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Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis. (2020)
Journal Article
Rashid, & Mamas. (2020). Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis. Journal of Cardiovascular Medicine, 897-904. https://doi.org/10.2459/JCM.0000000000001110

BACKGROUND: The management of patients with severe but asymptomatic aortic stenosis is challenging. Evidence on early aortic valve replacement (AVR) versus symptom-driven intervention in these patients is unknown. METHODS: Electronic databases were s... Read More about Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis..

Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis (2020)
Journal Article
Mamas. (2020). Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis. Expert Review of Cardiovascular Therapy, https://doi.org/10.1080/14779072.2021.1845143

Objectives: Intravascular lithotripsy (IVL) clinical efficacy and safety in the treatment of calcified coronary artery disease (CAC) is not well known. We sought to assess IVL safety and efficacy in CAC.

Methods: A comprehensive online databases s... Read More about Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis.

Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes (2020)
Journal Article
Mohamed, M., Rashid, M., Farooq, S., Siddiqui, N., Parwani, P., Shiers, D., …Mamas, M. (2020). Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes. European Heart Journal, 41(Supplement_2), https://doi.org/10.1093/ehjci/ehaa946.3146

Background
Severe mental illness (SMI) is associated with an increased risk of cardiovascular disease and mortality. However, it is unclear whether SMI patients are just as likely to receive guideline-recommended therapy for AMI as those without men... Read More about Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes.

Trends of sex differences in outcomes of cardiac electronic device implantations in the United States (2020)
Journal Article
Mohamed, M., Volgman, A., Contractor, T., Sharma, P., Kwok, C., Martin, G., …Mamas, M. (2020). Trends of sex differences in outcomes of cardiac electronic device implantations in the United States. European Heart Journal, 41(Supplement_2), https://doi.org/10.1093/ehjci/ehaa946.0831

Background
There is limited evidence on the differences in procedural outcomes between sexes after de novo cardiac implantable electronic device implantation (CIED). Furthermore, it is unclear whether any sex-based disparities have changed over the... Read More about Trends of sex differences in outcomes of cardiac electronic device implantations in the United States.

Characteristics of Heart Failure Trials Associated With Under-Representation of Women as Lead Authors. (2020)
Journal Article
Mamas. (2020). Characteristics of Heart Failure Trials Associated With Under-Representation of Women as Lead Authors. Journal of the American College of Cardiology, 1919 - 1930. https://doi.org/10.1016/j.jacc.2020.08.062

BACKGROUND: Clinical trials change practice in cardiology, and leading them requires research training, mentorship, sponsorship, and networking. Women report challenges in obtaining these opportunities. OBJECTIVES: The purpose of this review was to e... Read More about Characteristics of Heart Failure Trials Associated With Under-Representation of Women as Lead Authors..

TCT CONNECT-41 Impact of Chronic Kidney Disease on Coronary Revascularization and In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction (2020)
Journal Article
Panchal, H., Zheng, S., White, C., Leinaar, E., Mukherjee, D., Mamas, M., …Paul, T. (2020). TCT CONNECT-41 Impact of Chronic Kidney Disease on Coronary Revascularization and In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction. Journal of the American College of Cardiology, 76(17), B18. https://doi.org/10.1016/j.jacc.2020.09.072

Background
Chronic kidney disease (CKD) in patients with ST-segment elevation myocardial infarction (STEMI) has been associated with worse outcomes. Our study sought to assess the impact of CKD on guideline-directed coronary revascularization and ou... Read More about TCT CONNECT-41 Impact of Chronic Kidney Disease on Coronary Revascularization and In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction.

TCT CONNECT-247 Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Bi-national Analysis Derived From the United Kingdom and United States (2020)
Journal Article
Nagaraja, V., Rashid, M., Anderson, H., Ludman, P., Kapadia, S., Starling, R., …Mamas, M. (2020). TCT CONNECT-247 Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Bi-national Analysis Derived From the United Kingdom and United States. Journal of the American College of Cardiology, 76(17), B109. https://doi.org/10.1016/j.jacc.2020.09.264

Background
Five years after transplantation, coronary allograft vasculopathy and late graft failure account for 32% of all mortality. The current role of percutaneous coronary intervention (PCI) in coronary allograft vasculopathy is unclear and cons... Read More about TCT CONNECT-247 Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Bi-national Analysis Derived From the United Kingdom and United States.

TCT CONNECT-266 Cobalt Chromium Biolimus Drug-Eluting Stents Compared With Stainless Steel Biolimus Drug-Eluting Stents: Final Results of BMX Alpha (2020)
Journal Article
Alexander Menown, I. B., Mamas, M., Cotton, J., Hildick-Smith, D., Eberli, F., Leibundgut, G., …Oldroyd, K. (2020). TCT CONNECT-266 Cobalt Chromium Biolimus Drug-Eluting Stents Compared With Stainless Steel Biolimus Drug-Eluting Stents: Final Results of BMX Alpha. Journal of the American College of Cardiology, 76(17), B116. https://doi.org/10.1016/j.jacc.2020.09.283

Background
Thinner stent struts may improve deliverability and conformability and reduce vessel injury. The final clinical outcomes of the thinner strut (84 to 88 μm) cobalt chromium biolimus eluting stent from the BioMatrix (BMX) Alpha registry are... Read More about TCT CONNECT-266 Cobalt Chromium Biolimus Drug-Eluting Stents Compared With Stainless Steel Biolimus Drug-Eluting Stents: Final Results of BMX Alpha.

Impact of COVID-19 on cardiac procedure activity in England and associated 30-day mortality (2020)
Journal Article
Mohamed, M. O., Banerjee, A., Clarke, S., de Belder, M., Patwala, A., Goodwin, A. T., …Mamas, M. (2021). Impact of COVID-19 on cardiac procedure activity in England and associated 30-day mortality. European Heart Journal - Quality of Care and Clinical Outcomes, 7(3), 247-256. https://doi.org/10.1093/ehjqcco/qcaa079

Background: Limited data exists on the impact of COVID-19 on national changes in cardiac procedure activity, including patient characteristics and clinical outcomes before and during the COVID-19 pandemic.

Methods and Results: All major cardiac pr... Read More about Impact of COVID-19 on cardiac procedure activity in England and associated 30-day mortality.

Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials (2020)
Journal Article
Mamas. (2020). Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials. Journal of the American College of Cardiology, 1919-1930. https://doi.org/10.1016/j.jacc.2020.08.062

Background
Clinical trials change practice in cardiology, and leading them requires research training, mentorship, sponsorship, and networking. Women report challenges in obtaining these opportunities.

Objectives
The purpose of this review was t... Read More about Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials.

Excess mortality in England and Wales during the first wave of the COVID-19 pandemic. (2020)
Journal Article
Mamas. (2020). Excess mortality in England and Wales during the first wave of the COVID-19 pandemic. Journal of Epidemiology and Community Health, 213 - 223. https://doi.org/10.1136/jech-2020-214764

BACKGROUND: Deaths during the COVID-19 pandemic result directly from infection and exacerbation of other diseases and indirectly from deferment of care for other conditions, and are socially and geographically patterned. We quantified excess mortalit... Read More about Excess mortality in England and Wales during the first wave of the COVID-19 pandemic..

Impact of COVID19 Pandemic on the Incidence and Management of Out of Hospital Cardiac Arrest in Patients Presenting with Acute Myocardial Infarction in England (2020)
Journal Article
Rashid, M., Gale, C. P., Curzen, N., Ludman, P., De Belder, M., Timmis, A., …Mamas, M. (2020). Impact of COVID19 Pandemic on the Incidence and Management of Out of Hospital Cardiac Arrest in Patients Presenting with Acute Myocardial Infarction in England. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 9(22), https://doi.org/10.1161/JAHA.120.018379

Background: Studies have reported significant reduction in acute myocardial infarction (AMI) related hospitalizations during the COVID19 pandemic. However, whether these trends are associated with increased incidence of Out of Hospital Cardiac Arrest... Read More about Impact of COVID19 Pandemic on the Incidence and Management of Out of Hospital Cardiac Arrest in Patients Presenting with Acute Myocardial Infarction in England.

Seasonality of stroke: Winter admissions and mortality excess: A Thailand National Stroke population database study. (2020)
Journal Article
Lorking, N., Wood, A. D., Tiamkao, S., Clark, A. B., Kongbunkiat, K., Bettencourt-Silva, J. H., …Myint, P. K. (2020). Seasonality of stroke: Winter admissions and mortality excess: A Thailand National Stroke population database study. Clinical Neurology and Neurosurgery, 106261 - ?. https://doi.org/10.1016/j.clineuro.2020.106261

OBJECTIVES: We examined the existence and potential burden of seasonality of stroke admissions and mortality within a tropical climate using cohort data collected between 1?st November 2003 and 31?st October 2012. PATIENTS AND METHODS: In a prospecti... Read More about Seasonality of stroke: Winter admissions and mortality excess: A Thailand National Stroke population database study..

Meta-Analysis Comparing the Safety and Efficacy of Prasugrel and Ticagrelor in Acute Coronary Syndrome. (2020)
Journal Article
Mamas. (2020). Meta-Analysis Comparing the Safety and Efficacy of Prasugrel and Ticagrelor in Acute Coronary Syndrome. American Journal of Cardiology, 22 - 28. https://doi.org/10.1016/j.amjcard.2020.07.017

Prasugrel and ticagrelor are preferred over clopidogrel for patients with acute coronary syndrome who underwent percutaneous coronary intervention. We sought to determine the relative merits of 1 agent over the other. Multiple databases were queried... Read More about Meta-Analysis Comparing the Safety and Efficacy of Prasugrel and Ticagrelor in Acute Coronary Syndrome..

Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report (2020)
Journal Article
Mamas. (2020). Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report. World Journal of Cardiology, 468 - 474. https://doi.org/10.4330/wjc.v12.i9.468

BACKGROUND Coronary artery vasospasm (CAV) is a reversible, transient form of vasoconstriction with clinical manifestations ranging from stable angina to acute coronary syndromes (ACS). Vasospasm of epicardial coronary arteries or associated micro-va... Read More about Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report.

Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report (2020)
Journal Article
Mamas. (2020). Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report. World Journal of Cardiology, 468 - 474. https://doi.org/10.4330/wjc.v12.i9.468

BACKGROUND Coronary artery vasospasm (CAV) is a reversible, transient form of vasoconstriction with clinical manifestations ranging from stable angina to acute coronary syndromes (ACS). Vasospasm of epicardial coronary arteries or associated micro-va... Read More about Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report.

Epidemiology and Clinical Outcomes of Patients With Inflammatory Bowel Disease Presenting With Acute Coronary Syndrome (2020)
Journal Article
Mamas, Pemmasani, G., Elgendy, I., Leighton, J. A., Aronow, W. S., & Tremaine, W. J. (2021). Epidemiology and Clinical Outcomes of Patients With Inflammatory Bowel Disease Presenting With Acute Coronary Syndrome. Inflammatory Bowel Diseases, 27(7), 1017-1025. https://doi.org/10.1093/ibd/izaa237

BACKGROUND: Inflammatory bowel disease (IBD) is associated with an increased acute coronary syndrome (ACS) risk. Data are limited regarding the epidemiology and outcomes of ACS in patients with IBD. METHODS: A retrospective cohort analysis of patient... Read More about Epidemiology and Clinical Outcomes of Patients With Inflammatory Bowel Disease Presenting With Acute Coronary Syndrome.

Temporal Trends and Outcomes in Utilization of Transcatheter and Surgical Aortic Valve Therapies in Aortic Valve Stenosis Patients with Heart Failure (2020)
Journal Article
Mamas. (2020). Temporal Trends and Outcomes in Utilization of Transcatheter and Surgical Aortic Valve Therapies in Aortic Valve Stenosis Patients with Heart Failure. International Journal of Clinical Practice, e13711 - ?. https://doi.org/10.1111/ijcp.13711

INTRODUCTIONS & AIMS: Heart failure (HF) is a common comorbidity in patients undergoing surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). We sought to access the temporal trends and outcomes of TAVR or SAVR i... Read More about Temporal Trends and Outcomes in Utilization of Transcatheter and Surgical Aortic Valve Therapies in Aortic Valve Stenosis Patients with Heart Failure.

Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. (2020)
Journal Article
Protty, M. B., Hussain, H. I., Gallagher, S., Al-Raisi, S., Aldalati, O., Farooq, V., …Kinnaird, T. (2021). Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions, 97(5), E653-E660. https://doi.org/10.1002/ccd.29251

INTRODUCTION: Excimer laser coronary atherectomy (ELCA) is a recognized adjunctive therapy utilized in the percutaneous management of complex coronary lesions. Studies examining its safety and utility have been limited by small sample sizes. Our stud... Read More about Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database..