Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53.

Akram, Khondoker M.; Lomas, Nicola J.; Forsyth, Nicholas R.; Spiteri, Monica A

All Outputs (5)

Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs (2014)
Journal Article
Dunphy, S. E., Bratt, J. A., Akram, K. M., Forsyth, N. R., & El Haj, A. J. (2014). Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs. Journal of the Mechanical Behavior of Biomedical Materials, 38, 251-259. https://doi.org/10.1016/j.jmbbm.2014.04.005

In this study, collagen–elastin constructs were prepared with the aim of producing a material capable of mimicking the mechanical properties of a single alveolar wall. Collagen has been used in a wide range of tissue engineering applications; however... Read More about Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs.

Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner (2014)
Presentation / Conference
Dale, T. P., De Castro, A., Parkinson, E. K., Kuiper, N. J., & Forsyth, N. R. (2014, June). Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner. Poster presented at Tissue Engineering & Regenerative Medicine International Society, European Chapter Meeting, Magazzini del Cotone Congress Center, Genova, Italy

Introduction: Limited therapeutic options for the treatment of cartilage damage have driven the development of cell therapy alternatives. How-ever, many of the relevant cell types are difficult to study due to the rapid onset of replicative senescenc... Read More about Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner.

Three-dimensional hypoxic culture of human mesenchymal stem cells encapsulated in a photocurable, biodegradable polymer hydrogel: A potential injectable cellular product for nucleus pulposus regeneration (2014)
Journal Article
Kumar, D., Gerges, I., Tamplenizza, M., Lenardi, C., Forsyth, N. R., & Liu, Y. (2014). Three-dimensional hypoxic culture of human mesenchymal stem cells encapsulated in a photocurable, biodegradable polymer hydrogel: A potential injectable cellular product for nucleus pulposus regeneration. Acta biomaterialia, 10(8), 3463-3474. https://doi.org/10.1016/j.actbio.2014.04.027

Nucleus pulposus (NP) tissue damage can induce detrimental mechanical stresses and strains on the intervertebral disc, leading to disc degeneration. This study demonstrates the potential of a novel, photo-curable, injectable, synthetic polymer hydrog... Read More about Three-dimensional hypoxic culture of human mesenchymal stem cells encapsulated in a photocurable, biodegradable polymer hydrogel: A potential injectable cellular product for nucleus pulposus regeneration.

Vibrational spectroscopy in stem cell characterisation: is there a niche? (2014)
Journal Article
Sulé-Suso, J., Forsyth, N., Untereiner, V., & Sockalingum, G. (2014). Vibrational spectroscopy in stem cell characterisation: is there a niche?. Trends in Biotechnology, 32(5), 254-262. https://doi.org/10.1016/j.tibtech.2014.03.002

Vibrational spectroscopy using both infrared and Raman spectroscopies has been used in recent years with the aim to aid clinicians in disease diagnosis. More recently, these techniques have been applied to study stem cell differentiation and to deter... Read More about Vibrational spectroscopy in stem cell characterisation: is there a niche?.

Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. (2014)
Journal Article
Akram, K. M., Lomas, N. J., Forsyth, N. R., & Spiteri, M. A. (2014). Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. International Journal of Clinical and Experimental Pathology, 7(2), 552-564

Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating, and fatal lung disease of unknown aetiology with no current cure. The pathogenesis of IPF remains unclear but repeated alveolar epithelial cell (AEC) injuries and subsequent apoptosi... Read More about Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53..