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Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum (2022)
Journal Article
Anagu, L. O., Hulse, D. R., Horrocks, P. D., & Chakravorty, S. J. (2022). Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum. Molecular and Biochemical Parasitology, 111458 - 111458. https://doi.org/10.1016/j.molbiopara.2022.111458

Background
In Plasmodium falciparum the monoallelic expression of var virulence genes is regulated through epigenetic mechanisms. A study in the Gambia showed that an increase in var gene expression is associated with fever, high blood lactate with... Read More about Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum.

How can microbial interactions with the blood-brain barrier modulate astroglial and neuronal function?: How can the blood-brain barrier endothelium influence the brain? (2011)
Journal Article
Grab, D. J., Chakravorty, S. J., van der Heyde, H., & Stins, M. F. (2011). How can microbial interactions with the blood-brain barrier modulate astroglial and neuronal function?: How can the blood-brain barrier endothelium influence the brain?. Cellular Microbiology, 13(10), 1470-1478. https://doi.org/10.1111/j.1462-5822.2011.01661.x

The vascular endothelium of the blood–brain barrier (BBB) is regarded as a part of the neurovascular unit (NVU). This emerging NVU concept emphasizes the need for homeostatic signalling among the neuronal, glial and vascular endothelial cellular comp... Read More about How can microbial interactions with the blood-brain barrier modulate astroglial and neuronal function?: How can the blood-brain barrier endothelium influence the brain?.

Plasmodium falciparum icam-1-based cytoadherence-related signalling in endothelical cells (2008)
Journal Article
Jenkins, N., Wu, Y., Chakravorty, S., Kai, O., Marsh, K., & Craig, A. (2008). Plasmodium falciparum icam-1-based cytoadherence-related signalling in endothelical cells. Journal of Infection, 56(4), 299. https://doi.org/10.1016/j.jinf.2008.01.018

Background: Cytoadherence of Plasmodium falciparum infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but despite extensive information on the primary processes involved in the adhesive interactions the me... Read More about Plasmodium falciparum icam-1-based cytoadherence-related signalling in endothelical cells.

Host response to cytoadherence inPlasmodium falciparum (2008)
Journal Article
Chakravorty, S., Hughes, K., & Craig, A. (2008). Host response to cytoadherence inPlasmodium falciparum. Biochemical Society Transactions, 36(2), 221-228. https://doi.org/10.1042/bst0360221

Cytoadherence of PRBCs (Plasmodium falciparum-infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive interactions, the m... Read More about Host response to cytoadherence inPlasmodium falciparum.

Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective? (2007)
Journal Article
Chakravorty, S. J., Carret, C., Nash, G. B., Ivens, A., Szestak, T., & Craig, A. G. (2007). Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective?. International Journal for Parasitology, 37(8-9), 975-987. https://doi.org/10.1016/j.ijpara.2007.02.006

Severe malaria is associated with sequestration of Plasmodium falciparum-infected red blood cells (PRBC) in the microvasculature and elevation of intercellular adhesion molecule-1 (ICAM-1) and TNF. In vitro co-culture of human umbilical vein endothel... Read More about Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective?.

An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31 (2006)
Journal Article
Chakravorty, S. J., McGettrick, H. M., Butler, L. M., Buckley, C. D., Rainger, G. . E., & Nash, G. B. (2006). An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31. Biorheology, 43(1), 71-82

To model the later stages of neutrophil migration into tissue, we developed an assay in which human umbilical vein endothelial cells (HUVEC) were cultured on porous filters, treated with the inflammatory cytokine tumour necrosis factor-α (TNF), and t... Read More about An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31.

The effect of Plasmodium falciparum infection on expression of monocyte surface molecules (2006)
Journal Article
Jenkins, N., Chakravorty, S., Urban, B., Kai, O., Marsh, K., & Craig, A. (2006). The effect of Plasmodium falciparum infection on expression of monocyte surface molecules. Transactions of The Royal Society of Tropical Medicine and Hygiene, 100(11), 1007-1012. https://doi.org/10.1016/j.trstmh.2006.01.005

Plasmodium falciparum infection may result in severe malaria in susceptible individuals. The pathogenesis of severe disease is probably a combination of the sequestration of infected erythrocytes and overstimulation of the immune response. Monocytes... Read More about The effect of Plasmodium falciparum infection on expression of monocyte surface molecules.

Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1 (2006)
Journal Article
Dormeyer, M., Adams, Y., Kramer, B., Chakravorty, S., Tse, M. T., Pegoraro, S., …Craig, A. (2006). Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1. Antimicrobial Agents and Chemotherapy, 50(2), 724-730. https://doi.org/10.1128/aac.50.2.724-730.2006

Adhesion of Plasmodium falciparum-infected erythrocytes (IE) to host endothelium has been associated with pathology in malaria. Although the interaction with endothelial cells can be complex due to the relatively large number of host receptors availa... Read More about Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1.

PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes (2005)
Journal Article
Horrocks, P., Pinches, R. A., Chakravorty, S. J., Papakrivos, J., Christodoulou, Z., Kyes, S. A., …Newbold, C. I. (2005). PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes. Journal of Cell Science, 118(11), 2507-2518. https://doi.org/10.1242/jcs.02381

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key virulence factor for this species of human malarial parasite. PfEMP1 is expressed on the surface of infected erythrocytes (IEs) and directly mediates adhesion to a variety of... Read More about PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes.

The role of ICAM-1 in Plasmodium falciparum cytoadherence (2004)
Journal Article
Chakravorty, S. J., & Craig, A. (2005). The role of ICAM-1 in Plasmodium falciparum cytoadherence. European Journal of Cell Biology, 84(1), 15-27. https://doi.org/10.1016/j.ejcb.2004.09.002

Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1)... Read More about The role of ICAM-1 in Plasmodium falciparum cytoadherence.

Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion (2002)
Journal Article
CHAKRAVORTY, S. J., COCKWELL, P., GIRDLESTONE, J., BROOKS, C. J., & SAVAGE, C. O. S. (2002). Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion. Clinical and Experimental Immunology, 129(1), 150-159. https://doi.org/10.1046/j.1365-2249.2002.01906.x

Fractalkine (CX3CL1) is a transmembrane molecule with a CX3C chemokine domain attached to an extracellular mucin stalk which can induce both adhesion and migration of leucocytes. Mononuclear cell infiltration at renal tubular sites and associated tub... Read More about Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion.

Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines (2002)
Journal Article
Cockwell, P., Calderwood, J. W., Brooks, C. J., Chakravorty, S. J., & Savage, C. O. (2002). Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines. Nephrology Dialysis Transplantation, 17(5), 734-744. https://doi.org/10.1093/ndt/17.5.734

Background. Chemokines produced by resident renal cells promote the infiltration of leukocyte subsets. We have analysed the chemotactic responses of CD3+ peripheral blood lymphocytes (PBLs) to factors secreted by proximal tubular epithelial cells (PT... Read More about Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines.

Fractalkine expression in human renal inflammation (2001)
Journal Article
Cockwell, P., Chakravorty, S. J., Girdlestone, J., & Savage, C. O. S. (2002). Fractalkine expression in human renal inflammation. Journal of Pathology, 196(1), 85-90. https://doi.org/10.1002/path.1010

Immune and inflammatory human renal disease is associated with heavy mononuclear cell infiltration. The trafficking of these cells to extravascular sites is directed by local production of chemokines. Fractalkine is the first described cell-surface a... Read More about Fractalkine expression in human renal inflammation.

Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation (2001)
Journal Article
Chakravorty, S. J., Howie, A. J., Girdlestone, J., Gentle, D., & Savage, C. O. S. (2001). Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation. Journal of Pathology, 194(2), 239-246. https://doi.org/10.1002/path.877

The CC chemokine, monocyte chemoattractant protein-4 (MCP-4), is an important chemoattractant for monocytes and T cells. Recent data indicate a role in renal inflammation. This study has used in situ hybridization and immunohistochemical analysis of... Read More about Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation.