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ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study (2021)
Journal Article
Mamas, & Mallen. (2021). ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keab234

OBJECTIVES: To examine the association between ß-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain. METHODS: Data source: Clinical Practice Research Datalink. Participants aged =40?y... Read More about ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.

Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study (2021)
Journal Article
Mamas. (2021). Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study

Background and Purpose Whilst cancer is a risk factor for acute ischaemic stroke (AIS), its impact on AIS prognosis between metastatic and non-metastatic (MC and NMC) disease is poorly understood. Furthermore, the receipt of intravenous thrombolysis... Read More about Prognosis of Acute Ischaemic Stroke in Cancer Patients: A National Inpatient Sample Study.

Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic (2021)
Journal Article
Rashid, & Mamas. (2021). Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic. Heart, 734-740. https://doi.org/10.1136/heartjnl-2020-318356

Objective: There are concerns that health care and outcomes of BAME communities are disproportionately impacted by the COVID19 pandemic. We investigated admission rates, treatment and mortality of Black, Asian and Minority Ethnic (BAME) with acute my... Read More about Racial differences in management and outcomes of acute myocardial infarction during COVID19 pandemic.

Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA. (2021)
Journal Article
Mamas. (2021). Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA. https://doi.org/10.1093/eurheartj/ehaa1032

AIMS: The post-discharge outcomes of patients with cancer who undergo PCI are not well understood. This study evaluates the rates of readmissions within 90?days for acute myocardial infarction (AMI) and bleeding among patients with cancer who undergo... Read More about Percutaneous coronary intervention in patients with cancer and readmissions within 90 days for acute myocardial infarction and bleeding in the USA..

Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis (2021)
Journal Article
Gelbenegger, G., Schoergenhofer, C., Jilma, B., Gager, G. M., Dizdarevic, A. M., Mamas, M. A., …Siller‐Matula, J. M. (2021). Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis. Clinical Pharmacology and Therapeutics, 110(2), 424-431. https://doi.org/10.1002/cpt.2226

Dual antiplatelet therapy (DAPT) and subsequent P2Y12 inhibitor monotherapy, particularly ticagrelor, is an emerging treatment strategy in patients undergoing percutaneous coronary intervention (PCI). This meta-analysis was designed to investigate wh... Read More about Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis.

Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. (2021)
Journal Article
Mamas. (2021). Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. https://doi.org/10.1007/s11886-021-01453-y

PURPOSE OF REVIEW: This article reviews the evidence on optimal medical therapy (OMT) versus coronary revascularization in patients with stable ischemic heart disease (SIHD) and advanced chronic kidney disease (CKD). RECENT FINDINGS: A post hoc analy... Read More about Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease..

Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease (2021)
Journal Article
Paul, T. K., Mamas, M. A., Shanmugasundaram, M., Nagarajarao, H. S., Ojha, C. P., Jneid, H., …White, C. J. (2021). Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease. Current Cardiology Reports, 23(4), https://doi.org/10.1007/s11886-021-01453-y

Purpose of Review This article reviews the evidence on optimal medical therapy (OMT) versus coronary revascularization in patients with stable ischemic heart disease (SIHD) and advanced chronic kidney disease (CKD). Recent Findings A post hoc an... Read More about Medical Therapy Versus Revascularization in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease.

Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample (2021)
Journal Article
Ullah, W., Al-Khadra, Y., Mir, T., Darmoch, F., Pacha, H. M., Sattar, Y., …Alraies, M. C. (2021). Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample. Journal of Cardiovascular Medicine, 22(7), 586 - 593. https://doi.org/10.2459/JCM.0000000000001172

AIM: We sought to determine the racial and ethnical disparities in the delivery of TAVR and to evaluate the in-hospital outcomes and utilization of TAVR stratified by patient ethnicity. METHOD: Using a national inpatient sample database between 2011... Read More about Temporal trends in utilization and outcomes of transcatheter aortic valve replacement in different races: an analysis of the national inpatient sample.

Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies (2021)
Journal Article
Huang, X., Wilkie, R., Mamas, M., & Yu, D. (2021). Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies. MedRxiv, https://doi.org/10.1101/2021.02.14.21251130v1

Background People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities f... Read More about Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies.

Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database). (2021)
Journal Article
Mamas, Sykes, R., Mohamed, M. O., Kwok, C. S., Mamas, M. A., & Berry, C. (2021). Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database). Clinical Cardiology, 44(3), 291 - 306. https://doi.org/10.1002/clc.23543

Percutaneous coronary intervention (PCI) improves anginal chest pain in most, but not all, treated patients. PCI is associated with unplanned readmission for angina and non-specific chest pain within 30-days of index PCI. Patients with an index hospi... Read More about Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database)..

Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020 (2021)
Journal Article
Wu, J., Mafham, M., Mamas, M. A., Rashid, M., Kontopantelis, E., Dean, J. E., …Gale, C. P. (2021). Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020. Mayo Clinic Proceedings, 96(4), 952 - 963. https://doi.org/10.1016/j.mayocp.2021.02.007

OBJECTIVE: To describe the place and cause of death during the coronavirus disease 2019 (COVID-19) pandemic to assess its impact on excess mortality. METHODS: This national death registry included all adult (aged =18 years) deaths in England and... Read More about Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020.

Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2020.11.016

Transradial access (TRA) has emerged as an alternative to transfemoral access (TFA) for percutaneous coronary intervention (PCI) in ST elevation myocardial infarction (STEMI) patients. However, the rate of TRA adoption has been much slower in the acu... Read More about Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction..

Excess mortality in England and Wales during the first wave of the COVID-19 pandemic (2021)
Journal Article
Mamas. (2021). Excess mortality in England and Wales during the first wave of the COVID-19 pandemic. Journal of epidemiology and community health, 213-223. https://doi.org/10.1136/jech-2020-214764

Background Deaths during the COVID-19 pandemic result directly from infection and exacerbation of other diseases and indirectly from deferment of care for other conditions, and are socially and geographically patterned. We quantified excess mortality... Read More about Excess mortality in England and Wales during the first wave of the COVID-19 pandemic.

Estimating the population health burden of musculoskeletal conditions using primary care electronic health records (2021)
Journal Article
Yu, D., Peat, G., Jordan, K., Bailey, J., Prieto-Alhambra, D., Robinson, D., …Wilkie, R. (2021). Estimating the population health burden of musculoskeletal conditions using primary care electronic health records. Rheumatology, 60(10), 4832-4843. https://doi.org/10.1093/rheumatology/keab109

Objectives Better indicators from affordable, sustainable data sources are needed to monitor population burden of musculoskeletal conditions. We propose five indicators of musculoskeletal health and assessed if routinely available primary care elect... Read More about Estimating the population health burden of musculoskeletal conditions using primary care electronic health records.

Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database. (2021)
Journal Article
Kinnaird, T., Anderson, R., Gallagher, S., Sharp, A. S. P., Farooq, V., Ludman, P., …Mamas, M. (2021). Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database. Catheterization and Cardiovascular Interventions, 98(1), E53-E61. https://doi.org/10.1002/ccd.29549

INTRODUCTION: The impact of a vascular complication (VC) in the setting of intraaortic balloon pump (IABP) supported PCI on clinical outcomes is unclear. METHODS: Using data from the BCIS National PCI Database, multivariate logistic regression was us... Read More about Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database..

The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial. (2021)
Journal Article
Mamas. (2021). The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial. European Heart Journal, 684-696. https://doi.org/10.1093/eurheartj/ehaa758

Importance: Cardiovascular accumulation of collagen (fibrosis) may contribute to the progression from ventricular dysfunction to heart failure. Galectin-3, a potential marker of pro-fibrotic activity, might identify those at greater risk. Objective:... Read More about The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial..

Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis (2021)
Journal Article
Mamas. (2021). Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis. European Heart Journal: Acute Cardiovascular Care, 829-839. https://doi.org/10.1093/ehjacc/zuaa032

Aims Primary percutaneous coronary intervention (pPCI) is the gold standard, guideline-recommended revascularization strategy in patients presenting with ST-elevation myocardial infarction (STEMI). However, there are limited data on its use and effe... Read More about Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis.