towards awareness and mobilisation are regarded as a priority area in the Neglected Tropical Dise... Read More about Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review.

Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review. (2022)
Journal Article
Wenning, B., Price, H., Nuwangi, H., Reda, K., Viana, G., Andras, A., …Ehsanullah, R. (2022). Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review. Global Health Research and Policy, 7, Article 34. https://doi.org/10.1186/s41256-022-00266-y

BACKGROUND: More than one million people each year become infected by parasites that cause the disease cutaneous leishmaniasis (CL). This disease manifests as one or more skin lesions or ulcers that are slow to heal with variable response rates to dr... Read More about Exploring the cultural effects of gender on perceptions of cutaneous leishmaniasis: a systematic literature review..

Serological and molecular detection of Leishmania species in dog peripheral blood from Bobo-Dioulasso city, a confirmation of canine leishmaniasis enzootic area for Burkina Faso. (2022)
Journal Article
Sangaré, I., Yameogo, B., Koala, L., Ouari, A., Nikièma, A., Fournet, F., …Djibougou, A. (2022). Serological and molecular detection of Leishmania species in dog peripheral blood from Bobo-Dioulasso city, a confirmation of canine leishmaniasis enzootic area for Burkina Faso. Infection, Genetics and Evolution, 103, Article 105327. https://doi.org/10.1016/j.meegid.2022.105327

Canine leishmaniasis is increasingly reported worldwide and represent a threat to both animal and human health. In a previous pilot study conducted in Bobo-Dioulasso, the second town of Burkina Faso, we reported five cases of canine leishmaniasis. Wi... Read More about Serological and molecular detection of Leishmania species in dog peripheral blood from Bobo-Dioulasso city, a confirmation of canine leishmaniasis enzootic area for Burkina Faso..

Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka. (2022)
Journal Article
Gunasekara, S., Nuwangi, H., Wickramasinghe, N., Weerakoon, K., Price, H., Dikomitis, L., & Agampodi, S. (2022). Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka. Pathogens an international, open access journal of pathogens and pathogen-host interactions, 11(6), Article 680. https://doi.org/10.3390/pathogens11060680

Having an effective surveillance system is imperative to take timely and appropriate actions for disease control and prevention. In Sri Lanka, leishmaniasis was declared as a notifiable disease in 2008. This paper presents a comprehensive compilation... Read More about Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka..

Current and future strategies against cutaneous parasites (2022)
Journal Article
Man, E., Price, H., & Hoskins, C. (2022). Current and future strategies against cutaneous parasites. Pharmaceutical Research, 631-651. https://doi.org/10.1007/s11095-022-03232-y

Cutaneous parasites are identified by their specific cutaneous symptoms which are elicited based on the parasite's interactions with the host. Standard anti-parasitic treatments primarily focus on the use of specific drugs to disrupt the regular func... Read More about Current and future strategies against cutaneous parasites.

Community engagement in cutaneous leishmaniasis research in Brazil, Ethiopia, and Sri Lanka: a decolonial approach for global health (2022)
Journal Article
Polidano, K., Agampodi, T., Parton, L., Agampodi, S., Haileselassie, B., Lalani, J., …Zerihun, Z. (2022). Community engagement in cutaneous leishmaniasis research in Brazil, Ethiopia, and Sri Lanka: a decolonial approach for global health. Frontiers in Public Health, 10, https://doi.org/10.3389/fpubh.2022.823844

Cutaneous leishmaniasis (CL) is a parasitic skin disease endemic in at least 88 countries where it presents an urgent, albeit often "neglected" public health problem. In this paper, we discuss our model of decolonial community engagement in the ECLIP... Read More about Community engagement in cutaneous leishmaniasis research in Brazil, Ethiopia, and Sri Lanka: a decolonial approach for global health.

Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases (2021)
Journal Article
Hameed, H., King, E., Doleckova, K., Bartholomew, B., Hollinshead, J., Mbye, H., …Price, H. (2021). Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases. Pharmaceuticals, 14(3), 1-17. https://doi.org/10.3390/ph14030227

The use of plant-derived natural products for the treatment of tropical parasitic diseases often has ethnopharmacological origins. As such, plants grown in temperate regions remain largely untested for novel anti-parasitic activities. We describe her... Read More about Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases.

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model (2020)
Journal Article
Paape, D., Prendergast, C., Price, H., Doehl, J., & Smith, D. (2020). Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model. Parasites and Vectors, 13, Article 132. https://doi.org/10.1186/s13071-020-3999-1

Background: Proving that specifc genes are essential for the intracellular viability of Leishmania parasites within macrophages remains a challenge for the identifcation of suitable targets for drug development. This is especially evident in the ab... Read More about Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model (2020)
Journal Article
Agostino, V., Trinconi, C., Galuppo, M., Price, H., & Uliana, S. (2020). Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model. Acta tropica, 206, Article 105444. https://doi.org/10.1016/j.actatropica.2020.105444

New drugs for the treatment of human leishmaniasis are urgently needed, considering the limitations of current available options. However, pre-clinical evaluation of drug candidates for leishmaniasis is challenging. The use of luciferase-expressing p... Read More about Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model.

Nanoparticle-mediated magnetic hyperthermia is an effective method for killing the human-infective protozoan parasite Leishmania mexicana in vitro (2019)
Journal Article
Berry, S., Walker, K., Hoskins, C., Telling, N., & Price, H. (2019). Nanoparticle-mediated magnetic hyperthermia is an effective method for killing the human-infective protozoan parasite Leishmania mexicana in vitro. Scientific reports, 9, Article 1059. https://doi.org/10.1038/s41598-018-37670-9

Cutaneous leishmaniasis is a neglected tropical disease characterized by disfguring skin lesions. Current chemotherapeutic options depend on toxic, expensive drugs that are both difcult to administer and becoming less efective due to increasing level... Read More about Nanoparticle-mediated magnetic hyperthermia is an effective method for killing the human-infective protozoan parasite Leishmania mexicana in vitro.

The role of heparan sulfate in host macrophage infection by Leishmania species (2018)
Journal Article
Maciej-Hulme, M., Skidmore, M., & Price, H. (2018). The role of heparan sulfate in host macrophage infection by Leishmania species. Transactions, 46(4), 789-796. https://doi.org/10.1042/BST20170398

The leishmaniases are a group of neglected tropical diseases caused by parasites from the Leishmania genus. More than 20 Leishmania species are responsible for human disease, causing a broad spectrum of symptoms ranging from cutaneous lesions to a fa... Read More about The role of heparan sulfate in host macrophage infection by Leishmania species.

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. (2018)
Journal Article
Price, H., Berry, S., Hameed, H., Thomason, A., Maciej-Hulme, M., Saif Abou-Akkada, S., & Horrocks, P. (2018). Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. PLoS Neglected Tropical Diseases, 12(7), Article e0006639 . https://doi.org/10.1371/journal.pntd.0006639

The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging. New th... Read More about Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays..

Schistosoma mansoni cercarial elastase (SmCE): differences in immunogenic properties of native and recombinant forms (2017)
Journal Article
El-Faham, M., Wheatcroft-Francklow, K., Price, H., Sayers, J., & Doenhoff, M. (2017). Schistosoma mansoni cercarial elastase (SmCE): differences in immunogenic properties of native and recombinant forms. Parasitology, 144(10), 1356-1364. https://doi.org/10.1017/s0031182017000658

The Schistosoma mansoni cercarial elastase (SmCE) has previously been shown to be poorly immunogenic in mice. However, a minority of mice were able to produce antibodies against SmCE after multiple immunizations with crude preparations containing the... Read More about Schistosoma mansoni cercarial elastase (SmCE): differences in immunogenic properties of native and recombinant forms.

First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa) (2016)
Journal Article
Sangaré, I., Dabiré, R., Guiguemdé, R., Fournet, F., Price, H., Djibougou, A., …Banuls, A. (2016). First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa). Research Journal of Parasitology, 12(1), 27-32. https://doi.org/10.3923/jp.2017.27.32

Background and Objective: Human Visceral Leishmaniasis (HVL) is a systemic neglected tropical diseases and potentially lethal disease caused by infection with protozoan parasites of the Leishmania genus. In the causal, agent of HVL is L. infantum and... Read More about First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa).