Skip to main content

Research Repository

Advanced Search

All Outputs (57)

Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma (1997)
Journal Article
Jahnke, V., Strange, R., Matthias, C., & Fryer, A. (1997). Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. European Archives of Oto-Rhino-Laryngology, 254, S147–S149. https://doi.org/10.1007/BF02439747

While cigarette smoking and alcohol consumption have been linked to laryngeal squamous cell carcinoma (SCC), the role of genetic factors in determining individual susceptibility is unknown. We describe the role of allelism at the glutathione S-transf... Read More about Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma.

Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. (1997)
Journal Article
Hajeer, A., John, S., Ollier, W. E., Silman, A. J., Dawes, P., Hassell, A., …Worthington, J. (1997). Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. Journal of Rheumatology, 24(1), 217-219

We investigated whether tumor necrosis factor (TNF) microsatellite polymorphisms are associated with sex and age at disease onset in rheumatoid arthritis (RA). A case-control study was used to compare the frequencies of TNF microsatellite alleles in... Read More about Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA..

Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. (1996)
Journal Article
Jahnke, V., Matthias, C., Fryer, A., & Strange, R. (1996). Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. American Journal of Surgery, 172(6), 671-673. https://doi.org/10.1016/s0002-9610%2896%2900298-x

Purpose While cigarette smoking and alcohol consumption are recognized covariates for laryngeal carcinoma, the role of genetic factors in determining individual susceptibility is unknown. We describe the influence of polymorphism in carcinogen-metab... Read More about Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx..

Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression (1996)
Journal Article
Sarhanis, P., Redman, C., Perrett, C., Brannigan, K., Clayton, R., Hand, P., …Strange, R. (1996). Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression. British journal of cancer, 1757 - 1761. https://doi.org/10.1038/bjc.1996.626

The importance of polymorphism in the glutathione S-transferase GSTM1, GSTT1 and, cytochrome P450, CYP2D6 loci in the pathogenesis of epithelial ovarian cancer has been assessed in two studies; firstly, a case-control study designed to determine the... Read More about Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression.

Association of homozygosity for glutathione-S-transferase GSTM1 null alleles with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus. (1996)
Journal Article
Ollier, W., Davies, E., Snowden, N., Alldersea, J., Fryer, A., Jones, P., & Strange, R. (1996). Association of homozygosity for glutathione-S-transferase GSTM1 null alleles with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus. Arthritis and Rheumatology, 39(10), 1763-1764. https://doi.org/10.1002/art.1780391023

Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. (1996)
Journal Article
Lear, J. T., Heagerty, A. H., Smith, A., Bowers, B., Rowland Payne, C., Dale Smith, C., …Strange, R. C. (1996). Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis, 17(9), 1891–1896. https://doi.org/10.1093/carcin/17.9.1891

The genetic factors that mediate the pathogenesis of multiple primary cutaneous basal cell carcinomas (BCC) are largely unclear. Thus, some patients suffer many BCC (>30) and/or rapid accrual (number of tumours/year from first presentation) of furthe... Read More about Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual..

Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. (1996)
Journal Article
Hand, P. A., Inskip, A., Gilford, J., Alldersea, J., Elexpuru-Camiruaga, J., Hayes, J. D., …Fryer, A. A. (1996). Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. Carcinogenesis, 17(9), 1919–1922. https://doi.org/10.1093/carcin/17.9.1919

We describe studies to assess the influence of polymorphism in the human glutathione S-transferase GSTM3 gene on susceptibility to high grade astrocytoma. Immunohisto-chemical studies using a GSTM3-specific antiserum identified expression of the GSTM... Read More about Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma..

Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. (1996)
Journal Article
Yengi, L., Inskip, A., Gilford, J., Alldersea, J., Bailey, L., Smith, A., …Fryer, A. A. (1996). Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. Cancer Research, 56, 1974-1977

The influence of polymorphism in the glutathione S-transferase, GSTM3 gene on susceptibility to cutaneous basal cell carcinoma (BCC) has been investigated. We have reported previously two GSTM3 alleles, GSTM3*A and GSTM3*B, distinguished by a recogni... Read More about Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma..

Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. (1996)
Journal Article
Deakin, M., Elder, J., Hendrickkse, C., Peckham, D., Leopard, D., Bell, D. A., …Strange, R. C. (1996). Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis, 17(4), 881–884. https://doi.org/10.1093/carcin/17.4.881

Allelism in glutathione S-transferase GSTM1 and GSTT1 has been suggested as a risk factor in various cancers. Accordingly, we describe a group of case-control studies carried out to identify associations between GSTT1 genotypes and susceptibility to... Read More about Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers..

Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. (1996)
Journal Article
Heagerty, A., Smith, A., English, J., Lear, J., Perkins, W., Bowers, B., …Strange, R. (1996). Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. British journal of cancer, 73, 44 - 48. https://doi.org/10.1038/bjc.1996.8

The factors that determine development of single and multiple primary cutaneous basal cell carcinomas (BCCs) are unclear. We describe a case-control study firstly, to examine the influence of allelism at the glutathione S-transferase GSTM1 and GSTT1... Read More about Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender..

Identification of polymorphism at the glutathione s-transferase, GSTM3 locus: Evidence for linkage with GSTMI*A (1995)
Journal Article
Inskip, A., Elexperu-Camiruaga, J., Buxton, N., Dias, P. S., MacIntosh, J., Campbell, D., …Fryer, A. A. (1995). Identification of polymorphism at the glutathione s-transferase, GSTM3 locus: Evidence for linkage with GSTMI*A. Biochemical Journal, 312(3), 713–716. https://doi.org/10.1042/bj3120713

Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation... Read More about Identification of polymorphism at the glutathione s-transferase, GSTM3 locus: Evidence for linkage with GSTMI*A.

[Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma] (1995)
Journal Article
Jahnke, V., Strange, R., Matthias, C., & Fryer, A. (1995). [Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma]. Laryngo-Rhino-Otologie, 74(11), 691-694. https://doi.org/10.1055/s-2007-997826

Background While cigarette smoking and alcohol consumption have been linked to laryngeal carcinoma, the role of genetic factors in determining individual susceptibility is unknown. We describe the role of allelism at glutathione-S-transferase GSTM1,... Read More about [Initial results of glutathione-S-transferase GSTM1 and GSTT1 genotypes and genetic predisposition for laryngeal carcinoma].

Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes. (1995)
Journal Article
Duncan, H., Swanx, C., Green, J., Jones, P., Brannigan, K., Alldersea, J., …Strange, R. C. (1995). Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes. Clinica Chimica Acta, 240(1), 53-61. https://doi.org/10.1016/0009-8981%2895%2906127-4

The polymorphic glutathione S-transferase GSTM1 and GSTT1 loci are attractive candidates for susceptibility to ulcerative colitis and Crohn's disease because their enzymes catalyse the detoxification of products of oxidative stress and tobacco-derive... Read More about Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes..

GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp. (1995)
Journal Article
Perrett, C. W., Clayton, R. N., Pistorello, M., Boscaro, M., Scanarini, M., Bates, A. S., …Strange, R. C. (1995). GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp. Carcinogenesis, 16(7), 1643–1645. https://doi.org/10.1093/carcin/16.7.1643

We describe studies to determine if susceptibility to pituitary tumours is associated with the putatively high risk GSTM1 null and CYP2D6 EM genotypes. Frequency distributions of these genotypes were similar in cases and controls though the frequency... Read More about GSTM1 and CYP2D6 genotype frequencies in patients with pituitary tumours: effects on P53, ras and gsp..

Studies on glutathione S-transferase GSTM1 and GSTT1 genotypes and susceptibility to laryngeal cancer,ERSTE ERGEBNISSE UBER GLUTATHION-S-TRANSFERASE GSTM1 UND GSTT1 GENOTYPEN UND DIE GENETISCHE PRADISPOSITION BEIM LARYNXKARZINOM (1995)
Journal Article
Jahnke, V., Strange, R., Matthias, C., & Fryer, A. (1995). Studies on glutathione S-transferase GSTM1 and GSTT1 genotypes and susceptibility to laryngeal cancer,ERSTE ERGEBNISSE UBER GLUTATHION-S-TRANSFERASE GSTM1 UND GSTT1 GENOTYPEN UND DIE GENETISCHE PRADISPOSITION BEIM LARYNXKARZINOM. Laryngo-Rhino-Otologie, 74(11), 691-694. https://doi.org/10.1055/s-2007-997826

Theta class glutathione s-transferase gstt1 genotypes and susceptibility to cervical neoplasia: Interactions with gstm1, cyp2d6 and smoking (1994)
Journal Article
Warwick, A., Sarhanis, P., Redman, C., Pemble, S., Taylor, J. B., Ketterer, B., …Strange, R. C. (1994). Theta class glutathione s-transferase gstt1 genotypes and susceptibility to cervical neoplasia: Interactions with gstm1, cyp2d6 and smoking. Carcinogenesis, 15(12), 2841–2845. https://doi.org/10.1093/carcin/15.12.2841

The factors that determine progression of cervical intraepithelial neoplasia (CIN) to squamous cell carcinoma (SCC) are unknown. Cigarette smoking is a risk factor, suggesting polymorphism at loci that encode carcinogenmetabolizing enzymes such as gl... Read More about Theta class glutathione s-transferase gstt1 genotypes and susceptibility to cervical neoplasia: Interactions with gstm1, cyp2d6 and smoking.

Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. (1994)
Journal Article
Warwick, A., Redman, C., Jones, P., Fryer, A., Gilford, J., Alldersea, J., & Strange, R. (1994). Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking. British journal of cancer, 70, 704 -708. https://doi.org/10.1038/bjc.1994.378

The factors that determine progression of cervical intraepithelial neoplasia (CIN) to squamous cell carcinoma (SCC) are unknown. Cigarette smoking is an independent risk factor for cervical neoplasia, suggesting that polymorphism at detoxicating enzy... Read More about Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking..