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International variations in serum PTH and calcium levels and their mortality associations in peritoneal dialysis patients: Results from PDOPPS (2024)
Journal Article
Nitta, K., Bieber, B., Karaboyas, A., Johnson, D. W., Kanjanabuch, T., Kim, Y., …Kawanishi, H. (2024). International variations in serum PTH and calcium levels and their mortality associations in peritoneal dialysis patients: Results from PDOPPS. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 14(3), https://doi.org/10.1177/08968608241235516

Background: Mineral bone disorder (MBD) in chronic kidney disease (CKD) is associated with high symptom burden, fractures, vascular calcification, cardiovascular disease and increased morbidity and mortality. CKD-MBD studies have been limited in per... Read More about International variations in serum PTH and calcium levels and their mortality associations in peritoneal dialysis patients: Results from PDOPPS.

Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis (2024)
Journal Article
Jeyaraman, D., Walters, B., Bramham, K., Fish, R., Lambie, M., & Wu, P. (2024). Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis. BJOG: An International Journal of Obstetrics and Gynaecology, https://doi.org/10.1111/1471-0528.17807

Background Chronic kidney disease (CKD) is associated with an increased risk of adverse pregnancy outcomes, but the risk at different stages of CKD (defined by estimated glomerular filtration rate, eGFR) compared with women without CKD has not been... Read More about Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis.

Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England (2024)
Journal Article
Damery, S., Lambie, M., Williams, I., Coyle, D., Fotheringham, J., Solis-Trapala, I., …Davies, S. J. (in press). Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608241232200

Background: Disparities in home dialysis uptake across England suggest inequity and unexplained variation in access. We surveyed staff at all English kidney centres to identify patterns in service organisation/delivery and explore correlations with... Read More about Centre variation in home dialysis uptake: A survey of kidney centre practice in relation to home dialysis organisation and delivery in England.

Gastric Acid Suppression Therapy and its Association with Peritoneal Dialysis-Associated Peritonitis in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) (2023)
Journal Article
Goldman, S., Zhao, J., Bieber, B., Pisoni, R. L., Horowitz, L., Nessim, S. J., …Perl, J. (2023). Gastric Acid Suppression Therapy and its Association with Peritoneal Dialysis-Associated Peritonitis in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). Kidney360, 5(3), 370-379. https://doi.org/10.34067/kid.0000000000000325

Background Peritonitis is a major peritoneal dialysis–related complication. We determined whether gastric acid suppression (GAS) (proton pump inhibitor [PPI] or histamine-2 receptor antagonists [H2RAs]) use was associated with all-cause and organis... Read More about Gastric Acid Suppression Therapy and its Association with Peritoneal Dialysis-Associated Peritonitis in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).

Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis (2023)
Journal Article
Istanbuly, O., Belcher, J., Tabinor, M., Solis-Trapala, I., Lambie, M., & Davies, S. J. (in press). Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis. BMC Nephrology, 24(1), Article 312. https://doi.org/10.1186/s12882-023-03370-4

Background: Systemic inflammation, measured as circulating Interleukin-6 (IL-6) levels, is associated with cardiovascular and all-cause mortality in chronic kidney disease. However, this has not been convincingly demonstrated in a systematic review o... Read More about Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis.

An update on absolute and relative indications for dialysis treatment modalities (2023)
Journal Article
Lambie, M., & Davies, S. (2023). An update on absolute and relative indications for dialysis treatment modalities. Clinical Kidney Journal, 16(Supplement_1), i39-i47. https://doi.org/10.1093/ckj/sfad062

Background Choosing a dialysis modality is an important decision for people to make as their kidney failure progresses. In doing so, their options should be informed by any absolute or relative indications that may favour one modality over another. M... Read More about An update on absolute and relative indications for dialysis treatment modalities.

Standards of diabetes care and burden of hypoglycaemia in people with diabetes on peritoneal dialysis: Results from a real-world clinical audit (2023)
Journal Article
Wijewickrama, P., Onyema, M., Eid, H., Phare, N., Dick, J., Moutzouris, D., …Karalliedde, J. (in press). Standards of diabetes care and burden of hypoglycaemia in people with diabetes on peritoneal dialysis: Results from a real-world clinical audit. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/08968608231195492

There is limited data on the standards of diabetes care in people on peritoneal dialysis (PD). Our aim was to assess the standards of diabetes care and the burden of hypoglycaemia in people with diabetes on PD. We performed a retrospective study at t... Read More about Standards of diabetes care and burden of hypoglycaemia in people with diabetes on peritoneal dialysis: Results from a real-world clinical audit.

The Peritoneal Membrane and its Role in Peritoneal Dialysis. (2023)
Journal Article
Morelle, J., Lambie, M., Öberg, C. M., & Davies, S. (in press). The Peritoneal Membrane and its Role in Peritoneal Dialysis. Clinical Journal of the American Society of Nephrology, 10.2215/CJN.0000000000000282. https://doi.org/10.2215/CJN.0000000000000282

A healthy and functional peritoneal membrane is key to achieve sufficient ultrafiltration and to restore fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membrane function... Read More about The Peritoneal Membrane and its Role in Peritoneal Dialysis..

Narrative Review of Glycemic Management in People With Diabetes on Peritoneal Dialysis (2023)
Journal Article
Wijewickrama, P., Williams, J., Bain, S., Dasgupta, I., Chowdhury, T. A., Wahba, M., …Karalliedde, J. (2023). Narrative Review of Glycemic Management in People With Diabetes on Peritoneal Dialysis. Kidney International Reports, 8(4), 700-714. https://doi.org/10.1016/j.ekir.2023.01.040

There is an increasing number of people with diabetes on peritoneal dialysis (PD) worldwide. However, there is a lack of guidelines and clinical recommendations for managing glucose control in people with diabetes on PD. The aim of this review is to... Read More about Narrative Review of Glycemic Management in People With Diabetes on Peritoneal Dialysis.

IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata (2023)
Journal Article
Devuyst, O., Jakulj, L., Vervloet, M., Ruiz-Ortega, M., Rossignol, P., Rutherford, P., …Johnson, D. (2023). IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata. Kidney International Reports, 8(4), 912-915. https://doi.org/10.1016/j.ekir.2023.01.003

Peritoneal dialysis (PD) is a life-sustaining kidney replacement therapy for the increasing number of people with permanent kidney failure across all age groups worldwide. Although PD potentially offers socioeconomic and performance benefits over hem... Read More about IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata.

Management of adults with diabetes on dialysis: Summary of recommendations of the Joint British Diabetes Societies guidelines 2022 (2022)
Journal Article
Frankel, A. H., Wahba, M., Ashworth, V., Bedi, R., Berrington, R., Buckley, M., …Chowdhury, T. A. (2023). Management of adults with diabetes on dialysis: Summary of recommendations of the Joint British Diabetes Societies guidelines 2022. Diabetic Medicine, 40(4), https://doi.org/10.1111/dme.15027

Diabetes is the commonest cause of end-stage kidney disease in many parts of the world, and many people on dialysis programmes live with diabetes. Such people are vulnerable to complications from their diabetes, and their care may be fragmented due t... Read More about Management of adults with diabetes on dialysis: Summary of recommendations of the Joint British Diabetes Societies guidelines 2022.

Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle (2022)
Journal Article
Tshimologo, M., Allen, K., Coyle, D., Damery, S., Dikomitis, L., Fotheringham, J., …Davies, S. (2022). Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle. BMJ Open, e060922 - ?. https://doi.org/10.1136/bmjopen-2022-060922

INTRODUCTION: Use of home dialysis by centres in the UK varies considerably and is decreasing despite attempts to encourage greater use. Knowing what drives this unwarranted variation requires in-depth understanding of centre cultural and organisatio... Read More about Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle.

Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study. (2022)
Journal Article
Lambie, M., Zhao, J., McCullough, K., Davies, S. J., Kawanishi, H., Johnson, D. W., …Perl, J. (2022). Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study. Clinical Journal of the American Society of Nephrology, 17(6), 861-871. https://doi.org/10.2215/CJN.16341221

Background and objectives Quantifying contemporary peritoneal dialysis time on therapy is important for patients and providers. We describe time on peritoneal dialysis in the context of outcomes of hemodialysis transfer, death, and kidney transplanta... Read More about Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study..

Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK (2022)
Journal Article
Selvaskandan, H., Hull, K. L., Adenwalla, S., Ahmed, S., Cusu, M., Graham-Brown, M., …Burton, J. (2022). Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK. BMJ Open, 12(5), Article ARTN e054869. https://doi.org/10.1136/bmjopen-2021-054869

Objectives To assess the applicability of risk factors for severe COVID-19 defined in the general population for patients on haemodialysis. Setting A retrospective cross-sectional study performed across thirty four haemodialysis units in midlands... Read More about Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK.

Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis (2022)
Journal Article
Davies, & Lambie. (2022). Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis. Kidney International Reports, https://doi.org/10.1016/j.ekir.2022.02.016

Introduction Transition to hemodialysis (HD) is a common outcome in peritoneal dialysis (PD), but the associated mortality risk is poorly understood. This study sought to identify rates of and risk factors for mortality after transitioning from PD t... Read More about Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis.

Widening access to the specialised foundation programme (2022)
Journal Article
Lambie. (2022). Widening access to the specialised foundation programme. British Journal of Hospital Medicine, 1 - 7

The specialised foundation programme, previously known as the academic foundation programme, is an alternate foundation training pathway for doctors that are interested in research, medical education and leadership. The programme is highly competiti... Read More about Widening access to the specialised foundation programme.

AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. (2021)
Journal Article
Morelle, J., Marechal, C., Yu, Z., Debaix, H., Corre, T., Lambie, M., …Devuyst, O. (2021). AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. New England Journal of Medicine, 385, 1570 - 1580. https://doi.org/10.1056/NEJMoa2034279

BACKGROUND: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribut... Read More about AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis..

835 Evaluation of an International Virtual Teaching Series for UK Academic Foundation Programme Applications and Interviews: A Cross-Sectional Study (2021)
Journal Article
Youssef, S., Zaidi, S., Lambie, M., & Ahmed, S. (2021). 835 Evaluation of an International Virtual Teaching Series for UK Academic Foundation Programme Applications and Interviews: A Cross-Sectional Study. British Journal of Surgery, 108(Supplement_6), https://doi.org/10.1093/bjs/znab259.876

Background UK academic foundation programme (AFP) is an important steppingstone into academic surgical training, but there is paucity in undergraduate preparedness. We aimed to evaluate the effectiveness of a virtual webinar series to prepare student... Read More about 835 Evaluation of an International Virtual Teaching Series for UK Academic Foundation Programme Applications and Interviews: A Cross-Sectional Study.

Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. (2021)
Journal Article
Lambie, & Davies. (2021). Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. Trends in Endocrinology and Metabolism, 721 - 730. https://doi.org/10.1016/j.tem.2021.06.001

Diabetic nephropathy is highly correlated with the occurrence of other complications of type 1 diabetes (T1D) and type 2 diabetes (T2D) mellitus; for example, hypertension with cardiovascular disease (CVD) being the most frequent cause of death in pa... Read More about Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis..