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Increasing access to integrated ESKD care as part of universal health coverage. (2019)
Journal Article
Davies. (2019). Increasing access to integrated ESKD care as part of universal health coverage. Kidney International, S1 - S33. https://doi.org/10.1016/j.kint.2018.12.005

The global nephrology community recognizes the need for a cohesive strategy to address the growing problem of end-stage kidney disease (ESKD). In March 2018, the International Society of Nephrology hosted a summit on integrated ESKD care, including 9... Read More about Increasing access to integrated ESKD care as part of universal health coverage..

Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death (2019)
Journal Article
Lambie, M., Teece, L., Johnson, D. W., Petrie, M., Mactier, R., Solis-Trapala, I., …Davies, S. J. (2019). Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death. Nephrology Dialysis Transplantation, 1585-1591. https://doi.org/10.1093/ndt/gfz034

Background Risk of Encapsulating Peritoneal Sclerosis (EPS) is strongly associated with the duration of peritoneal dialysis (PD), such that patients who have been on PD for some time may consider elective transfer to haemodialysis to mitigate risk o... Read More about Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death.

International Variations in Peritoneal Dialysis Utilization and Implications for Practice (2019)
Journal Article
Davies. (2019). International Variations in Peritoneal Dialysis Utilization and Implications for Practice. American Journal of Kidney Diseases, https://doi.org/10.1053/j.ajkd.2018.12.033

In many countries, the use of peritoneal dialysis (PD) remains low despite arguments that support its greater use, including dialysis treatment away from hospital settings, avoidance of central venous catheters, and potential health economic advantag... Read More about International Variations in Peritoneal Dialysis Utilization and Implications for Practice.

Peritoneal Protein Clearance Is a Function of Local Inflammation and Membrane Area Whereas Systemic Inflammation and Comorbidity Predict Survival of Incident Peritoneal Dialysis Patients (2019)
Journal Article
Yu, Z., Lambie, M., Chess, J., Williams, A., Do, J., Topley, N., & Davies, S. J. (2019). Peritoneal Protein Clearance Is a Function of Local Inflammation and Membrane Area Whereas Systemic Inflammation and Comorbidity Predict Survival of Incident Peritoneal Dialysis Patients. Frontiers in Physiology, 10, 105 -105. https://doi.org/10.3389/fphys.2019.00105

It is not clear whether the association of increased peritoneal protein clearance with worse survival on PD is a consequence of either local or systemic inflammation or indicative of generalized endothelial dysfunction associated with comorbidity. To... Read More about Peritoneal Protein Clearance Is a Function of Local Inflammation and Membrane Area Whereas Systemic Inflammation and Comorbidity Predict Survival of Incident Peritoneal Dialysis Patients.

Transition Between Different Renal Replacement Modalities: Gaps in Knowledge and Care-The Integrated Research Initiative (2019)
Journal Article
Chan, C., Combes, G., Davies, S., Finkelstein, F., Firanek, C., Gomez, R., …Van Biesen, W. (2019). Transition Between Different Renal Replacement Modalities: Gaps in Knowledge and Care-The Integrated Research Initiative. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 39(1), 4 -12. https://doi.org/10.3747/pdi.2017.00242

Patients with end-stage kidney disease (ESKD) have different options to replace the function of their failing kidneys. The "integrated care" model considers treatment pathways rather than individual renal replacement therapy (RRT) techniques. In such... Read More about Transition Between Different Renal Replacement Modalities: Gaps in Knowledge and Care-The Integrated Research Initiative.

Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility? (2018)
Journal Article
Davies. (2018). Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?. Kidney International, 1050 -1052. https://doi.org/10.1016/j.kint.2018.09.012

Peritoneal dialysis technique survival remains challenging due to peritonitis and long-term alterations to peritoneal membrane function and integrity. Up to now, the development of less bio-incompatible dialysis solutions have not had a major impact... Read More about Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?.

The use of bioimpedance spectroscopy to guide fluid management in patients receiving dialysis (2018)
Journal Article
Tabinor, M., & Davies, S. (2018). The use of bioimpedance spectroscopy to guide fluid management in patients receiving dialysis. Current Opinion in Nephrology and Hypertension, 27(6), 406-412. https://doi.org/10.1097/MNH.0000000000000445

PURPOSE OF REVIEW To summarize the findings of recent trials and meta-analyses designed to determine whether bioimpedance spectroscopy adds value to the clinical assessment of fluid status in dialysis patients so as to achieve a normally hydrated we... Read More about The use of bioimpedance spectroscopy to guide fluid management in patients receiving dialysis.

Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport (2018)
Journal Article
Davies, & Lambie. (2018). Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport. Clinical Journal of the American Society of Nephrology, 1526-1533. https://doi.org/10.2215/%3FCJN.02380218

Background and objectives The inflammation-driven increase in peritoneal solute transport rate that occurs during long-term peritoneal dialysis is associated with higher mortality, hospitalization, and encapsulating peritoneal sclerosis. Because bio... Read More about Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport.

Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport (2018)
Journal Article
Elphick, E. H., Teece, L., Chess, J. A., Do, J., Kim, Y., Lee, H. B., …Lambie, M. (2018). Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport. Clinical Journal of the American Society of Nephrology, 13(10), 1526-1533. https://doi.org/10.2215/cjn.02380218

Background and objectives The inflammation-driven increase in peritoneal solute transport rate that occurs during long-term peritoneal dialysis is associated with higher mortality, hospitalization, and encapsulating peritoneal sclerosis. Because bi... Read More about Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport.

FP467 CHANGES IN DIALYSIS PRESCRIPTION AFFECT THE TIME COURSE OF SOLUTE TRANSPORT IN PERITONEAL DIALYSIS (2018)
Journal Article
Brenna, I., Elphick, E., Lambie, M., & Davies, S. (2018). FP467 CHANGES IN DIALYSIS PRESCRIPTION AFFECT THE TIME COURSE OF SOLUTE TRANSPORT IN PERITONEAL DIALYSIS. Nephrology Dialysis Transplantation, 33(suppl_1), i194-i194. https://doi.org/10.1093/ndt/gfy104.fp467

INTRODUCTION AND AIMS: Long term peritoneal dialysis (PD) is associated with increased peritoneal solute transport rate (PSTR), which correlates with hard outcomes. Whether different clinical approaches affect PSTR rate of increase is unclear. MET... Read More about FP467 CHANGES IN DIALYSIS PRESCRIPTION AFFECT THE TIME COURSE OF SOLUTE TRANSPORT IN PERITONEAL DIALYSIS.

Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis. (2018)
Journal Article
Tabinor, M., Elphick, E., Dudson, M., Shing Kwok, C., Lambie, M., & Davies, S. J. (2018). Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis. Scientific reports, 8, Article 4441. https://doi.org/10.1038/s41598-018-21226-y

Both overhydration and comorbidity predict mortality in end-stage kidney failure (ESKF) but it is not clear whether these are independent of one another. We undertook a systematic review of studies reporting outcomes in adult dialysis patients in whi... Read More about Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis..

United Kingdom Catheter Study - Protocol Synopsis. (2018)
Journal Article
Briggs, V., Solis-Trapala, I., Wailloo, A., McCulloch, K., Lambie, M., Caskey, F., …Wilkie, M. (2018). United Kingdom Catheter Study - Protocol Synopsis. https://doi.org/10.3747/pdi.2017.00083

BACKGROUND: High-quality peritoneal dialysis (PD) catheter insertion pathways are essential for optimal access to the therapy. Dialysis outcomes are influenced by a range of patient and center-related factors, and there is a need to better understand... Read More about United Kingdom Catheter Study - Protocol Synopsis..

A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent (2017)
Journal Article
Lambie, & Davies. (2017). A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent. Kidney International, 988-1002. https://doi.org/10.1016/j.kint.2017.03.030

Encapsulating peritoneal sclerosis (EPS) is a potentially devastating complication of peritoneal dialysis (PD). Diagnosis is often delayed due to the lack of effective and accurate diagnostic tools. We therefore examined peritoneal effluent for pot... Read More about A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent.

miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. (2017)
Journal Article
Lambie, & Davies. (2017). miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. American Journal of Pathology, 1537-1550. https://doi.org/10.1016/j.ajpath.2017.03.007

Peritoneal dialysis (PD) is a life-saving form of renal replacement therapy for those with end-stage kidney disease. Mesothelial cells (MCs) line the peritoneal cavity and help define peritoneal response to treatment-associated injury, a major reason... Read More about miR-21 Promotes Fibrogenesis in Peritoneal Dialysis..

Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients (2017)
Journal Article
Davie, S., Coyle, D., Dasgupta, I., Andronis, L., Farrington, K., Wilkie, M., …Caskey, F. (2017). Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients. BMC Nephrology, 18, Article 138. https://doi.org/10.1186/s12882-017-0554-1

BACKGROUND: Preserved residual kidney function (RKF) and normal fluid status are associated with better patient outcomes in incident haemodialysis patients. The objective of this trial is to determine whether using bioimpedance technology in prescrib... Read More about Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients.

Ethical issues in dialysis therapy (2017)
Journal Article
Jha, V., Martin, D. E., Bargman, J. M., Davies, S., Feehally, J., Finkelstein, F., …Levin, A. (2017). Ethical issues in dialysis therapy. The Lancet, 389(10081), 1851-1856. https://doi.org/10.1016/s0140-6736%2816%2932408-4

Treatment for end-stage kidney disease is a major economic challenge and a public health concern worldwide. Renal-replacement therapy poses several practical and ethical dilemmas of global relevance for patients, clinicians, and policy makers. These... Read More about Ethical issues in dialysis therapy.