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Investigating Heterogeneity of Effects and Associations Using Interaction Terms (2018)
Journal Article
Mamas. (2018). Investigating Heterogeneity of Effects and Associations Using Interaction Terms. Journal of Clinical Epidemiology, 79-83. https://doi.org/10.1016/j.jclinepi.2017.09.012

Effect heterogeneity, the variability of an association or exposure across subgroups, usually warrants further investigation. The aim of this deeper analysis is to identify effect modifiers (or moderators) and quantify their relationship with the exp... Read More about Investigating Heterogeneity of Effects and Associations Using Interaction Terms.

Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study (2017)
Journal Article
Mamas. (2017). Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study. Journal of epidemiology and community health, 140-147. https://doi.org/10.1136/jech-2017-209999

Background: Socio-economic deprivation is a key determinant for health. In England, the Index of Multiple Deprivation (IMD) is a widely used composite measure of deprivation. However, little is known about its spatial clustering or persistence acros... Read More about Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study.

Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register (2017)
Journal Article
Mamas. (2017). Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register. Journal of the Neurological Sciences, 26-30. https://doi.org/10.1016/j.jns.2017.09.047

AbstractBackground Previous research has demonstrated an association between anaemia and poor outcomes in acute stroke. This study aimed to assess the impact of anaemia on stroke by anaemia subtype. Methods Data from a prospective UK Regional Stroke... Read More about Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register.

A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation (2017)
Journal Article
Mamas. (2017). A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation. Heart, 1109-1116. https://doi.org/10.1136/heartjnl-2017-312489

Objective Existing clinical prediction models (CPM) for short-term mortality after transcatheter aortic valve implantation (TAVI) have limited applicability in the UK due to moderate predictive performance and inconsistent recording practices across... Read More about A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation.

Longitudinal deformation bench testing using a coronary artery model: a new standard? (2017)
Journal Article
Mamas. (2017). Longitudinal deformation bench testing using a coronary artery model: a new standard?. Open Heart, https://doi.org/10.1136/openhrt-2016-00053

Objectives To compare susceptibility of five different stent platforms with longitudinal stent deformation (LSD) using a clinically relevant bench testing model simulating both short and long malapposed lengths. Background Recent data suggest that de... Read More about Longitudinal deformation bench testing using a coronary artery model: a new standard?.

Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide (2017)
Journal Article
Mamas. (2017). Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide. FEBS Open Bio, 1672 -1685. https://doi.org/10.1002/2211-5463.12284

Advanced glycation end products (AGE) are central to the development of cardiovascular complications associated with diabetes mellitus. AGE may alter cellular function through cross-linking of cellular proteins or by activating the AGE receptor (RAGE... Read More about Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide.

Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry (2017)
Journal Article
Mamas. (2017). Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry. JACC. Cardiovascular interventions, 2040-2047. https://doi.org/10.1016/j.jcin.2017.05.020

Objectives This study sought to determine the risk factors for post-transcatheter aortic valve replacement (TAVR) dialysis and to determine the impact of pre-TAVR or post-TAVR dialysis on mortality. Background TAVR is now established as an alter... Read More about Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry.

Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population? (2017)
Journal Article
Mamas. (2017). Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population?. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.117.007229

Background Transcatheter aortic valve implantation (TAVI) is indicated for patients with aortic stenosis who are intermediate-high surgical risk. Although all-cause mortality rates after TAVI are established, survival attributable to the procedure i... Read More about Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population?.

Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres. (2017)
Journal Article
Mamas. (2017). Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres. BMJ Open, e016866 - ?. https://doi.org/10.1136/bmjopen-2017-016866

OBJECTIVES: The effect of weekend versus weekday admission following acute coronary syndrome (ACS) on process of care and mortality remains controversial. This study aimed to investigate the 'weekend-effect' on outcomes using a multicentre dataset of... Read More about Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres..

Early Readmissions After Acute Myocardial Infarction (2017)
Journal Article
Mamas, Kwok, C. S., Wong, C. W., Shufflebotham, H., Brindley, L., Fatima, T., …Mamas, M. A. (2017). Early Readmissions After Acute Myocardial Infarction. American Journal of Cardiology, 120(5), 723-728. https://doi.org/10.1016/j.amjcard.2017.05.049

This study aims to evaluate the rate, predictors, and causes of 30-day readmissions in a single tertiary hospital in the United Kingdom. We conducted a retrospective study of all patients admitted between 2012 and 2014 with a diagnosis of acute myoca... Read More about Early Readmissions After Acute Myocardial Infarction.

Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review (2017)
Journal Article
Mamas. (2017). Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review. Heart, 1315-1322. https://doi.org/10.1136/heartjnl-2016-310852

Background: Subcutaneous implantable cardioverter defibrillators (S-ICD) are an alternative to conventional transvenous implantable cardioverter defibrillators (TV-ICD) in patients not requiring pacing. We sought to define the efficacy and safety of... Read More about Efficacy And Safety Of The Subcutaneous Implantable Cardioverter Defibrillator: A Systematic Review.

The relationship of body mass index to percutaneous coronary intervention outcomes: Does the obesity paradox exist in contemporary PCI cohorts? Insights from the British Cardiovascular Intervention Society registry. (2017)
Journal Article
Mamas. (2017). The relationship of body mass index to percutaneous coronary intervention outcomes: Does the obesity paradox exist in contemporary PCI cohorts? Insights from the British Cardiovascular Intervention Society registry. JACC. Cardiovascular interventions, 1283-1292. https://doi.org/10.1016/j.jcin.2017.03.013

Objectives The aims of this study were to examine the relationship between body mass index (BMI) and clinical outcomes following percutaneous coronary intervention (PCI) and to determine the relevance of different clinical presentations requiring PC... Read More about The relationship of body mass index to percutaneous coronary intervention outcomes: Does the obesity paradox exist in contemporary PCI cohorts? Insights from the British Cardiovascular Intervention Society registry..

Transcatheter Aortic Valve Implantation With or Without Percutaneous Coronary Artery Revascularization Strategy: A Systematic Review and Meta-analysis (2017)
Journal Article
Mamas. (2017). Transcatheter Aortic Valve Implantation With or Without Percutaneous Coronary Artery Revascularization Strategy: A Systematic Review and Meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.117.005960

Background Recent recommendations suggest that in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation and coexistent significant coronary artery disease, the latter should be treated before the index procedure; ho... Read More about Transcatheter Aortic Valve Implantation With or Without Percutaneous Coronary Artery Revascularization Strategy: A Systematic Review and Meta-analysis.

Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus. (2017)
Journal Article
Mamas, M., & Rashid, M. (2017). Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus. Catheterization and Cardiovascular Interventions, 1195-1204. https://doi.org/10.1002/ccd.26882

OBJECTIVES: To assess the mortality in patients with diabetes mellitus (DM) following percutaneous coronary intervention (PCI) according to their insulin requirement and PCI setting (elective, urgent, and emergency). BACKGROUND: DM is a major risk fa... Read More about Mortality after percutaneous coronary revascularization: Prior cardiovascular risk factor control and improved outcomes in patients with diabetes mellitus..

Do patients have a worse outcome with heart failure than cancer? A primary care based cohort study with 10-year follow-up in Scotland (2017)
Journal Article
Mamas. (2017). Do patients have a worse outcome with heart failure than cancer? A primary care based cohort study with 10-year follow-up in Scotland. European Journal of Heart Failure, 1095-1104. https://doi.org/10.1002/ejhf.822

Aims This study was designed to evaluate whether survival rates in patients with heart failure (HF) are better than those in patients with diagnoses of the four most common cancers in men and women, respectively, in a contemporary primary care cohor... Read More about Do patients have a worse outcome with heart failure than cancer? A primary care based cohort study with 10-year follow-up in Scotland.

Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis (2017)
Journal Article
Mamas. (2017). Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis. Stroke, 1306-1315. https://doi.org/10.1161/strokeaha.116.015915

Background and Purpose—Silent ischemic embolic lesions are common after transcatheter aortic valve implantation (TAVI). The use of embolic protection devices (EPD) may reduce the occurrence of these embolic lesions. Thus, a quantitative overview and... Read More about Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis.

Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts. (2017)
Journal Article
Mamas. (2017). Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.116.004457

BACKGROUND: There are limited data on comparison of contemporary drug-eluting stent (DES) platforms, previous generation DES, and bare-metal stents (BMS) for percutaneous coronary intervention in saphenous vein grafts (SVG). We aimed to assess clinic... Read More about Choice of Stent for Percutaneous Coronary Intervention of Saphenous Vein Grafts..

Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis (2017)
Journal Article
Rashid, & Mamas. (2017). Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis. International Journal of Cardiology, 145-153. https://doi.org/10.1016/j.ijcard.2017.04.037

Background Aortic stenosis (AS) poses a perioperative management dilemma to physicians looking after patients who require non-cardiac surgery. The objective of this review is to investigate mortality and adverse cardiovascular events in patients wit... Read More about Aortic Stenosis and Non-Cardiac Surgery: A Systematic Review and Meta-Analysis.

Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database (2017)
Journal Article
Mamas, M., & Nolan, J. (2017). Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database. JACC: Cardiovascular Interventions, 635-644. https://doi.org/10.1016/j.jcin.2016.11.055

Objectives The aim of this study was to assess, using a national percutaneous coronary intervention (PCI) database, access-site choice and outcomes after chronic total occlusion (CTO) PCI. Background Given the influence of access site on outcome... Read More about Vascular access site and outcomes among 26,807 chronic total coronary occlusion angioplasty cases from the British Cardiovascular Interventions Society National database.