All Outputs (164)

Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019 (2022)
Journal Article
Wei, S., Miranda, J. J., Mamas, M. A., Zühlke, L. J., Kontopantelis, E., Thabane, L., & Van Spall, H. G. C. (2023). Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019. European Heart Journal - Quality of Care and Clinical Outcomes, 9(7), 662-672. https://doi.org/10.1093/ehjqcco/qcac088

Background Heart failure (HF) is a global epidemic. Objective To assess global sex differences in HF epidemiology across country income levels. Methods and results Using Global Burden of Disease (GBD) data from 204 countries and territories 1990–2019... Read More about Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019.

Phenotyping for percutaneous coronary intervention and long-term recurrent weighted outcomes (2022)
Journal Article
Mamas. (2022). Phenotyping for percutaneous coronary intervention and long-term recurrent weighted outcomes. International Journal of Cardiology, 374, 12 - 19. https://doi.org/10.1016/j.ijcard.2022.12.035

Introduction Percutaneous coronary interventions (PCI) are often performed in multimorbid patients with heterogeneous characteristics and variable clinical outcomes. We aimed to identify distinct clinical phenotypes utilizing machine learning and exp... Read More about Phenotyping for percutaneous coronary intervention and long-term recurrent weighted outcomes.

Social Deprivation and Post-TAVR Outcomes in Ontario, Canada: A Population-Based Study. (2022)
Journal Article
Patel, R. V., Ravindran, M., Qiu, F., Manoragavan, R., Sud, M., Tam, D. Y., …Wijeysundera, H. C. (2023). Social Deprivation and Post-TAVR Outcomes in Ontario, Canada: A Population-Based Study. Journal of the American Heart Association, 12(1), Article e028144. https://doi.org/10.1161/JAHA.122.028144

Background Transcatheter aortic valve replacement (TAVR)/intervention has become the standard of care for treatment of severe aortic stenosis across the spectrum of risk. There are socioeconomic disparities in access to TAVR. The impact of these disp... Read More about Social Deprivation and Post-TAVR Outcomes in Ontario, Canada: A Population-Based Study..

Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry (2022)
Journal Article
Mamas. (2022). Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry. European Heart Journal, 5020-5032. https://doi.org/10.1093/eurheartj/ehac511

Background and Aims Postinfarction ventricular septal defect (PIVSD) is a mechanical complication of myocardial infarction (MI) with a poor prognosis. Surgical repair is the mainstay of treatment, although percutaneous closure is increasingly underta... Read More about Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry.

Sex differences in clinical profile and outcome after percutaneous coronary intervention for chronic total occlusion. (2022)
Journal Article
Mamas, & Rashid. (2022). Sex differences in clinical profile and outcome after percutaneous coronary intervention for chronic total occlusion. Cardiovascular Revascularization Medicine, 49, 34-41. https://doi.org/10.1016/j.carrev.2022.12.005

BACKGROUND: There are limited data around sex differences in the risk profile, treatments and outcomes of percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) lesions in contemporary interventional practice. We investigated the i... Read More about Sex differences in clinical profile and outcome after percutaneous coronary intervention for chronic total occlusion..

Temporal trends of hospitalizations, comorbidity burden and in-hospital outcomes in patients admitted with asthma in the United States: Population-based study. (2022)
Journal Article
Mamas. (2022). Temporal trends of hospitalizations, comorbidity burden and in-hospital outcomes in patients admitted with asthma in the United States: Population-based study. PloS one, e0276731 - ?. https://doi.org/10.1371/journal.pone.0276731

BACKGROUND: Asthma is a prevalent chronic respiratory condition and remains a common cause for hospitalization. However, contemporary data on asthma hospitalization rates, comorbidity burden, and in-hospital outcomes are lacking. METHODS: Survey-... Read More about Temporal trends of hospitalizations, comorbidity burden and in-hospital outcomes in patients admitted with asthma in the United States: Population-based study..

Aortic valve treatment: from the first aortic valve replacement to the last decade of revolution (2022)
Journal Article
Paradies, V., & Mamas, M. A. (2022). Aortic valve treatment: from the first aortic valve replacement to the last decade of revolution. Heart, heartjnl-2022-321933. https://doi.org/10.1136/heartjnl-2022-321933

The first aortic valve replacement (AVR) from a human patient performed in 1962 marked the beginning of an evidence-based journey of open-heart surgery for aortic valve stenosis (AVS). Surgical aortic valve replacement (SAVR) has long been the standa... Read More about Aortic valve treatment: from the first aortic valve replacement to the last decade of revolution.

Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes (2022)
Journal Article
Mamas. (2022). Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes. Scientific reports, https://doi.org/10.1038/s41598-022-04929-1

AbstractMitochondrial dysfunction is a feature of type I and type II diabetes, but there is a lack of consistency between reports and links to disease development. We aimed to investigate if mitochondrial structure–function remodelling occurs in the... Read More about Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes.

Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis. (2022)
Journal Article
Mamas, & Rashid. (2022). Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis. https://doi.org/10.1016/j.ijcha.2022.101135

Background: Individuals who present with STEMI without the standard cardiovascular risk factors (SMuRFs) of diabetes, hypercholesterolemia, hypertension, and smoking, coined SMuRF-less are not uncommon. Little is known about their outcomes as a cohor... Read More about Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis..

Comparison of Transfemoral versus Transsubclavian/Transaxillary access for transcatheter aortic valve replacement: A systematic review and meta-analysis (2022)
Journal Article
Mamas. (2022). Comparison of Transfemoral versus Transsubclavian/Transaxillary access for transcatheter aortic valve replacement: A systematic review and meta-analysis. https://doi.org/10.1016/j.ijcha.2022.101156

Femoral access is the gold standard for transcatheter aortic valve replacement (TAVR). Safe alternative access, that represents about 15 % of TAVR cases, remains important for patients without adequate transfemoral access. We aimed to perform a syste... Read More about Comparison of Transfemoral versus Transsubclavian/Transaxillary access for transcatheter aortic valve replacement: A systematic review and meta-analysis.

Has the first year of the COVID-19 pandemic reversed the trends in CV mortality between 1999-2019 in the United States? (2022)
Journal Article
Mamas. (2022). Has the first year of the COVID-19 pandemic reversed the trends in CV mortality between 1999-2019 in the United States?. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcac080

Aims Although cardiovascular (CV) mortality increased during the COVID-19 pandemic, little is known about how these patterns varied across key subgroups, include age, sex, and race and ethnicity, as well as by specific cause of CV death. Methods... Read More about Has the first year of the COVID-19 pandemic reversed the trends in CV mortality between 1999-2019 in the United States?.

Invasive Management and In-Hospital Outcomes of Myocardial Infarction Patients in United States Safety-Net Hospitals. (2022)
Journal Article
Mamas. (2022). Invasive Management and In-Hospital Outcomes of Myocardial Infarction Patients in United States Safety-Net Hospitals. Cardiovascular Revascularization Medicine, 49, 7 - 12. https://doi.org/10.1016/j.carrev.2022.11.006

AIM: Safety-net hospitals (SNHs) look after a higher proportion of uninsured patients and are often located in deprived areas. This study aimed to determine whether there are differences in the clinical characteristics, treatments and outcomes of pat... Read More about Invasive Management and In-Hospital Outcomes of Myocardial Infarction Patients in United States Safety-Net Hospitals..

Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. (2022)
Journal Article
Wright, F. L., Cheema, K., Goldacre, R., Hall, N., Herz, N., Islam, N., …Banerjee, A. (2023). Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. European Heart Journal - Quality of Care and Clinical Outcomes, 9(4), 377-388. https://doi.org/10.1093/ehjqcco/qcac077

Background Although morbidity and mortality from COVID-19 have been widely reported, the indirect effects of the pandemic beyond 2020 on other major diseases and health service activity have not been well described. Methods and results Analyses... Read More about Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries..

Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States. (2022)
Journal Article
Rashid, & Mamas. (2022). Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States. Journal of Palliative Care, 8258597221136733 - ?. https://doi.org/10.1177/08258597221136733

Objective: Limited data exist around the receipt of palliative care (PC) in patients hospitalized with common chronic conditions. We studied the independent predictors, temporal trends in rates of PC utilization in patients hospitalized with acute ex... Read More about Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States..

Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort. (2022)
Journal Article
Mamas. (2022). Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort. Mayo Clinic Proceedings, 98(4), 569-578. https://doi.org/10.1016/j.mayocp.2022.08.018

OBJECTIVE: To examine the predictors, treatments, and outcomes of the use of palliative care in patients hospitalized with acute myocardial infarction (AMI) who had a do-not-resuscitate (DNR) order. PATIENTS AND METHODS: Using the National (Natio... Read More about Palliative Care Use in Patients With Acute Myocardial Infarction and Do-Not-Resuscitate Status From a Nationwide Inpatient Cohort..

Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study) (2022)
Journal Article
Mamas. (2022). Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study). American Journal of Cardiology, 186, 71 - 79. https://doi.org/10.1016/j.amjcard.2022.10.023

Female gender has been shown to be associated with worse clinical outcomes after percutaneous coronary intervention (PCI). However, the impact of gender on the clinical outcomes of complex PCI is still poorly understood. This study examined the diffe... Read More about Impact of Sex on Clinical Outcomes in Patients undergoing Complex Percutaneous Coronary Angioplasty (from the e-ULTIMASTER Study).

The relationship between nutritional status at the time of stroke on adverse outcomes: a systematic review and meta-analysis of prospective cohort studies. (2022)
Journal Article
Mamas, M. (2022). The relationship between nutritional status at the time of stroke on adverse outcomes: a systematic review and meta-analysis of prospective cohort studies. Nutrition Reviews, 2275 - 2287. https://doi.org/10.1093/nutrit/nuac034

CONTEXT AND OBJECTIVE: The impact of existing malnutrition on stroke outcomes is poorly recognised and treated. Evidence was systematically reviewed and quantified by meta-analysis. METHODS: MEDLINE, EMBASE and Web of Science were searched from incep... Read More about The relationship between nutritional status at the time of stroke on adverse outcomes: a systematic review and meta-analysis of prospective cohort studies..

Impact of QRS Duration on Non–ST-Segment Elevation Myocardial Infarction (from a National Registry) (2022)
Journal Article
Mamas. (2022). Impact of QRS Duration on Non–ST-Segment Elevation Myocardial Infarction (from a National Registry). American Journal of Cardiology, 1 - 7. https://doi.org/10.1016/j.amjcard.2022.07.039

QRS duration (QRSd) is ill-defined and under-researched as a prognosticator in patients with non–ST-segment myocardial infarction (NSTEMI). We analyzed 240,866 adult (=18 years) hospitalizations with non–ST-segment elevation myocardial infarction usi... Read More about Impact of QRS Duration on Non–ST-Segment Elevation Myocardial Infarction (from a National Registry).

Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes (2022)
Journal Article
Mamas. (2022). Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes. Diabetes Care, 2737-2745. https://doi.org/10.2337/dc22-0894

OBJECTIVE Heart failure (HF) often develops in patients with diabetes and is recognized for its role in increased cardiovascular morbidity and mortality in this population. Most existing models predict risk in patients with prevalent rather than i... Read More about Derivation and External Validation of a Clinical Model to Predict Heart Failure Onset in Patients with Incident Diabetes.

Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials. (2022)
Journal Article
Elbadawi, A., Sedhom, R., Gad, M., Hamed, M., Elwagdy, A., Barakat, A. F., …Jneid, H. (2022). Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials. European Journal of Internal Medicine, 105, 38 - 45. https://doi.org/10.1016/j.ejim.2022.07.015

BACKGROUND: Randomized controlled trials (RCTs) investigating the optimal screening strategy for atrial fibrillation (AF) have yielded conflicting results. OBJECTIVE: To examine the comparative efficacy of different AF screening strategies in old... Read More about Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials..