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FP467 CHANGES IN DIALYSIS PRESCRIPTION AFFECT THE TIME COURSE OF SOLUTE TRANSPORT IN PERITONEAL DIALYSIS (2018)
Journal Article
Brenna, I., Elphick, E., Lambie, M., & Davies, S. (2018). FP467 CHANGES IN DIALYSIS PRESCRIPTION AFFECT THE TIME COURSE OF SOLUTE TRANSPORT IN PERITONEAL DIALYSIS. Nephrology Dialysis Transplantation, 33(suppl_1), i194-i194. https://doi.org/10.1093/ndt/gfy104.fp467

INTRODUCTION AND AIMS: Long term peritoneal dialysis (PD) is associated with increased peritoneal solute transport rate (PSTR), which correlates with hard outcomes. Whether different clinical approaches affect PSTR rate of increase is unclear. MET... Read More about FP467 CHANGES IN DIALYSIS PRESCRIPTION AFFECT THE TIME COURSE OF SOLUTE TRANSPORT IN PERITONEAL DIALYSIS.

Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis. (2018)
Journal Article
Tabinor, M., Elphick, E., Dudson, M., Shing Kwok, C., Lambie, M., & Davies, S. J. (2018). Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis. Scientific reports, 8, Article 4441. https://doi.org/10.1038/s41598-018-21226-y

Both overhydration and comorbidity predict mortality in end-stage kidney failure (ESKF) but it is not clear whether these are independent of one another. We undertook a systematic review of studies reporting outcomes in adult dialysis patients in whi... Read More about Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis..

United Kingdom Catheter Study - Protocol Synopsis. (2018)
Journal Article
Briggs, V., Solis-Trapala, I., Wailloo, A., McCulloch, K., Lambie, M., Caskey, F., …Wilkie, M. (2018). United Kingdom Catheter Study - Protocol Synopsis. https://doi.org/10.3747/pdi.2017.00083

BACKGROUND: High-quality peritoneal dialysis (PD) catheter insertion pathways are essential for optimal access to the therapy. Dialysis outcomes are influenced by a range of patient and center-related factors, and there is a need to better understand... Read More about United Kingdom Catheter Study - Protocol Synopsis..

A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent (2017)
Journal Article
Lambie, & Davies. (2017). A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent. Kidney International, 988-1002. https://doi.org/10.1016/j.kint.2017.03.030

Encapsulating peritoneal sclerosis (EPS) is a potentially devastating complication of peritoneal dialysis (PD). Diagnosis is often delayed due to the lack of effective and accurate diagnostic tools. We therefore examined peritoneal effluent for pot... Read More about A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent.

miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. (2017)
Journal Article
Lambie, & Davies. (2017). miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. American Journal of Pathology, 1537-1550. https://doi.org/10.1016/j.ajpath.2017.03.007

Peritoneal dialysis (PD) is a life-saving form of renal replacement therapy for those with end-stage kidney disease. Mesothelial cells (MCs) line the peritoneal cavity and help define peritoneal response to treatment-associated injury, a major reason... Read More about miR-21 Promotes Fibrogenesis in Peritoneal Dialysis..

Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients (2017)
Journal Article
Davie, S., Coyle, D., Dasgupta, I., Andronis, L., Farrington, K., Wilkie, M., …Caskey, F. (2017). Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients. BMC Nephrology, 18, Article 138. https://doi.org/10.1186/s12882-017-0554-1

BACKGROUND: Preserved residual kidney function (RKF) and normal fluid status are associated with better patient outcomes in incident haemodialysis patients. The objective of this trial is to determine whether using bioimpedance technology in prescrib... Read More about Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients.

Ethical issues in dialysis therapy (2017)
Journal Article
Jha, V., Martin, D. E., Bargman, J. M., Davies, S., Feehally, J., Finkelstein, F., …Levin, A. (2017). Ethical issues in dialysis therapy. The Lancet, 389(10081), 1851-1856. https://doi.org/10.1016/s0140-6736%2816%2932408-4

Treatment for end-stage kidney disease is a major economic challenge and a public health concern worldwide. Renal-replacement therapy poses several practical and ethical dilemmas of global relevance for patients, clinicians, and policy makers. These... Read More about Ethical issues in dialysis therapy.

Normalizing the peritoneal dialysis dose-have we got it right? (2016)
Journal Article
Davies, S. J. (2016). Normalizing the peritoneal dialysis dose-have we got it right?. Kidney International, 90(6), 1162 -1163. https://doi.org/10.1016/j.kint.2016.09.020

How the dialysis dose is normalized is just one of several assumptions that clinicians need to take into account when prescribing peritoneal dialysis. El-Kateb et al. confirm that estimating the volume of urea distribution is associated with signific... Read More about Normalizing the peritoneal dialysis dose-have we got it right?.

Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis (2016)
Journal Article
Davies, & Mamas. (2016). Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis. International Journal of Cardiology, 122-128. https://doi.org/10.1016/j.ijcard.2016.11.136

Background Ultrafiltration is a method used to achieve diuresis in acute decompensated heart failure (ADHF) when there is diuretic resistance, but its efficacy in other settings is unclear. We therefore conducted a systematic review and meta-analysi... Read More about Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis.

The Current State of Peritoneal Dialysis (2016)
Journal Article
Mehrotra, R., Devuyst, O., Davies, S. J., & Johnson, D. W. (2016). The Current State of Peritoneal Dialysis. Journal of the American Society of Nephrology, 27(11), 3238 -3252. https://doi.org/10.1681/ASN.2016010112

Technical innovations in peritoneal dialysis (PD), now used widely for the long-term treatment of ESRD, have significantly reduced therapy-related complications, allowing patients to be maintained on PD for longer periods. Indeed, the survival rate f... Read More about The Current State of Peritoneal Dialysis.

Patient Acceptability of the Yorkshire Dialysis Decision AID (YODDA) Booklet: A Prospective Non-Randomized Comparison Study across 6 Predialysis Services (2016)
Journal Article
Winterbottom, A. E., Gavaruzzi, T., Mooney, A., Wilkie, M., Davies, S. J., Crane, D., …Bekker, H. L. (2016). Patient Acceptability of the Yorkshire Dialysis Decision AID (YODDA) Booklet: A Prospective Non-Randomized Comparison Study across 6 Predialysis Services. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 36(4), 374-381. https://doi.org/10.3747/pdi.2014.00274

Background Patients are satisfied with their kidney care but want more support in making dialysis choices. Predialysis leaflets vary across services, with few being sufficient to enable patients’ informed decision making. We describe the acceptabili... Read More about Patient Acceptability of the Yorkshire Dialysis Decision AID (YODDA) Booklet: A Prospective Non-Randomized Comparison Study across 6 Predialysis Services.

Peritoneal Dialysate Glucose Load and Systemic Glucose Metabolism in Non-Diabetics: Results from the GLOBAL Fluid Cohort Study. (2016)
Journal Article
Lambie, M., Chess, J., Do, J., Noh, H., Lee, H., Kim, Y., …Davies, S. J. (2016). Peritoneal Dialysate Glucose Load and Systemic Glucose Metabolism in Non-Diabetics: Results from the GLOBAL Fluid Cohort Study. PloS one, 11(6), Article e0155564. https://doi.org/10.1371/journal.pone.0155564

BACKGROUND AND OBJECTIVES: Glucose control is a significant predictor of mortality in diabetic peritoneal dialysis (PD) patients. During PD, the local toxic effects of intra-peritoneal glucose are well recognized, but despite large amounts of glucose... Read More about Peritoneal Dialysate Glucose Load and Systemic Glucose Metabolism in Non-Diabetics: Results from the GLOBAL Fluid Cohort Study..

SP446THE PRESCRIPTION IN PERITONEAL DIALYSIS: INTERNATIONAL COMPARISON FROM THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS) (2016)
Journal Article
Davies, S. J., Zhao, J., Bieber, B., Perl, J., Wilkie, M., Marshall, M., …Tentori, F. (2016). SP446THE PRESCRIPTION IN PERITONEAL DIALYSIS: INTERNATIONAL COMPARISON FROM THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS). Nephrology Dialysis Transplantation, 31(suppl_1), i240-i241. https://doi.org/10.1093/ndt/gfw171.17

SP435VARIATION IN THE TREATMENT AND PREVENTION OF PERITONEAL DIALYSIS RELATED INFECTIONS: PRELIMINARY RESULTS FROM THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS) (2016)
Journal Article
Perl, J., Zhao, J., Bieber, B., Robinson, B. M., Pisoni, R. L., Tentori, F., …Johnson, D. W. (2016). SP435VARIATION IN THE TREATMENT AND PREVENTION OF PERITONEAL DIALYSIS RELATED INFECTIONS: PRELIMINARY RESULTS FROM THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS). Nephrology Dialysis Transplantation, 31(suppl_1), i236-i237. https://doi.org/10.1093/ndt/gfw171.06