Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion

Vasques, ER; Cunha, JEM; Coelho, AMM; Sampietre, SN; Patzina, RA; Abdo, EE; Nader, HB; Tersariol, ILS; Andrade De Lima, M; Godoy, CMG; Rodrigues, Tiago; Chaib, Eleazar; D’Albuquerque, Luiz A.C.

doi:10.1371/journal.pone.0149630

All Outputs (5)

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Studying polysaccharide-protein interactions under physiological conditions by conventional techniques is challenging. Ideally, macromolecules could be followed by both in vitro spectroscopy experiments as well as in tissues using microscopy, to enab... Read More about 19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy.

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Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion (2016)
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Background Ischemia and reperfusion (I/R) causes tissue damage and intracellular calcium levels are a factor of cell death. Sodium calcium exchanger (NCX) regulates calcium extrusion and Trisulfated Disaccharide (TD) acts on NCX decreasing intracell... Read More about Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion.