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All Outputs (17)

The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review (2023)
Journal Article
Nuwangi, H., Agampodi, T. C., Price, H. P., Shepherd, T., Weerakoon, K. G., & Agampodi, S. B. (2023). The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review. PloS one, 18(5), Article ARTN e0285663. https://doi.org/10.1371/journal.pone.0285663

Leishmaniasis is a neglected tropical disease with three main clinical types; cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). CL and MCL are considered to be highly stigmatizing due to potentially dis... Read More about The stigma associated with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL): A protocol for a systematic review.

Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits (2023)
Journal Article
Abebe, H., Zerihun, Z., Mallen, C., Price, H., Mulugeta, A., & Taffere, G. (2023). Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits. Journal of Public Health, https://doi.org/10.1007/s10389-022-01799-9

Background Community engagement in research has gained momentum as people have realised the importance and value it brings to research. However, a lack of standardization in the engagement approach has been reported in the literature. This systemati... Read More about Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits.

Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review (2022)
Journal Article
Polidano, K., Wenning, B., Ruiz-Cadavid, A., Dawaishan, B., Panchal, J., Gunasekara, S., …Dikomitis, L. (2022). Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review. Social Sciences, 11(10), Article 490. https://doi.org/10.3390/socsci11100490

We reviewed the evidence on community-based interventions for the prevention and control of cutaneous leishmaniasis (CL). Community initiatives tailored towards awareness and mobilisation are regarded as a priority area in the Neglected Tropical Dise... Read More about Community-Based Interventions for the Prevention and Control of Cutaneous Leishmaniasis: A Systematic Review.

Serological and molecular detection of Leishmania species in dog peripheral blood from Bobo-Dioulasso city, a confirmation of canine leishmaniasis enzootic area for Burkina Faso. (2022)
Journal Article
Sangaré, I., Yameogo, B., Koala, L., Ouari, A., Nikièma, A., Fournet, F., …Djibougou, A. (2022). Serological and molecular detection of Leishmania species in dog peripheral blood from Bobo-Dioulasso city, a confirmation of canine leishmaniasis enzootic area for Burkina Faso. Infection, Genetics and Evolution, 103, Article 105327. https://doi.org/10.1016/j.meegid.2022.105327

Canine leishmaniasis is increasingly reported worldwide and represent a threat to both animal and human health. In a previous pilot study conducted in Bobo-Dioulasso, the second town of Burkina Faso, we reported five cases of canine leishmaniasis. Wi... Read More about Serological and molecular detection of Leishmania species in dog peripheral blood from Bobo-Dioulasso city, a confirmation of canine leishmaniasis enzootic area for Burkina Faso..

Current and future strategies against cutaneous parasites (2022)
Journal Article
Man, E., Price, H., & Hoskins, C. (2022). Current and future strategies against cutaneous parasites. Pharmaceutical Research, 631-651. https://doi.org/10.1007/s11095-022-03232-y

Cutaneous parasites are identified by their specific cutaneous symptoms which are elicited based on the parasite's interactions with the host. Standard anti-parasitic treatments primarily focus on the use of specific drugs to disrupt the regular func... Read More about Current and future strategies against cutaneous parasites.

Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases (2021)
Journal Article
Hameed, H., King, E., Doleckova, K., Bartholomew, B., Hollinshead, J., Mbye, H., …Price, H. (2021). Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases. Pharmaceuticals, 14(3), 1-17. https://doi.org/10.3390/ph14030227

The use of plant-derived natural products for the treatment of tropical parasitic diseases often has ethnopharmacological origins. As such, plants grown in temperate regions remain largely untested for novel anti-parasitic activities. We describe her... Read More about Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases.

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model (2020)
Journal Article
Paape, D., Prendergast, C., Price, H., Doehl, J., & Smith, D. (2020). Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model. Parasites and Vectors, 13, Article 132. https://doi.org/10.1186/s13071-020-3999-1

Background: Proving that specifc genes are essential for the intracellular viability of Leishmania parasites within macrophages remains a challenge for the identifcation of suitable targets for drug development. This is especially evident in the ab... Read More about Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model (2020)
Journal Article
Agostino, V., Trinconi, C., Galuppo, M., Price, H., & Uliana, S. (2020). Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model. Acta tropica, 206, Article 105444. https://doi.org/10.1016/j.actatropica.2020.105444

New drugs for the treatment of human leishmaniasis are urgently needed, considering the limitations of current available options. However, pre-clinical evaluation of drug candidates for leishmaniasis is challenging. The use of luciferase-expressing p... Read More about Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model.

The role of heparan sulfate in host macrophage infection by Leishmania species (2018)
Journal Article
Maciej-Hulme, M., Skidmore, M., & Price, H. (2018). The role of heparan sulfate in host macrophage infection by Leishmania species. Transactions, 46(4), 789-796. https://doi.org/10.1042/BST20170398

The leishmaniases are a group of neglected tropical diseases caused by parasites from the Leishmania genus. More than 20 Leishmania species are responsible for human disease, causing a broad spectrum of symptoms ranging from cutaneous lesions to a fa... Read More about The role of heparan sulfate in host macrophage infection by Leishmania species.

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. (2018)
Journal Article
Price, H., Berry, S., Hameed, H., Thomason, A., Maciej-Hulme, M., Saif Abou-Akkada, S., & Horrocks, P. (2018). Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. PLoS Neglected Tropical Diseases, 12(7), Article e0006639 . https://doi.org/10.1371/journal.pntd.0006639

The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging. New th... Read More about Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays..

Schistosoma mansoni cercarial elastase (SmCE): differences in immunogenic properties of native and recombinant forms (2017)
Journal Article
El-Faham, M., Wheatcroft-Francklow, K., Price, H., Sayers, J., & Doenhoff, M. (2017). Schistosoma mansoni cercarial elastase (SmCE): differences in immunogenic properties of native and recombinant forms. Parasitology, 144(10), 1356-1364. https://doi.org/10.1017/s0031182017000658

The Schistosoma mansoni cercarial elastase (SmCE) has previously been shown to be poorly immunogenic in mice. However, a minority of mice were able to produce antibodies against SmCE after multiple immunizations with crude preparations containing the... Read More about Schistosoma mansoni cercarial elastase (SmCE): differences in immunogenic properties of native and recombinant forms.

First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa) (2016)
Journal Article
Sangaré, I., Dabiré, R., Guiguemdé, R., Fournet, F., Price, H., Djibougou, A., …Banuls, A. (2016). First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa). Research Journal of Parasitology, 12(1), 27-32. https://doi.org/10.3923/jp.2017.27.32

Background and Objective: Human Visceral Leishmaniasis (HVL) is a systemic neglected tropical diseases and potentially lethal disease caused by infection with protozoan parasites of the Leishmania genus. In the causal, agent of HVL is L. infantum and... Read More about First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa).

Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei (2016)
Journal Article
Tate, E., Wright, M., Paape, D., Price, H., & Smith, D. (2016). Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei. ACS Infectious Diseases, 2(6), 427-441. https://doi.org/10.1021/acsinfecdis.6b00034

The enzyme N-myristoyltransferase (NMT) catalyzes the essential fatty acylation of substrate proteins with myristic acid in eukaryotes and is a validated drug target in the parasite Trypanosoma brucei, the causative agent of African trypanosomiasis (... Read More about Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei.

Imaging African trypanosomes (2013)
Journal Article
MacLean, L., Myburgh, E., Rodgers, J., & Price, H. (2013). Imaging African trypanosomes. Parasite immunology, 35(9-10), 283 -294. https://doi.org/10.1111/pim.12046

Trypanosoma brucei are extracellular kinetoplastid parasites transmitted by the blood-sucking tsetse fly. They are responsible for the fatal disease human African trypanosomiasis (HAT), also known as sleeping sickness. In late-stage infection, trypan... Read More about Imaging African trypanosomes.