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All Outputs (12)

A public health emergency among young people. (2019)
Journal Article
Bush, A., Bhatt, J. M., Connett, G. J., Doull, I., Gilchrist, F. J., Grigg, J., …Sinha, I. P. (2019). A public health emergency among young people. Lancet Respiratory Medicine, 8(3), 231-233. https://doi.org/10.1016/S2213-2600%2819%2930468-0

While some countries have banned the use of e-cigarettes or vaping products altogether (eg, India), and others have strongly advised against their use (eg, Australia), in the UK, Public Health England (PHE) appears to be a lone voice in stating that... Read More about A public health emergency among young people..

A review of prednisolone prescribing for children with acute asthma in the UK (2016)
Journal Article
Gilchrist, F. J., Ahmad, A. N., Batchelor, H. K., Marriott, J. F., & Lenney, W. (2016). A review of prednisolone prescribing for children with acute asthma in the UK. Journal of Asthma, 53(6), 563 -566. https://doi.org/10.3109/02770903.2015.1118498

INTRODUCTION: Worldwide asthma guidelines recommend short courses of oral prednisolone in children with acute exacerbations generating high prescription numbers. There is a paucity of evidence to inform the optimal dose and course duration. This has... Read More about A review of prednisolone prescribing for children with acute asthma in the UK.

A systematic review of early life factors which adversely affect subsequent lung function (2016)
Journal Article
Kouzouna, A., Gilchrist, F., Ball, V., Kyriacou, T., Henderson, J., Pandyan, A., & Lenney, W. (2016). A systematic review of early life factors which adversely affect subsequent lung function. Paediatric Respiratory Reviews, 20, 67-75. https://doi.org/10.1016/j.prrv.2016.03.003

It has been known for many years that multiple early life factors can adversely affect lung function and future respiratory health. This is the first systematic review to attempt to analyse all these factors simultaneously. We adhered to strict a pri... Read More about A systematic review of early life factors which adversely affect subsequent lung function.

Developing a handheld record for patients with cystic fibrosis (2015)
Journal Article
Narayan, O., Davies, S., Tibbins, C., Rees, J., Lenney, W., & Gilchrist, F. (2015). Developing a handheld record for patients with cystic fibrosis. Patient Related Outcome Measures, 2015(6), 225 - 228. https://doi.org/10.2147/PROM.S86298

Patient handheld records (PHHRs) promote self-management and empower the holder to take a more active role in the management of their disease. They have been used successfully in improving preventative care for children and have contributed to improv... Read More about Developing a handheld record for patients with cystic fibrosis.

Bacterial distribution in the lungs of children with protracted bacterial bronchitis (2014)
Journal Article
Narang, R., Bakewell, K., Peach, J., Clayton, S., Samuels, M., Alexander, J., …Gilchrist, F. J. (2014). Bacterial distribution in the lungs of children with protracted bacterial bronchitis. PloS one, 9(9), Article e108523. https://doi.org/10.1371/journal.pone.0108523

OBJECTIVES: Flexible bronchoscopy with bronchoalveolar lavage (FB-BAL) is increasingly used for the microbiological confirmation of protracted bacterial bronchitis (PBB) in children with a chronic wet cough. At our centre, when performing FB-BAL for... Read More about Bacterial distribution in the lungs of children with protracted bacterial bronchitis.

The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom (2014)
Journal Article
Wickens-Mitchell, K. L., Gilchrist, F. J., McKenna, D., Raffeeq, P., & Lenney, W. (2014). The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom. Journal of Cystic Fibrosis, 13(5), 589-592. https://doi.org/10.1016/j.jcf.2014.01.008

Introduction The cystic fibrosis-related diabetes (CFRD) guidelines produced by the UK CF Trust differ from those used in Europe and the US. We conducted a study to establish current practice. Method Paediatric and adult questionnaires were devi... Read More about The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom.

Asthma severity and atopy: how clear is the relationship? (2006)
Journal Article
Carroll, W. D., Lenney, W., Child, F., Strange, R. C., Jones, P. W., Whyte, M. K., …Fryer, A. A. (2006). Asthma severity and atopy: how clear is the relationship?. Archives of Disease in Childhood, 91(5), 405 - 409. https://doi.org/10.1136/adc.2005.088278

BACKGROUND: The relationship between asthma severity and atopy is complex. Many studies have failed to show significant relationships between clinical severity or lung function and markers of atopic sensitisation. AIM: To determine whether increasing... Read More about Asthma severity and atopy: how clear is the relationship?.

Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. (2005)
Journal Article
Carroll, W., Lenney, W., Jones, P., Strange, R., Child, F., Whyte, M., …Fryer, A. (2005). Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35(9), 1155 - 1161. https://doi.org/10.1111/j.1365-2222.2005.02313.x

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investiga... Read More about Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families..

Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. (2005)
Journal Article
Carroll, W., Lenney, W., Child, F., Strange, R., Jones, P., & Fryer, A. (2005). Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatric Allergy and Immunology, 16(1), 32 - 39. https://doi.org/10.1111/j.1399-3038.2005.00249.x

Maternal factors are known to influence the heritability and expression of asthma and atopy. We report the association of maternal, paternal and proband GSTP1 genotype with lung function in 145 Caucasian children with asthma. GSTP1 Val105/Val105 and... Read More about Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma..