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Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes (2020)
Journal Article
Chen, L., Wang, C., Forsyth, N. R., & Wu, P. (2020). Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes. Stem Cell Research and Therapy, 11, Article 319. https://doi.org/10.1186/s13287-020-01828-y

Background Gestational diabetes (GDM) is a common complication of pregnancy. The impact of pregnancy complications on placental function suggests that extraembryonic stem cells in the placenta may also be affected during pregnancy. Neonatal tissue-d... Read More about Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes.

Menopausal Hormone Therapy- A Comprehensive Review (2020)
Journal Article
Wu. (2020). Menopausal Hormone Therapy- A Comprehensive Review. Current Atherosclerosis Reports, 22, Article 33. https://doi.org/10.1007/s11883-020-00854-8

Purpose of Review For decades the medical community recommended menopausal hormone therapy (MHT) for prevention of atherosclerotic cardiovascular disease (ASCVD) and osteoporosis in addition to relieving unpleasant vasomotor and genitourinary sympto... Read More about Menopausal Hormone Therapy- A Comprehensive Review.

Role of placental fibrinogen-like protein 1 in gestational diabetes (2020)
Journal Article
Kang, L., Li, H., Ou, H., Wu, P., Wang, S., Chang, C., …Wu, H. (2020). Role of placental fibrinogen-like protein 1 in gestational diabetes. Translational Research, The Journal of Laboratory and Clinical Medicine, 218, 73-80. https://doi.org/10.1016/j.trsl.2020.01.001

In view of the increasing prevalence of gestational diabetes mellitus (GDM) and the increased risks of delivering a macrosomic infant, developing preeclampsia, and suffering a perinatal death due to GDM, GDM has emerged as a growing public health pro... Read More about Role of placental fibrinogen-like protein 1 in gestational diabetes.

Temporal Changes in Hypertensive Disorders of Pregnancy and Impact on Cardiovascular and Obstetric Outcomes (2020)
Journal Article
Wu, P., Chew-Graham, C. A., Maas, A. H., Chappell, L. C., Potts, J. E., Gulati, M., …Mamas, M. A. (2020). Temporal Changes in Hypertensive Disorders of Pregnancy and Impact on Cardiovascular and Obstetric Outcomes. American Journal of Cardiology, 125(10), 1508-1516. https://doi.org/10.1016/j.amjcard.2020.02.029

Hypertensive disorders of pregnancy (HDP) are a major cause of maternal morbidity. However, short-term outcomes of HDP subgroups remain unknown. Using National Inpatient Sample database, all delivery hospitalizations between 2004 and 2014 with or wit... Read More about Temporal Changes in Hypertensive Disorders of Pregnancy and Impact on Cardiovascular and Obstetric Outcomes.

Obstetrics and Gynecologic History - A Missed Opportunity for Cardiovascular Risk Assessment (2020)
Journal Article
Wu. (2020). Obstetrics and Gynecologic History - A Missed Opportunity for Cardiovascular Risk Assessment. https://doi.org/10.1016/j.jaccas.2019.11.035

Atherosclerotic cardiovascular disease (ASCVD) remains a significant cause of morbidity and mortality in women, with the event rates particularly rising in young women. Women are disproportionately affected by traditional cardiovascular (CV) risk fac... Read More about Obstetrics and Gynecologic History - A Missed Opportunity for Cardiovascular Risk Assessment.

Obstetrics and Gynecological History (2020)
Journal Article
Park, K., Wu, P., & Gulati, M. (2020). Obstetrics and Gynecological History. JACC: Case Reports, 2(1), 161 - 163. https://doi.org/10.1016/j.jaccas.2019.11.035

Atherosclerotic cardiovascular disease (ASCVD) remains a significant cause of morbidity and mortality in women, with event rates rising particularly in young women. Women are disproportionately affected by traditional cardiovascular (CV) risk factors... Read More about Obstetrics and Gynecological History.

Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses (2019)
Journal Article
Watson, L., Loke, Y., Mallen, C., Mamas, M., Gulati, M., Kwok, C., …Wu, P. (2019). Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses. European Journal of Preventive Cardiology, 26(13), 1415-1429. https://doi.org/10.1177/2047487319843667

Aims The optimal diet for cardiovascular health is controversial. The aim of this review is to summarize the highest level of evidence and rank the risk associated with each individual component of diet within its food group. Methods and results... Read More about Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses.

Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial (2019)
Journal Article
Wu. (2019). Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial. The Lancet, 394(10204), 1181 - 1190. https://doi.org/10.1016/S0140-6736%2819%2931963-4

BACKGROUND: In women with late preterm pre-eclampsia, the optimal time to initiate delivery is unclear because limitation of maternal disease progression needs to be balanced against infant complications. The aim of this trial was to determine whethe... Read More about Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial.

Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics (2019)
Journal Article
Mamas, & Wu. (2019). Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics. Journal of Women's Health, 1037-1050. https://doi.org/10.1089/jwh.2018.7480

Globally, cardiovascular disease is the most common cause of mortality in women accounting for 1 in 3 deaths. There remains an under recognition of cardiovascular disease as well as a lack of awareness of risk in women. Promotion of cardiovascular di... Read More about Pregnancy as a Predictor of Maternal Cardiovascular Disease: The era of CardioObstetrics.

Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics (2019)
Journal Article
Mamas, & Wu. (2019). Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics. Journal of Women's Health, 1037 - 1050. https://doi.org/10.1089/jwh.2018.7480

Globally, cardiovascular disease (CVD) is the most common cause of mortality in women accounting for one in three deaths. There remains an under recognition of CVD as well as a lack of awareness of risk in women. Promotion of CVD prevention is essent... Read More about Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics.

Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma (2018)
Presentation / Conference
Shiau, A. L., Su, Y. C., Feng, Y. H., Huang, Y. S., Wu, P., & Wu, C. L. (2018, October). Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. Paper presented at Changing the Face of Modern Medicine: Stem Cell and Gene Therapy Organized Jointly by the European Society of Gene & Cell Therapy (ESGCT), International Society for Stem Cell Research (ISSCR) and the French Society of Gene and Cell Therapy (SFTCG), Lausanne, Switzerland

The Factor IX (FIX) gene therapy (BAX335) was produced in small-scale for hemophilia-B patients in clinical phase I/II. In the course of the internal BAX335 process development, the small-scale clinical product was compared to BAX335 developed using... Read More about Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma.

Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma (2018)
Presentation / Conference
Shiau, A. . L., Su, Y. . C., Feng, Y. . H., Huang, Y. . S., Wu, P., & Wu, C. . L. (2018, October). Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. Poster presented at Changing the Face of Modern Medicine: Stem Cell and Gene Therapy Organized Jointly by the European Society of Gene & Cell Therapy (ESGCT), International Society for Stem Cell Research (ISSCR) and the French Society of Gene and Cell Therapy (SFTCG), Lausanne, Switzerland

The elongation of long-chain fatty acids family member 6(Elovl6), a key enzyme in lipogenesis, catalyzes the elongation of saturated and monounsaturated fatty acids. Insulin resistance is associated with upregulation of Elovl6, which has been linkedt... Read More about Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma.

CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE (2018)
Presentation / Conference
Chen, L., Merkhan, M., Forsyth, N. R., & Wu, P. (2018, September). CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE. Poster presented at International Federation of Placenta Associations Meeting, Tokyo, Japan

Objectives: Chorionic and amniotic MSCs (CMSCs/AMSCs) are derived from different sides of placental membrane. Women with a history of gestational diabetes mellitus have a high risk of developing subsequent diabetes. As cell therapy is a promising... Read More about CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE.

Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis (2018)
Presentation / Conference
Wu, P., Gulati, M., Kwok, C., Wong, C., Narain, A., O'Brien, S., …Mamas, M. (2018, April). Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis. Poster presented at British Maternal & Fetal Medicine Society (BMFMS) 20th Annual Conference 2018, Brighton, UK

Objectives We aimed to systematically evaluate and summarise the evidence on the relationship between preterm birth (

Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies (2018)
Journal Article
Wu, P., Farrell, W., Haworth, K., Emes, R., Kitchen, M., Glossop, J., …Fryer, A. (2018). Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, 122-128. https://doi.org/10.1080/15592294.2016.1166321

Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450K array analysis to det... Read More about Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.

Polycystic ovarian syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care (2017)
Journal Article
Heald, A. H., Livingston, M., Holland, D., Robinson, J., Moreno, G. Y., Donnahey, G., …Fryer, A. A. (2018). Polycystic ovarian syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. International Journal of Clinical Practice, 72(1), Article ARTN e13046. https://doi.org/10.1111/ijcp.13046

Introduction Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age. We examined the specific tests that are done in primary care to lead to the diagnosis of PCOS, and to support the diagno... Read More about Polycystic ovarian syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care.