Heparin derivatives for the targeting of multiple activities in the inflammatory response.

Veraldi, N; Hughes, AJ; Rudd, TR; Thomas, HB; Edwards, SW; Hadfield, L; Skidmore, MA; Siligardi, G; Cosentino, C; Shute, JK; Naggi, A; Yates, EA

doi:10.1016/j.carbpol.2014.09.079

The role of heparan sulfate in host macrophage infection by Leishmania species (2018)
Journal Article
Maciej-Hulme, M., Skidmore, M., & Price, H. (2018). The role of heparan sulfate in host macrophage infection by Leishmania species. Transactions, 46(4), 789-796. https://doi.org/10.1042/BST20170398

The leishmaniases are a group of neglected tropical diseases caused by parasites from the Leishmania genus. More than 20 Leishmania species are responsible for human disease, causing a broad spectrum of symptoms ranging from cutaneous lesions to a fa... Read More about The role of heparan sulfate in host macrophage infection by Leishmania species.

Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease (2018)
Journal Article
Mycroft-West, C. J., Yates, E. A., & Skidmore, M. A. (2018). Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease. Biochemical Society Transactions, 46(4), 919-929. https://doi.org/10.1042/bst20170404

Glycosaminoglycans (GAGs), present in the extracellular matrix, are exploited by numerous, distinct microbes for cellular attachment, adhesion, invasion and evasion of the host immune system. Glycosaminoglycans, including the widely used, clinical an... Read More about Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease.

An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy (2018)
Journal Article
Holman, J., Skidmore, M., & Yates, E. (2018). An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy. Plasma, 1(1), 78-79. https://doi.org/10.3390/plasma1010008

Since signal/noise ratios are proportional to the square root of the intensity, high intensity light sources are advantageous for many forms of UV–Vis and IR spectroscopy particularly with very low or high absorbance samples. We report the constructi... Read More about An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy.

Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection (2018)
Journal Article
Vicenzi, E., Pagani, I., Ghezzi, S., Taylor, S. L., Rudd, T. R., Lima, M. A., …Yates, E. A. (2018). Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection. Biochemical Society Transactions, 46, 609-617. https://doi.org/10.1042/BST20170399

Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), West Nile (WNV) and Zika (ZIKV) viruses, infect a broad range of hosts, ce... Read More about Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection.

Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans (2018)
Journal Article
Rogerson, E., Pelletier, J., Acosta-Serrano, A., Rose, C., Taylor, S., Guimond, S., …Yates, E. (2018). Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans. Pathogens an international, open access journal of pathogens and pathogen-host interactions, 7, https://doi.org/10.3390/pathogens7010032

Tsetse flies are the principal insect vectors of African trypanosomes-sleeping sickness in humans and Nagana in cattle. One of the tsetse fly species, Glossina morsitans morsitans, is host to the parasite, Trypanosoma brucei, a major cause of African... Read More about Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans.

In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes. (2017)
Journal Article
Kareem, N., Yates, E., Skidmore, M., & Hoole, D. (2018). In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes. Fish and Shellfish Immunology, 74, 213-222. https://doi.org/10.1016/j.fsi.2017.12.047

The rapid emergence of drug resistance, unfavourable immunosuppression and mounting evidence to suggest the deleterious accumulation of drug breakdown residues within animal tissues has driven a strong desire to move away from these current methods o... Read More about In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes..

A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence (2017)
Journal Article
Skidmore, M., Mohd Fadzli Mustaffa, K., Cooper, L. C., Guimond, S. E., Yates, E. A., & Craig, A. G. (2017). A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence. PloS one, 12(10), Article e0186276. https://doi.org/10.1371/journal.pone.0186276

A feature of mature Plasmodium falciparum parasitized red blood cells is their ability to bind surface molecules of the microvascular endothelium via the parasite-derived surface protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).... Read More about A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence.

Identification of heparin modifications and polysaccharide inhibitors of Plasmodium falciparum merozoite invasion that have potential for novel drug development. (2017)
Journal Article
Boyle, M. J., Skidmore, M., Dickerman, B., Cooper, L., Devlin, A., Yates, E., …Beeson, J. G. (2017). Identification of heparin modifications and polysaccharide inhibitors of Plasmodium falciparum merozoite invasion that have potential for novel drug development. Antimicrobial Agents and Chemotherapy, 61(11), https://doi.org/10.1128/AAC.00709-17

Despite recent successful control efforts, malaria remains a leading global health burden. Alarmingly, resistance to current antimalarials is increasing, and the development of new drug families is needed to maintain malaria control. Current antimala... Read More about Identification of heparin modifications and polysaccharide inhibitors of Plasmodium falciparum merozoite invasion that have potential for novel drug development..

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells (2017)
Journal Article
Ghezzi, S., Cooper, L., Rubio, A., Pagani, I., Rosaria Capobianchi, M., Ippolito, G., …Vicenzi, E. (2017). Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Research, 140, 13-17. https://doi.org/10.1016/j.antiviral.2016.12.023

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to tr... Read More about Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.

19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy (2016)
Journal Article
Lima, M. A., Cavalheiro, R. P., Viana, G. M., Meneghetti, M. C., Rudd, T. R., Skidmore, M., …Yates, E. A. (2016). 19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconjugate Journal, 34, 405-410. https://doi.org/10.1007/s10719-016-9723-x

Studying polysaccharide-protein interactions under physiological conditions by conventional techniques is challenging. Ideally, macromolecules could be followed by both in vitro spectroscopy experiments as well as in tissues using microscopy, to enab... Read More about 19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy.

Inhibition of influenza H5N1 invasion by modified heparin derivatives (2015)
Journal Article
Skidmore, M. A., Kajaste-Rudnitski, A., Wells, N. M., Guimond, S. E., Rudd, T. R., Yates, E. A., & Vicenzi, E. Inhibition of influenza H5N1 invasion by modified heparin derivatives. MedChemComm, 6(4), 640-646. https://doi.org/10.1039/c4md00516c

Influenza remains a serious health threat, with resistance to frontline drugs becoming more common, and new treatments urgently sought. One strategy for the inhibition of the attachment of influenza to host cells is to employ chemically modified hepa... Read More about Inhibition of influenza H5N1 invasion by modified heparin derivatives.

Heparin derivatives for the targeting of multiple activities in the inflammatory response. (2015)
Journal Article
Veraldi, N., Hughes, A., Rudd, T., Thomas, H., Edwards, S., Hadfield, L., …Yates, E. (2015). Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydrate Polymers, 400 - 407. https://doi.org/10.1016/j.carbpol.2014.09.079

An attractive strategy for ameliorating symptoms arising from the multi-faceted processes of excessive and/or continual inflammation would be to identify compounds able to interfere with multiple effectors of inflammation. The well-tolerated pharmace... Read More about Heparin derivatives for the targeting of multiple activities in the inflammatory response..

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