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All Outputs (12)

HaEmaturia After Transurethral resection of bladder Tumour (HEATT): A multicentre, regional collaborative analysis of factors associated with emergency re-admission with haematuria following TURBT (2023)
Journal Article
Sarmah, P. B., Al-Dhahir, W., Chellapuri, A., Damola, A., Eli, N., Foulger, R., …Chakravarti, A. (in press). HaEmaturia After Transurethral resection of bladder Tumour (HEATT): A multicentre, regional collaborative analysis of factors associated with emergency re-admission with haematuria following TURBT. Journal of Clinical Urology, https://doi.org/10.1177/20514158231190035

Objective: To calculate the re-admission rate with haematuria within 30 days of elective transurethral resection of bladder tumour (TURBT), and identify factors associated with this. Materials and Methods: This was a multicentre, retrospective audit,... Read More about HaEmaturia After Transurethral resection of bladder Tumour (HEATT): A multicentre, regional collaborative analysis of factors associated with emergency re-admission with haematuria following TURBT.

Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells (2022)
Journal Article
Kitchen, Li, & Reynisson. (2022). Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells. https://doi.org/10.1016/j.prmcm.2022.100074

Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associat... Read More about Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells.

Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells (2022)
Journal Article
Kitchen. (2022). Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells. International Journal of Molecular Sciences, 5854 - 5854. https://doi.org/10.3390/ijms23105854

Pluripotent stem cells (PSC) possess unlimited proliferation, self-renewal, and a differentiation capacity spanning all germ layers. Appropriate culture conditions are important for the maintenance of self-renewal, pluripotency, proliferation, differ... Read More about Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells.

370 Scrotal Ultrasound in Young Men with Acute Scrotal Pain: A Retrospective Consecutive Case Series Audit (2022)
Journal Article
Kitchen. (2022). 370 Scrotal Ultrasound in Young Men with Acute Scrotal Pain: A Retrospective Consecutive Case Series Audit. British Journal of Surgery, https://doi.org/10.1093/bjs/znac039.249

Abstract Introduction Although not recommended by EAU guidelines, many men with acute scrotal pain undergo ultrasound (US) to screen for occult tumours. This has low diagnostic yield and must be weighed against the increased risks of coronavirus due... Read More about 370 Scrotal Ultrasound in Young Men with Acute Scrotal Pain: A Retrospective Consecutive Case Series Audit.

Immunotherapy for non-muscle-invasive bladder cancer: from the origins of BCG to novel therapies (2021)
Journal Article
Unsworth-White, S. R., Kitchen, M. O., & Bryan, R. T. (2022). Immunotherapy for non-muscle-invasive bladder cancer: from the origins of BCG to novel therapies. Future Oncology, 18(1), 105-115. https://doi.org/10.2217/fon-2021-0781

Supplies of intravesical Bacillus Calmette-Guérin (BCG), the first-line treatment for most intermediate- and high-risk non-muscle-invasive bladder cancers (NMIBC), have proven unreliable over the past decade. This review considers the evolution of BC... Read More about Immunotherapy for non-muscle-invasive bladder cancer: from the origins of BCG to novel therapies.

93 Sexually Transmitted Infections Remain Under-Diagnosed and Under-Treated in Young Men Presenting with Acute Scrotal Pain (2021)
Journal Article
Thomas, M., Thursby, H., Kitchen, M., & Liu, S. (2021). 93 Sexually Transmitted Infections Remain Under-Diagnosed and Under-Treated in Young Men Presenting with Acute Scrotal Pain. British Journal of Surgery, 108(Supplement_2), Article ARTN znab134.364. https://doi.org/10.1093/bjs/znab134.364

Introduction Epididymitis or epididymo-orchitis causing acute scrotal pain in men ≤35 years is a common presentation to primary and secondary care.Most are caused by sexually-transmitted-infections in this age group. Failure to identify or treat STIs... Read More about 93 Sexually Transmitted Infections Remain Under-Diagnosed and Under-Treated in Young Men Presenting with Acute Scrotal Pain.

DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells (2021)
Journal Article
Kitchen. (2021). DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells. Cells, 1032 - 1032. https://doi.org/10.3390/cells10051032

The application of physiological oxygen (physoxia) concentrations is becoming increasingly commonplace within a mammalian stem cell culture. Human mesenchymal stem cells (hMSCs) attract widespread interest for clinical application due to their unique... Read More about DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.

DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity. (2020)
Journal Article
Kitchen. (2020). DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity. Scientific reports, 15360 - ?. https://doi.org/10.1038/s41598-020-72730-z

Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue have not been undertaken.... Read More about DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity..

HumanMethylation450K Array–Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer (2018)
Journal Article
Kitchen, M. O., Bryan, R. T., Emes, R. D., Luscombe, C. J., Cheng, K., Zeegers, M. P., …Fryer, A. A. (2018). HumanMethylation450K Array–Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer. Biomarkers in Cancer, 10, 1179299X1775192. https://doi.org/10.1177/1179299x17751920

Background: High-risk non-muscle invasive bladder cancer (HR-NMIBC) is a clinically unpredictable disease. Despite clinical risk estimation tools, many patients are undertreated with intra-vesical therapies alone, whereas others may be over-treated... Read More about HumanMethylation450K Array–Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer.

Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer (2016)
Journal Article
Kitchen, M. O., Bryan, R. T., Emes, R. D., Glossop, J. R., Luscombe, C., Cheng, K. K., …Farrell, W. E. (2016). Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer. Epigenetics, 11(3), 237-246. https://doi.org/10.1080/15592294.2016.1154246

High-grade non-muscle invasive bladder cancer (HG-NMIBC) is a clinically unpredictable disease with greater risks of recurrence and progression relative to their low-intermediate-grade counterparts. The molecular events, including those affecting the... Read More about Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer.

Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells (2015)
Journal Article
Kitchen, M. O., Yacqub-Usman, K., Emes, R. D., Richardson, A., Clayton, R. N., & Farrell, W. E. (2015). Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells. Pituitary, 18(5), 674-684. https://doi.org/10.1007/s11102-014-0630-5

Introduction Transgenic mice overexpressing the high mobility group A (HMGA) genes, Hmga1 or Hmga2 develop pituitary tumours and their overexpression is also a frequent finding in human pituitary adenomas. In some cases, increased expression of HMGA... Read More about Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.