Fabrication and characterization of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance

Chen, Zhichao; Zhang, Xianglin; Yang, Yang; Zhou, Kui; Wragg, Nicholas; Liu, Yang; Lewis, Mark; Liu, Changqing

doi:10.1016/j.ceramint.2016.09.160

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device (2021)
Journal Article
Wragg, N. (2021). Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Molecular Therapy - Methods and Clinical Development, 551-566. https://doi.org/10.1016/j.omtm.2021.10.015

Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir... Read More about Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device.

The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures (2021)
Journal Article
Andersen, C., Wragg, N., Shariatzadeh, M., & Wilson, S. L. (2021). The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures. Current Osteoporosis Reports, 19, 1-14. https://doi.org/10.1007/s11914-020-00643-x

PURPOSE OF REVIEW: The treatment of non-union fractures represents a significant challenge for orthopaedic surgeons. In recent years, biologic agents have been investigated and utilised to support and improve bone healing. Among these agents, platele... Read More about The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures.

Cryopreservation of Mesenchymal Stem Cells Using Medical Grade Ice Nucleation Inducer. (2020)
Journal Article
Wragg, N. (2020). Cryopreservation of Mesenchymal Stem Cells Using Medical Grade Ice Nucleation Inducer. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms21228579

Mesenchymal stem cells (MSCs) can differentiate into multiple different tissue lineages and have favourable immunogenic potential making them an attractive prospect for regenerative medicine. As an essential part of the manufacturing process, preserv... Read More about Cryopreservation of Mesenchymal Stem Cells Using Medical Grade Ice Nucleation Inducer..

Platelet Rich Plasma as a Treatment Method for Rotator Cuff Tears (2020)
Journal Article
Wragg, N. (2020). Platelet Rich Plasma as a Treatment Method for Rotator Cuff Tears. SN Comprehensive Clinical Medicine, 2293 - 2299. https://doi.org/10.1007/s42399-020-00500-z

<jats:title>Abstract</jats:title><jats:p>The prevalence of the rotator cuff (RC) tears is ~?21% in the general population, with higher incidences in individuals over 50. Irrespective of surgical repair techniques employed, re-tear rates are alarmingl... Read More about Platelet Rich Plasma as a Treatment Method for Rotator Cuff Tears.

Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis. (2020)
Journal Article
Claire Doyle, E., Wragg, N., & Louise Wilson, S. (2020). Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy, 28, 3827–3842. https://doi.org/10.1007/s00167-020-05859-z

PURPOSE: This review aimed to evaluate the efficacy of intra-articular injections of bone marrow derived mesenchymal stem cells (BM-MSCs) for the treatment of knee osteoarthritis (KOA). METHODS: This narrative review evaluates recent English language... Read More about Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis..

Development of a 3D Tissue-Engineered Skeletal Muscle and Bone Co-culture System. (2020)
Journal Article
Wragg, N. (2020). Development of a 3D Tissue-Engineered Skeletal Muscle and Bone Co-culture System. Biotechnology Journal, e1900106 - ?. https://doi.org/10.1002/biot.201900106

In vitro 3D tissue-engineered (TE) structures have been shown to better represent in vivo tissue morphology and biochemical pathways than monolayer culture, and are less ethically questionable than animal models. However, to create systems with even... Read More about Development of a 3D Tissue-Engineered Skeletal Muscle and Bone Co-culture System..

Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. (2019)
Journal Article
Wragg, N. (2019). Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Molecular Neurobiology, 6156 - 6167. https://doi.org/10.1007/s12035-019-1500-y

Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a... Read More about Systematic Review of miRNA as Biomarkers in Alzheimer's Disease..

Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. (2019)
Journal Article
Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377, 153 - 159. https://doi.org/10.1007/s00441-019-03016-8

There is a current need for a therapy that can alleviate the social and economic burden that presents itself with debilitating and recurring musculoskeletal soft tissue injuries and disorders. Currently, several therapies are emerging and undergoing... Read More about Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing..

Development of tissue-engineered skeletal muscle manufacturing variables. (2019)
Journal Article
Wragg, N. (2019). Development of tissue-engineered skeletal muscle manufacturing variables. Biotechnology and Bioengineering, 2364 - 2376. https://doi.org/10.1002/bit.27074

Three-dimensional tissue-engineered structures enable more representative determination of novel drug or material effects on tissue than traditional monolayer cell cultures. This study sought to better understand how key manufacturing variables affec... Read More about Development of tissue-engineered skeletal muscle manufacturing variables..

A critical review of current progress in 3D kidney biomanufacturing: advances, challenges, and recommendations (2019)
Journal Article
Wragg, N., Burke, L., & Wilson, S. L. (2019). A critical review of current progress in 3D kidney biomanufacturing: advances, challenges, and recommendations. Renal Replacement Therapy, 5, Article 18. https://doi.org/10.1186/s41100-019-0218-7

The widening gap between organ availability and need is resulting in a worldwide crisis, particularly concerning kidney transplantation. Regenerative medicine options are becoming increasingly advanced and are taking advantage of progress in novel ma... Read More about A critical review of current progress in 3D kidney biomanufacturing: advances, challenges, and recommendations.

The use of PRP injections in the management of knee osteoarthritis. (2019)
Journal Article
O’Connell, B., Wragg, N., & Louise Wilson, S. (2019). The use of PRP injections in the management of knee osteoarthritis. Cell and Tissue Research, 376, 143 - 152. https://doi.org/10.1007/s00441-019-02996-x

Osteoarthritis (OA) is a degenerative disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture that commonly affects the knee and/or hip joints. It is a major world public health problem a... Read More about The use of PRP injections in the management of knee osteoarthritis..

Rotator Cuff Repair Augmentation Using Osteoinductive Growth Factors (2019)
Journal Article
Wragg, N. (2019). Rotator Cuff Repair Augmentation Using Osteoinductive Growth Factors. SN Comprehensive Clinical Medicine, 267 - 276. https://doi.org/10.1007/s42399-019-0041-z

Rotator cuff injuries (RCIs) present a major health problem due to high incidences of degenerative tears greater than 3 cm and prevalence of re-tears following surgical procedures. Since healing and functional restoration relies upon bone ingrowth in... Read More about Rotator Cuff Repair Augmentation Using Osteoinductive Growth Factors.

Fabrication and characterization of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance (2017)
Journal Article
Chen, Z., Zhang, X., Yang, Y., Zhou, K., Wragg, N., Liu, Y., …Liu, C. (2017). Fabrication and characterization of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance. Ceramics International, 43(1 Part A), 336-344. https://doi.org/10.1016/j.ceramint.2016.09.160

To improve the biological performance of hydroxyapatite scaffolds in bone tissue engineering, graphite was used as porogen to create additional micro/nanoporosity to macroporosity, resulting in hierarchical porosity. For maximum imitation of natural... Read More about Fabrication and characterization of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance.

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