All Outputs (10)

Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics (2024)
Journal Article
Nayeem Hasan, M., Khalil, I., Baker Chowdhury, M. A., Rahman, M., Asaduzzaman, M., Billah, M., …Haider, N. (in press). Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics. GreSIS - Greater South Information System, https://doi.org/10.60692/gc5zx-3tc77

The objectives of this study were to compare dengue virus (DENV) cases, deaths, case-fatality ratio [CFR], and meteorological parameters between the first and the recent decades of this century (2000-2010 vs. 2011-2022) and to describe the trends, se... Read More about Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics.

Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics (2024)
Journal Article
Nayeem Hasan, M., Khalil, I., Baker Chowdhury, M. A., Rahman, M., Asaduzzaman, M., Billah, M., …Haider, N. (in press). Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics. GreSIS - Greater South Information System, https://doi.org/10.60692/x6t6v-mbt18

The objectives of this study were to compare dengue virus (DENV) cases, deaths, case-fatality ratio [CFR], and meteorological parameters between the first and the recent decades of this century (2000-2010 vs. 2011-2022) and to describe the trends, se... Read More about Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics.

The perplexing PEXEL protein secretory pathway (2018)
Journal Article
Russo. (2018). The perplexing PEXEL protein secretory pathway. Nature Reviews Microbiology, 969 - 970. https://doi.org/10.1038/s41564-018-0235-2

Plasmodium parasites possess a unique PEXEL sorting pathway to deliver secretory proteins into the host cells in which they reside. A new study shows the existence of independent sorting/entry complexes to detect and deliver PEXEL proteins into the p... Read More about The perplexing PEXEL protein secretory pathway.

Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite (2018)
Journal Article
Russo. (2018). Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite. PLoS Pathogens, https://doi.org/10.1371/journal.ppat.1007031

Parasite egress from infected erythrocytes and invasion of new red blood cells are essential processes for the exponential asexual replication of the malaria parasite. These two tightly coordinated events take place in less than a minute and are in p... Read More about Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.

Evaluation of analogues of furan-amidines as inhibitors of NQO2 (2018)
Journal Article
Russo. (2018). Evaluation of analogues of furan-amidines as inhibitors of NQO2. Bioorganic and Medicinal Chemistry Letters, 1292 - 1297. https://doi.org/10.1016/j.bmcl.2018.03.025

Inhibitors of the enzyme NQO2 (NRH: quinone oxidoreductase 2) are of potential use in cancer chemotherapy and malaria. We have previously reported that non-symmetrical furan amidines are potent inhibitors of NQO2 and here novel analogues are evaluate... Read More about Evaluation of analogues of furan-amidines as inhibitors of NQO2.

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition (2018)
Journal Article
Russo. (2018). Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. Proceedings of the National Academy of Sciences of the United States of America, E2801 - E2810. https://doi.org/10.1073/pnas.1707929115

Owing to the prevalence of tumor-associated macrophages (TAMs) in cancer and their unique influence upon disease progression and malignancy, macrophage-targeted interventions have attracted notable attention in cancer immunotherapy. However, tractabl... Read More about Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion (2017)
Journal Article
Russo. (2017). Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion. Science, 518 - 522. https://doi.org/10.1126/science.aan1478

Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied e... Read More about Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region (2015)
Journal Article
Russo. (2015). Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region. PloS one, e0142509 - e0142509. https://doi.org/10.1371/journal.pone.0142509

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essent... Read More about Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

PfeIK1, a eukaryotic initiation factor 2a kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation (2009)
Journal Article
Russo. (2009). PfeIK1, a eukaryotic initiation factor 2a kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation. Malaria Journal, 99 - 99. https://doi.org/10.1186/1475-2875-8-99

Background: Post-transcriptional control of gene expression is suspected to play an important role in malaria parasites. In yeast and metazoans, part of the stress response is mediated through phosphorylation of eukaryotic translation initiation fact... Read More about PfeIK1, a eukaryotic initiation factor 2a kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation.

Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus (2009)
Journal Article
Russo. (2009). Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus. Molecular Microbiology, 229 - 245. https://doi.org/10.1111/j.1365-2958.2009.06639.x

The Plasmodium falciparum genome encodes a single calpain. By generating P. falciparum clones expressing C-terminally tagged calpain, we localized this protein to the nucleolus. Pf_calpain possesses an unusual and long N-terminal domain in which we i... Read More about Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus.