All Outputs (25)

A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors: General Continuous Flow Method for Pd-Catalysed Carbonylations (2014)
Journal Article
Gross, U., Koos, P., O'Brien, M., Polyzos, A., & Ley, S. V. (2014). A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors: General Continuous Flow Method for Pd-Catalysed Carbonylations. European Journal of Organic Chemistry, 2014(29), 6418-6430. https://doi.org/10.1002/ejoc.201402804

A series of continuous flow chemistry processes that facilitate the palladium-catalysed carbonylation of aryl and vinyl iodides and aryl bromides with a range of alkoxy, hydroxy and amino nucleophiles is reported. Harnessing a semipermeable Teflon® A... Read More about A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors: General Continuous Flow Method for Pd-Catalysed Carbonylations.

Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia (2013)
Journal Article
Pastre, J. C., Browne, D. L., O’Brien, M., & Ley, S. V. (2013). Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia. Organic Process Research and Development, 17(9), 1183-1191. https://doi.org/10.1021/op400152r

The development of a tube-in-tube reactor based on a semipermeable polymer membrane has enabled the efficient transfer of gases into liquid flow streams. In this work we describe the scalability and throughput of this reactor when applied to ammonia... Read More about Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia.

Camera-enabled techniques for organic synthesis (2013)
Journal Article
Ley, S. V., Ingham, R. J., O’Brien, M., & Browne, D. L. (in press). Camera-enabled techniques for organic synthesis. Beilstein Journal of Organic Chemistry, 9, 1051-1072. https://doi.org/10.3762/bjoc.9.118

A great deal of time is spent within synthetic chemistry laboratories on non-value-adding activities such as sample preparation and work-up operations, and labour intensive activities such as extended periods of continued data collection. Using digit... Read More about Camera-enabled techniques for organic synthesis.

Synthesis of spongistatin 2 employing a new route to the EF fragment (2013)
Journal Article
Kraus, H., Français, A., O'Brien, M., Frost, J., Diéguez-Vázquez, A., Polara, A., …Ley, S. V. (2013). Synthesis of spongistatin 2 employing a new route to the EF fragment. Chemical Science, 4(5), 1989. https://doi.org/10.1039/c3sc50304f

An improved route to the EF fragment of the spongistatins has been developed and employed in a synthesis of spongistatin 2. The C48–C51 diene side chain, which lacks the chlorine substituent present in spongistatin 1, presented some compatibility iss... Read More about Synthesis of spongistatin 2 employing a new route to the EF fragment.

Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes (2012)
Journal Article
Bourne, S. L., O'Brien, M., Kasinathan, S., Koos, P., Tolstoy, P., Hu, D. X., …Ley, S. V. (2013). Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes. ChemCatChem, 5(1), 159-172. https://doi.org/10.1002/cctc.201200778

Two tandem flow chemistry processes have been developed. A single palladium-catalysed Heck reaction with ethylene gas provides an efficient synthesis for functionalised styrenes. Through further elaboration the catalyst becomes multi-functional and p... Read More about Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes.