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All Outputs (7)

Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis (2024)
Journal Article
Echrish, J., Pasca, M.-I., Cabrera, D., Yang, Y., & Harper, A. G. S. (2024). Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis. Biomimetics, 9(6), Article 372. https://doi.org/10.3390/biomimetics9060372

Acute cardiovascular events result from clots caused by the rupture and erosion of atherosclerotic plaques. This paper aimed to produce a functional biomimetic hydrogel of the neointimal layer of the atherosclerotic plaque that can support thrombogen... Read More about Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis.

The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study (2023)
Journal Article
Jakobek, W., Gravino, G., Nayak, S., Yang, Y., Ranjbar, J., & Roffe, C. (in press). The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study. Interventional Neuroradiology, https://doi.org/10.1177/15910199231201518

Endovascular mechanical thrombectomy for ischaemic stroke is one of the most effective treatments. Despite the devices and techniques that have been developed, thrombi are not always successfully retrieved. The incidence of futile reperfusion after s... Read More about The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study.

Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation (2022)
Journal Article
Ranjbar, J., Yang, Y., & Harper, A. (2022). Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation. Platelets, 34(1), https://doi.org/10.1080/09537104.2022.2153823

Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicat... Read More about Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation.

The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models (2021)
Journal Article
Njoroge, W., Hernández Hernández, A. C., Idris Musa, F., Butler, R., Harper, A. G. S., & Yang, Y. (2021). The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models. Pharmaceutics, 13(3), Article 340. https://doi.org/10.3390/pharmaceutics13030340

Cardiovascular disease is a major cause of death globally. This has led to significant efforts to develop new anti-thrombotic therapies or re-purpose existing drugs to treat cardiovascular diseases. Due to difficulties of obtaining healthy human bloo... Read More about The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models.

Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults (2020)
Journal Article
Shi, R., Cai, Y., Yang, Y., Yu, D., & Qin, R. (2020). Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults. BMC Cardiovascular Disorders, 20, Article 347. https://doi.org/10.1186/s12872-020-01627-6

Background There is uncertain evidence in the dose-response association between overall physical activity levels and clustering of cardiovascular diseases modifiable risk factors (CVDMRF) in Chinese adults. This study examined the hypothesis whether... Read More about Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults.

Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury (2013)
Journal Article
Weightman, A., Jenkins, S., Pickard, M., Chari, D., & Yang, Y. (2014). Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury. Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 291-295. https://doi.org/10.1016/j.nano.2013.09.001

Non-neuronal cells of the central nervous system (CNS), termed “neuroglia,” play critical roles in neural regeneration; therefore, replacement of glial populations via implantable nanofabricated devices (providing a growth-permissive niche) is a prom... Read More about Alignment of multiple glial cell populations in 3D nanofiber scaffolds: Toward the development of multicellular implantable scaffolds for repair of neural injury.