MO681PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS

Lambie; Davies

Genetic Determinants of Ultrafiltration With Peritoneal Dialysis (2022)
Presentation / Conference Contribution
Stanaway, I. B., Devuyst, O., Perl, J., Lambie, M., Morelle, J., Jarvik, G. P., Jain, A., Himmelfarb, J., Heimburger, O., Johnson, D. W., Pirkle, J. L., Robinson, B. M., Stenvinkel, P., Davies, S. J., & Mehrotra, R. (2022, November). Genetic Determinants of Ultrafiltration With Peritoneal Dialysis. Poster presented at Kidney Week, Orlando, Florida

The Bioimpedance Spectroscopy to Preserve Renal Output (BISTRO) Multicentre Randomised Controlled Trial: Quality of Life and Blood Pressure Outcomes (2022)
Presentation / Conference Contribution
Davies, S. J., Zanganeh, M., Solis-Trapala, I., Keane, D. F., Davenport, A., Wilkie, M. E., Ormandy, P., Macdonald, J. H., Dasgupta, I., Farrington, K., & Caskey, F. (2022, November). The Bioimpedance Spectroscopy to Preserve Renal Output (BISTRO) Multicentre Randomised Controlled Trial: Quality of Life and Blood Pressure Outcomes. Poster presented at ASN Kidney Week, Orlando, FL, USA

Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR (2022)
Journal Article
Lindley, E., Keane, D., Belcher, J., Fernandes Da Silva Jeffcoat, N., Davies, S., & trial investigators, B. (2022). Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR. Physiological Measurement, 43(8), Article 08NT01. https://doi.org/10.1088/1361-6579/ac80e8

OBJECTIVE: With growing recognition of the benefits of preserving residual kidney function (RKF) and use of incremental treatment regimes, the incentive to measure residual clearance in haemodialysis patients is increasing. Interdialytic urine collec... Read More about Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR.

Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle (2022)
Journal Article
Tshimologo, M., Allen, K., Coyle, D., Damery, S., Dikomitis, L., Fotheringham, J., Hill, H., Lambie, M., Phillips-Darby, L., Solis-Trapala, I., Williams, I., & Davies, S. (2022). Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle. BMJ Open, e060922 - ?. https://doi.org/10.1136/bmjopen-2022-060922

INTRODUCTION: Use of home dialysis by centres in the UK varies considerably and is decreasing despite attempts to encourage greater use. Knowing what drives this unwarranted variation requires in-depth understanding of centre cultural and organisatio... Read More about Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle.

Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study. (2022)
Journal Article
Lambie, M., Zhao, J., McCullough, K., Davies, S. J., Kawanishi, H., Johnson, D. W., Sloand, J. A., Sanabria, M., Kanjanabuch, T., Kim, Y.-L., Shen, J. I., Pisoni, R. L., Robinson, B. M., & Perl, J. (2022). Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study. Clinical Journal of the American Society of Nephrology, 17(6), 861-871. https://doi.org/10.2215/CJN.16341221

Background and objectives Quantifying contemporary peritoneal dialysis time on therapy is important for patients and providers. We describe time on peritoneal dialysis in the context of outcomes of hemodialysis transfer, death, and kidney transplanta... Read More about Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study..

International Icodextrin Use and Association with Peritoneal Membrane Function, Fluid Removal, Patient and Technique Survival (2022)
Journal Article
Davies, S., Zhao, J., McCullough, K. P., Kim, Y.-L., Wang, A. Y.-M., Badve, S. V., Mehrotra, R., Kanjanabuch, T., Kawanishi, H., Robinson, B., Pisoni, R., & Perl, J. (2022). International Icodextrin Use and Association with Peritoneal Membrane Function, Fluid Removal, Patient and Technique Survival. Kidney360, 3(5), 872-882. https://doi.org/10.34067/kid.0006922021

Key Points There are important national and center differences in the prescription of icodextrin, with the United States a clear outlier; across all countries, icodextrin was more likely to be used if membrane function tests indicated reduced ultrafi... Read More about International Icodextrin Use and Association with Peritoneal Membrane Function, Fluid Removal, Patient and Technique Survival.

Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis (2022)
Journal Article
Davies, & Lambie. (2022). Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis. Kidney International Reports, https://doi.org/10.1016/j.ekir.2022.02.016

Introduction
Transition to hemodialysis (HD) is a common outcome in peritoneal dialysis (PD), but the associated mortality risk is poorly understood. This study sought to identify rates of and risk factors for mortality after transitioning from PD t... Read More about Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis.

Spiritual well-being and its relationship with patient characteristics and other patient-reported outcomes in peritoneal dialysis patients: Findings from the PDOPPS (2022)
Journal Article
Cheawchanwattana, A., Kanjanabuch, T., Puapatanakul, P., Narenpitak, S., Halue, G., Tungsanga, K., Tatiyanupanwong, S., Lorvinitnun, P., Sritippayawan, S., Chieochanthanakij, R., Tungsanga, S., Thamcharoen, N., Pongpirul, K., Shen, J. I., Johnson, D. W., Davies, S. J., Finkelstein, F. O., Perl, J., Robinson, B., & Steering Groups, T. P. (2022). Spiritual well-being and its relationship with patient characteristics and other patient-reported outcomes in peritoneal dialysis patients: Findings from the PDOPPS. Nephrology, 27(7), 621-631. https://doi.org/10.1111/nep.14034

Background
Spiritual well-being (SWB), an individual's understanding of the meaning and purpose of life, may help patients with chronic or terminal illnesses cope with their diseases. This study aimed to assess SWB in patients on peritoneal dialysis... Read More about Spiritual well-being and its relationship with patient characteristics and other patient-reported outcomes in peritoneal dialysis patients: Findings from the PDOPPS.

Assisted peritoneal dialysis performed by caregivers and its association with patient outcomes (2022)
Journal Article
Puapatanakul, P., Kanjanabuch, T., Tungsanga, K., Cheawchanwattana, A., Tangjittrong, K., Lounseng, N., Songviriyavithaya, P., Zhao, J., Wang, A. Y.-M., Shen, J., Perl, J., Davies, S. J., Finkelstein, F. O., Johnson, D. W., & on behalf of Thailand PDOPPS Steering Groups. (2022). Assisted peritoneal dialysis performed by caregivers and its association with patient outcomes. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 42(6), 602-614. https://doi.org/10.1177/08968608221078903

Background: Although caregivers allow peritoneal dialysis (PD) patients with disabilities the opportunity to perform PD, it is crucial to clarify the safety and effectiveness of assisted PD performed by caregivers compared to self-PD. Methods: PD pat... Read More about Assisted peritoneal dialysis performed by caregivers and its association with patient outcomes.

Understand the difference between clinical measured ultrafiltrationand real ultrafiltration in peritoneal dialysis. (2021)
Journal Article
Yu, Z., Wang, Z., Wang, Q., Zhang, M., Jin, H., Ding, L., Yan, H., Huang, J., Jin, Y., Davies, S., Fang, W., & Ni, Z. (2021). Understand the difference between clinical measured ultrafiltrationand real ultrafiltration in peritoneal dialysis. BMC Nephrology, 22, Article 382. https://doi.org/10.1186/s12882-021-02589-3

BACKGROUND: It has been noticed for years that ultrafiltration (UF) is important for survival in peritoneal dialysis. On the other hand, precise and convenient UF measurement suitable for patient daily practice is not as straight forward as it is to... Read More about Understand the difference between clinical measured ultrafiltrationand real ultrafiltration in peritoneal dialysis..

Assisted peritoneal dialysis across Europe: Practice variation and factors associated with availability (2021)
Journal Article
Davies. (2021). Assisted peritoneal dialysis across Europe: Practice variation and factors associated with availability. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 533-541. https://doi.org/10.1177/08968608211049882

Background:
In Europe, the number of elderly end-stage kidney disease patients is increasing. Few of those patients receive peritoneal dialysis (PD), as many cannot perform PD autonomously. Assisted PD programmes are available in most European coun... Read More about Assisted peritoneal dialysis across Europe: Practice variation and factors associated with availability.

AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. (2021)
Journal Article
Morelle, J., Marechal, C., Yu, Z., Debaix, H., Corre, T., Lambie, M., Verduijn, M., Dekker, F., Bovy, P., Evenepoel, P., Bammens, B., Selgas, R., Bajo, M. A., Coester, A. M., Sow, A., Hautem, N., Struijk, D. G., Krediet, R. T., Balligand, J.-L., Goffin, E., …Devuyst, O. (2021). AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. New England Journal of Medicine, 385, 1570 - 1580. https://doi.org/10.1056/NEJMoa2034279

BACKGROUND: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribut... Read More about AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis..

Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. (2021)
Journal Article
Lambie, & Davies. (2021). Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. Trends in Endocrinology and Metabolism, 721 - 730. https://doi.org/10.1016/j.tem.2021.06.001

Diabetic nephropathy is highly correlated with the occurrence of other complications of type 1 diabetes (T1D) and type 2 diabetes (T2D) mellitus; for example, hypertension with cardiovascular disease (CVD) being the most frequent cause of death in pa... Read More about Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis..

Unplanned peritoneal dialysis (PD) and patient survival under Thailand “PD first” policy (2021)
Presentation / Conference Contribution
Phannajit, J., Kanjanabuch, T., Ponpirul, K., Narenpitak, S., Puapatanakul, P., Johnson, D. W., Halue, G., Lorvinidnun, P., Tangjittrong, K., Boonyakrai, C., Tatiyanupanwong, S., Purisinsith, S., Chieochanthanakij, R., Treamtrakanpon, W., Parinyasiri, U., Lounseng, N., Songviriyavithaya, P., Sritippayawan, S., Davies, S., Robinson, B. M., …PDOPPS Steering Committee, O. B. O. T. (2021, August). Unplanned peritoneal dialysis (PD) and patient survival under Thailand “PD first” policy. Presented at 19th Asian Pacific Congress of Nephrology, Virtual Congress

Background: There are conflicting results concerning the survival differences between patients with and without hemodialysis (HD) transfer (HDT). Using the Peritoneal Dialysis (PD) Outcomes and Practice Patterns Study (PDOPPS), a prospective cohort s... Read More about Unplanned peritoneal dialysis (PD) and patient survival under Thailand “PD first” policy.

The Peritoneal Dialysis Outcomes and Practice Patterns Study (2021)
Book Chapter
Stallard, B., Johnson, D. W., Perl, J., & Davies, S. J. (2021). The Peritoneal Dialysis Outcomes and Practice Patterns Study. In Applied Peritoneal Dialysis (395-410). Springer. https://doi.org/10.1007/978-3-030-70897-9_28

Background: Peritoneal dialysis (PD) technique failure remains a significant barrier to improving the outcomes for PD patients and increasing the uptake of PD worldwide. The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) has been d... Read More about The Peritoneal Dialysis Outcomes and Practice Patterns Study.

Renal staffs' understanding of patients' experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia. (2021)
Journal Article
Jones, J. E., Damery, S. L., Allen, K., Johnson, D. W., Lambie, M., Holvoet, E., & Davies, S. J. (2021). Renal staffs' understanding of patients' experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia. PloS one, 15(7), Article e0254931. https://doi.org/10.1371/journal.pone.0254931

INTRODUCTION: Many studies have explored patients' experiences of dialysis and other treatments for kidney failure. This is the first qualitative multi-site international study of how staff perceive the process of a patient's transition from peritone... Read More about Renal staffs' understanding of patients' experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia..

A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis. (2021)
Journal Article
Davies, & Lambie. (2021). A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis. Kidney International, 1101-1111. https://doi.org/10.1016/j.kint.2021.05.037

Movement of solutes across the peritoneum allows for the use of peritoneal dialysis to treat kidney failure. However, there is a large inter-individual variability in the peritoneal solute transfer rate (PSTR). Here, we tested the hypothesis that com... Read More about A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis..

PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS (2021)
Presentation / Conference Contribution
Lambie, M., Zhao, J., McCullough, K. P., Davies, S., Kawanishi, H., Johnson, D. W., Sloand, J., Sanabria, M., Kanjanabuch, T., Kim, Y.-L., Shen, J. I., Pisoni, R., Robinson, B., & Perl, J. (2021, June). PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS. Presented at 58th ERA-EDTA Congress, CityCube Berlin, Berlin, Germany

Background and Aims Comparing and interpreting regional differences in peritoneal dialysis (PD) time on therapy needs to consider differences in the rates of permanent transfer to hemodialysis (HDT), death or kidney transplantation. Here we describe... Read More about PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS.

MO680INTERNATIONAL COMPARISONS OF ICODEXTRIN PRESCRIPTION PRACTICE AND ITS ASSOCIATION WITH FLUID REMOVAL, BLOOD PRESSURE, PATIENT AND TECHNIQUE SURVIVAL* (2021)
Journal Article
Davies. (2021). MO680INTERNATIONAL COMPARISONS OF ICODEXTRIN PRESCRIPTION PRACTICE AND ITS ASSOCIATION WITH FLUID REMOVAL, BLOOD PRESSURE, PATIENT AND TECHNIQUE SURVIVAL*. Nephrology Dialysis Transplantation, https://doi.org/10.1093/ndt/gfab101.002

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Aims</jats:title> <jats:p>Icodextrin is designed to maintain ultrafiltration during the long dwell, especially when there is a risk of increased fluid reabsorption (fast peritone... Read More about MO680INTERNATIONAL COMPARISONS OF ICODEXTRIN PRESCRIPTION PRACTICE AND ITS ASSOCIATION WITH FLUID REMOVAL, BLOOD PRESSURE, PATIENT AND TECHNIQUE SURVIVAL*.

MO681PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS (2021)
Journal Article
Lambie, & Davies. (2021). MO681PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS. Nephrology Dialysis Transplantation,

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Aims</jats:title> <jats:p>Comparing and interpreting regional differences in peritoneal dialysis (PD) time on therapy needs to consider differences in the rates of permanent tran... Read More about MO681PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS.

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