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Bayesian inference for joint modelling of longitudinal continuous, binary and ordinal events (2016)
Journal Article
Li, Q., Pan, J., & Belcher, J. (2016). Bayesian inference for joint modelling of longitudinal continuous, binary and ordinal events. Statistical Methods in Medical Research, 25(6), https://doi.org/10.1177/0962280214526199

In medical studies, repeated measurements of continuous, binary and ordinal outcomes are routinely collected from the same patient. Instead of modelling each outcome separately, in this study we propose to jointly model the trivariate longitudinal re... Read More about Bayesian inference for joint modelling of longitudinal continuous, binary and ordinal events.

Symptom recognition and perceived urgency of help-seeking for rheumatoid arthritis and other diseases in the general public: A mixed method approach. (2016)
Journal Article
Simons, G., Belcher, J., Morton, C., Kumar, K., Falahee, M., Mallen, C. D., …Raza, K. (2017). Symptom recognition and perceived urgency of help-seeking for rheumatoid arthritis and other diseases in the general public: A mixed method approach. Arthritis Care and Research, 69(5), 633-641. https://doi.org/10.1002/acr.22979

OBJECTIVE: Clinical outcomes in rheumatoid arthritis (RA) are improved if the disease is treated early. However, treatment is often significantly delayed as a result of delayed help-seeking by patients who fail to recognise its symptoms or the need f... Read More about Symptom recognition and perceived urgency of help-seeking for rheumatoid arthritis and other diseases in the general public: A mixed method approach..

DIAGNOSTIC DELAY FOR GIANT CELL ARTERITIS (GCA). A SYSTEMATIC REVIEW AND META-ANALYSIS (2016)
Journal Article
Prior, J. A., Ranjbar, H., Belcher, J., Mackie, S., & Mallen, C. D. (2016). DIAGNOSTIC DELAY FOR GIANT CELL ARTERITIS (GCA). A SYSTEMATIC REVIEW AND META-ANALYSIS. Annals of the Rheumatic Diseases, 75(S2), 1092-1092. https://doi.org/10.1136/annrheumdis-2016-eular.2639

Background The diagnosis of giant cell arteritis (GCA) remains difficult, with patients often presenting with non-specific and atypical symptoms. Such ambiguity can lead to delays in the diagnosis of GCA, which in-turn may result in the patient exper... Read More about DIAGNOSTIC DELAY FOR GIANT CELL ARTERITIS (GCA). A SYSTEMATIC REVIEW AND META-ANALYSIS.

PATIENT PRIORITIES FOR PMR RESEARCH: A PRIMARY CARE SURVEY (2016)
Journal Article
Hider, S., Morton, C., Muller, S., Belcher, J., Gilbert, K., Bucknall, M., & Mallen, C. (2016). PATIENT PRIORITIES FOR PMR RESEARCH: A PRIMARY CARE SURVEY. Annals of the Rheumatic Diseases, 75, 169-169. https://doi.org/10.1136/annrheumdis-2016-eular.5915

Background Polymyalgia rheumatica (PMR) is a common inflammatory disorder of older (>50 years) adults, frequently managed in primary care. PMR remains under-researched despite the significant impact this condition has on patient's quality of life. Ex... Read More about PATIENT PRIORITIES FOR PMR RESEARCH: A PRIMARY CARE SURVEY.

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis (2015)
Journal Article
Gilchrist, F. J., Belcher, J., Jones, A. M., Smith, D., Smyth, A. R., Southern, K. W., …Lenney, W. (2015). Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis. ERJ Open Research, 1(2), https://doi.org/10.1183/23120541.00044-2015

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeru... Read More about Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Clustering of pain and its associations with health in people aged 50 years and older: cross-sectional results from the North Staffordshire Osteoarthritis Project (2015)
Journal Article
Lacey, R. J., Strauss, V. Y., Rathod, T., Belcher, J., Croft, P. R., Natvig, B., …McBeth, J. (2015). Clustering of pain and its associations with health in people aged 50 years and older: cross-sectional results from the North Staffordshire Osteoarthritis Project. BMJ Open, 5(11), https://doi.org/10.1136/bmjopen-2015-008389

Objective Most pain in patients aged =50 years affects multiple sites and yet the predominant mode of presentation is single-site syndromes. The aim of this study was to investigate if pain sites form clusters in this population and if any such clust... Read More about Clustering of pain and its associations with health in people aged 50 years and older: cross-sectional results from the North Staffordshire Osteoarthritis Project.

One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. (2015)
Journal Article
Rzewuska, M., Mallen, C. D., Strauss, V. Y., Belcher, J., & Peat, G. (2015). One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. Journal of Psychosomatic Research, 79(3), 195 - 201. https://doi.org/10.1016/j.jpsychores.2015.05.016

OBJECTIVE: Distinguishing transient from persistent anxiety and depression symptoms in older people presenting to general practice with musculoskeletal pain is potentially important for effective management. This study sought to identify distinct pos... Read More about One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis..

Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters (2015)
Journal Article
Patel, N., Belcher, J., Thorpe, G., Forsyth, N. R., & Spiteri, M. A. (2015). Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters. Respiratory Research, 16, Article 62. https://doi.org/10.1186/s12931-015-0219-1

BACKGROUND: Saliva is increasingly promoted as an alternative diagnostic bio-sample to blood; however its role in respiratory disease requires elucidation. Our aim was to investigate whether C-reactive protein (CRP), procalcitonin (PCT) and neutrophi... Read More about Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters.

O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink (2015)
Journal Article
Clarson, L. E., Hider, S. L., Belcher, J., Roddy, E., Heneghan, C., & Mallen, C. D. (2015). O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink. Rheumatology, 54(S1), https://doi.org/10.1093/rheumatology/kev084.001

Background: Current evidence suggests that gout is an independent risk factor for excess cardiovascular morbidity and mortality; yet, suboptimal care for patients with gout in primary care persists. We aimed to identify risk factors specific to these... Read More about O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink.

Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies (2015)
Journal Article
Mallen, Roddy, & Belcher. (2015). Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies. Arthritis Research and Therapy, 17, Article 90. https://doi.org/10.1186/s13075-015-0610-9

ntroduction To determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis. Methods Systematic review and meta-... Read More about Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies.

Pilot study on virtual imaging for patient information on radiotherapy planning and delivery (2015)
Journal Article
Sule-Suso, J., Finney, S., Bisson, J., Hammersley, S., Jassel, S., Knight, R., …Moloney, A. (2015). Pilot study on virtual imaging for patient information on radiotherapy planning and delivery. Radiography, 273-277. https://doi.org/10.1016/j.radi.2015.02.002

It is widely accepted that health professionals might sometimes underestimate cancer patients' needs for information on the complex process of radiotherapy (RT) planning and delivery. Furthermore, relatives might also feel excluded from the treatment... Read More about Pilot study on virtual imaging for patient information on radiotherapy planning and delivery.

Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis (2015)
Journal Article
Roddy, Mallen, Belcher, Clarson, & Hider. (2015). Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis. European Journal of Preventive Cardiology, 22(3), 335 -343. https://doi.org/10.1177/2047487313514895

BACKGROUND: Hyperuricaemia, the biochemical precursor to gout, has been shown to be an independent risk factor for mortality from cardiovascular disease (CVD), although studies examining the clinical phenomenon of gout and risk of CVD mortality repor... Read More about Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis.

Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink (2015)
Journal Article
Roddy, Mallen, Belcher, & Hider. (2015). Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink. Annals of the Rheumatic Diseases, 642 - 647. https://doi.org/10.1136/annrheumdis-2014-206432

OBJECTIVES: To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studi... Read More about Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink.

EVALUATION OF SALIVA BIOMARKERS AS INDICATORS OF HEALTH STATUS AND EXACERBATIONS IN COPD (2014)
Journal Article
Patel, N., Jones, P., Adamson, V., Thorpe, G., Belcher, J., & Spiteri, M. (2014). EVALUATION OF SALIVA BIOMARKERS AS INDICATORS OF HEALTH STATUS AND EXACERBATIONS IN COPD. Thorax, 69(S2), A102-A103. https://doi.org/10.1136/thoraxjnl-2014-206260.205

Saliva is increasingly promoted as a suitable alternative diagnostic bio-sample to blood, yet its role in respiratory disease is still to be elucidated. Salivary levels of C-Reactive Protein (CRP), Procalcitonin (PCT) and Neutrophil Elastase (NE)... Read More about EVALUATION OF SALIVA BIOMARKERS AS INDICATORS OF HEALTH STATUS AND EXACERBATIONS IN COPD.

Risk of vascular events in patients with polymyalgia rheumatica. (2014)
Journal Article
Hancock, A. T., Mallen, C. D., Muller, S., Belcher, J., Roddy, E., Helliwell, T., & Hider, S. L. (2014). Risk of vascular events in patients with polymyalgia rheumatica. Canadian Medical Association Journal, 186(13), E495 - E501. https://doi.org/10.1503/cmaj.140266

BACKGROUND: Polymyalgia rheumatica is one of the most common inflammatory rheumatologic conditions in older adults. Other inflammatory rheumatologic disorders are associated with an excess risk of vascular disease. We investigated whether polymyalgia... Read More about Risk of vascular events in patients with polymyalgia rheumatica..

Developing Objective Metrics for Unit Staffing (DOMUS) study (2014)
Journal Article
Siddiqui, I., Whittingham, B., Meadowcroft, K., Richardson, M., Cooper, J. C., Belcher, J., …Ismail, K. M. K. (2014). Developing Objective Metrics for Unit Staffing (DOMUS) study. BMJ Open, 4(9), Article ARTN e005398. https://doi.org/10.1136/bmjopen-2014-005398

Objective Safe midwifery staffing levels on delivery suites is a priority area for any maternity service. Escalation policies are tools that provide an operational response to emergency pressures. The aim of this study was to assess the feasibility o... Read More about Developing Objective Metrics for Unit Staffing (DOMUS) study.

Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink (2014)
Journal Article
Clarson, L. E., Hider, S. L., Belcher, J., Heneghan, C., Roddy, E., & Mallen, C. D. (2014). Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 74(4), 642-647. https://doi.org/10.1136/annrheumdis-2014-205252

Objectives To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studie... Read More about Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink.