All Outputs (92)

A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications (2023)
Journal Article

The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most widely reported Good Manufacturing Practice–compliant bioreactor used for the expansion of adherent cell populations, both for research purposes and cl... Read More about A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications.

Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report (2023)
Journal Article

There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial... Read More about Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.

AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA (2023)
Conference Proceeding

The objectives of the study were to investigate demographic, injury and surgery/treatment-associated factors that could influence clinical outcome, following Autologous Chondrocyte Implantation (ACI) in a large, “real-world”, 20 year longitudinally c... Read More about AUTOLOGOUS CHONDROCYTE IMPLANTATION: MULTILEVEL MODELLING OF 20-YEAR LONGITUDINAL OUTCOME DATA.

PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA (2023)
Journal Article

Stratification is required to ensure that only those patients likely to benefit, receive Autologous Chondrocyte Implantation (ACI); ideally by assessing a biomarker in the blood. This study aimed to assess differences in the plasma proteome of indivi... Read More about PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA.

Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. (2023)
Journal Article

BACKGROUND: Stratification is required to ensure that only patients likely to benefit receive autologous chondrocyte implantation (ACI). It would be advantageous to identify biomarkers to predict ACI outcome that are measurable in blood, avoiding the... Read More about Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening..

Umbilical Cord MSC Treated Osteoarthritic Sheep Display Reduced Radiographic Changes: Proteomic Biomarker Profiling of Synovial Fluids Implicate an Immunomodulatory Mechanism (2023)
Presentation / Conference

Comparative analysis of umbilical cord mesenchymal stromal cells versus their extracellular vesicles for the treatment of inflammatory arthritis (2023)
Presentation / Conference

Up-scale Manufacture of Chondrocytes from Adult and Juvenile Cartilage Donors for Allogeneic Chondrocyte Therapies (2023)
Journal Article

Commonality Between The Proteome Signatures Of Clinical Response To Surgically Sustained And Acute Traumatic Cartilage Injuries In Two Human Knee Cohorts (2023)
Journal Article

Chondrocyte Isolation and Expansion (2022)
Book Chapter

Chondrocyte isolation requires a combination of enzymatic and mechanical digestion of cartilaginous tissues in order to release the chondrocytes. Extracted primary chondrocytes will then adhere to standard tissue culture plastics, typically in small... Read More about Chondrocyte Isolation and Expansion.

A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2022)
Journal Article

1Abstract1.1IntroductionSpinal Cord Injury (SCI) is a major cause of disability, with complications post-injury often leading to life-long health issues with need of extensive treatment. Neurological outcome post-SCI can be variable and difficult to... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

CHONDROCYTES FROM TWO JUVENILE DONOR SOURCES (POLYDACTYLY DIGITS AND ILIAC APOPHYSIS) CAN BE UP-SCALE EXPANDED IN THE QUANTUM® BIOREACTOR (2022)
Conference Proceeding

Assessing allogeneic chondroprogenitor manufacture in xeno-free and serum-free media (2022)
Presentation / Conference

Altered Acute Phase Response Signalling following Cartilage Harvest Can be Identified in the Plasma of 'Non-responder' Patients to Autologous Chondrocyte Implantation (2022)
Dataset

Investigation of the blood proteome in response to spinal cord injury in rodent models (2021)
Journal Article

STUDY DESIGN: Explanatory and Mechanistic Study OBJECTIVES: A better understanding of the ‘whole-body’ response following spinal cord injury (SCI) is needed to guide future research aimed at developing novel therapeutic interventions and identifying... Read More about Investigation of the blood proteome in response to spinal cord injury in rodent models.

Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. (2021)
Journal Article

Human umbilical cord (hUC)- or bone marrow (hBM)-derived mesenchymal stromal cells (MSCs) were evaluated as an allogeneic source of cells for cartilage repair. We aimed to determine if they could enhance healing of chondral defects with or without th... Read More about Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model..

An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. (2021)
Journal Article

Chondrocyte-based cartilage repair strategies, such as articular chondrocyte implantation, are widely used, but few studies addressed the communication between native subchondral bone cells and the transplanted chondrocytes. An indirect co-culture mo... Read More about An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans..

The Management of Talar Osteochondral Lesions - Current Concepts (2021)
Journal Article

Osteochondral lesions of the talus (OLTs) are a common complication following trauma, involving both the articular cartilage and the underlying subchondral bone, with variable aetiologies and often presenting with non-specific symptoms. Diagnosis of... Read More about The Management of Talar Osteochondral Lesions - Current Concepts.

Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy (2021)
Journal Article

Background: Biomarkers are needed to predict clinical outcomes for microfracture and osteotomy surgeries to ensure patients can be better stratified to receive the most appropriate treatment. Purpose: To identify novel biomarker candidates and to... Read More about Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy.

Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy (2021)
Journal Article

Objectives The ability to predict which patients will improve following routine surgeries aimed at preventing the progression of osteoarthritis is needed to aid patients being stratified to receive the most appropriate treatment. This study aimed to... Read More about Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy.