Skip to main content

Research Repository

Advanced Search

All Outputs (87)

Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition. (2017)
Journal Article
Yang, Y. (2017). Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition. Tissue Engineering Part C: Methods, 228 - 236. https://doi.org/10.1089/ten.TEC.2017.0008

Extracellular matrix (ECM) is an essential component of tissues and provides both integrity and biological cues for cells. Collagen is one of the major proteins found within the ECM and therefore is an essential component of all engineered tissues. T... Read More about Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition..

Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy (2017)
Journal Article
Gillies, D., Gamal, W., Downes, A., Reinwald, Y., Yang, Y., El Haj, A., & Bagnaninchi, P. O. (2017). Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Proceedings of SPIE, https://doi.org/10.1117/12.2251492

There is an unmet need in tissue engineering for non-invasive, label-free monitoring of cell mechanical behaviour in their physiological environment. Here, we describe a novel optical coherence phase microscopy (OCPM) set-up which can map relative... Read More about Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy.

Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation (2017)
Journal Article
Yang, Y. (2017). Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation. Frontiers in Bioengineering and Biotechnology, 1-11. https://doi.org/10.3389/fbioe.2017.00006

Scaffolds for regenerative medicine applications should instruct cells with the appropriate signals, including biophysical stimuli such as stress and strain, to form the desired tissue. Apart from that, scaffolds, especially for load-bearing applicat... Read More about Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation.

Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment (2016)
Conference Proceeding
El Haj, A. J., Reinwald, Y., Baganinchi, P., Gamal, W., & Yang, Y. (2016). Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment.

Introduction: Monitoring the maturation of engineered tissues prior to implantation into the patient is important for defining quality and manufacturing criteria. Key properties include scaffold integrity and mechanical properties. Novel non-invasive... Read More about Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment.

Biocompatibility of biodegradable medical polymers (2016)
Book Chapter
Ozdil, D., Wimpenny, I., Aydin, H., & Yang, Y. (2017). Biocompatibility of biodegradable medical polymers. . Elsevier. https://doi.org/10.1016/b978-0-08-100372-5.00013-1

Biomaterials have various applications in the medical field; whilst biodegradable biomaterials play an important role in regenerative medicine, tissue engineering and drug delivery. In addition to conversional biocompatibility, biodegradable material... Read More about Biocompatibility of biodegradable medical polymers.

Defining a turnover index for the correlation of biomaterial degradation and cell based extracellular matrix synthesis using fluorescent tagging techniques (2016)
Journal Article
Bardsley, K., Wimpenny, I., Wechsler, R., Shachaf, Y., Yang, Y., & El Haj, A. J. (2016). Defining a turnover index for the correlation of biomaterial degradation and cell based extracellular matrix synthesis using fluorescent tagging techniques. Acta biomaterialia, 45, 133-142. https://doi.org/10.1016/j.actbio.2016.09.002

Non-destructive protocols which can define a biomaterial’s degradation and its associated ability to support proliferation and/or promote extracellular matrix deposition will be an essential in vitro tool. In this study we investigate fluorescently t... Read More about Defining a turnover index for the correlation of biomaterial degradation and cell based extracellular matrix synthesis using fluorescent tagging techniques.

Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015. (2016)
Journal Article
Yang, Y. (2016). Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015. Regenerative Medicine, 483 - 492. https://doi.org/10.2217/rme-2016-0053

This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to de... Read More about Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015..

A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall. (2016)
Journal Article
Yang, Y., Musa, F., & Harper, A. (2016). A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall. Tissue Engineering Part C: Methods, 691 - 699. https://doi.org/10.1089/ten.tec.2015.0582

Native blood vessels contain both an antiaggregatory intimal layer, which prevents platelet activation in the intact vessel, and a proaggregatory medial layer, which stimulates platelet aggregation upon vascular damage. Yet, current techniques for as... Read More about A Real-Time Monitoring System to Assess the Platelet Aggregatory Capacity of Components of a Tissue-Engineered Blood Vessel Wall..

A comparative study of skin cell activities in collagen and fibrin constructs. (2016)
Journal Article
Yang, Y. (2016). A comparative study of skin cell activities in collagen and fibrin constructs. Medical Engineering and Physics, 854 -861. https://doi.org/10.1016/j.medengphy.2016.05.017

Collagen and fibrin are widely used in tissue engineering due to their excellent biocompatibility and bioactivities that support in vivo tissue formation. These two hydrogels naturally present in different wound healing stages with different regulato... Read More about A comparative study of skin cell activities in collagen and fibrin constructs..

Accelerating and increasing nano-scaled pore formation on electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. (2016)
Journal Article
Yang, Y. (2016). Accelerating and increasing nano-scaled pore formation on electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. Journal of Biomaterials Science, Polymer Edition, 1155 - 1169. https://doi.org/10.1080/09205063.2016.1184122

Porous fibers are advantageous for filtration systems, drug delivery systems, and in the field of tissue engineering, in comparison to their non-porous counterparts. In this study, we developed a facile technique including two steps to generate poly(... Read More about Accelerating and increasing nano-scaled pore formation on electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers..

Correction: Optofluidic lens with low spherical and low field curvature aberrations (2016)
Journal Article
Zhao, H. T., Yang, Y., Chin, L. K., Chen, H. F., Zhu, W. M., Zhang, J. B., …Liu, A. Q. (in press). Correction: Optofluidic lens with low spherical and low field curvature aberrations. Lab on a Chip, 16(11), 2135-2135. https://doi.org/10.1039/c6lc90052f

Correction for ‘Optofluidic lens with low spherical and low field curvature aberrations’ by H. T. Zhao et al., Lab Chip, 2016, 16, 1617–1624. Funding information given in the Acknowledgements section is incorrect.

Flourescent, online monitoring of PLGA degradation for regenerative medicine applications (2016)
Journal Article
Yang. (2016). Flourescent, online monitoring of PLGA degradation for regenerative medicine applications. RSC advances, 44364 - 44370. https://doi.org/10.1039/C6RA04690H

Degradable polymers such as poly(lactic-co-glycolic acid) (PLGA) are frequently chosen for tissue engineering, due to their ease of production, controllable degradation rates and Food and Drug Administration (FDA) approval. Within tissue engineering... Read More about Flourescent, online monitoring of PLGA degradation for regenerative medicine applications.

OCT as a convenient tool to assess the quality and application of organotypic retinal samples (2016)
Journal Article
Gater, R., Khoshnaw, N., Nguyen, D., El Haj, A. J., & Yang, Y. (2016). OCT as a convenient tool to assess the quality and application of organotypic retinal samples. Proceedings of SPIE, 9707, https://doi.org/10.1117/12.2213509

Eye diseases such as macular degeneration and glaucoma have profound consequences on the quality of human life. Without treatment, these diseases can lead to loss of sight. To develop better treatments for retinal diseases, including cell therapies a... Read More about OCT as a convenient tool to assess the quality and application of organotypic retinal samples.

Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review (2015)
Journal Article
Yang, Y. (2015). Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, 123 - 131. https://doi.org/10.2147/JN.S70337

Restoration of function following damage to the central nervous system (CNS) is severely restricted by several factors. These include the hindrance of axonal regeneration imposed by glial scars resulting from inflammatory response to damage, and limi... Read More about Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review.

Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers (2015)
Journal Article
Kumar, D., Dale, T. P., Yang, Y., & Forsyth, N. R. (2015). Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers. Biomedical Materials, 10(6), Article 065017. https://doi.org/10.1088/1748-6041/10/6/065017

Human embryonic stem cells (hESCs) are conventionally expanded and maintained in vitro on biological substrates. Synthetic electrospun polymer nanofibers have the potential to act as non-biological substrates in the culture of hESCs. Three synthetic,... Read More about Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers.

Image analysis and quantification of tissue scaffolds (2015)
Book Chapter
Yang, Y., & Wimpenny, I. (2015). Image analysis and quantification of tissue scaffolds. In Characterisation and Design of Tissue Scaffolds (201-223). Elsevier. https://doi.org/10.1016/b978-1-78242-087-3.00009-2

If you can measure something, then you can improve it. Measurement of the structural and functional parameters of tissue-engineering scaffolds is important in the context of better scaffold design, regulation of cellular activities, and the predictio... Read More about Image analysis and quantification of tissue scaffolds.

First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST (2015)
Journal Article
Liu, F., Ding, B., Li, J., Wan, B., Shan, J., Wang, M., …the EAST Team. (2015). First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST. Nuclear Fusion, 55(12), 123022. https://doi.org/10.1088/0029-5515/55/12/123022

A 4.6 GHz lower-hybrid current drive (LHCD) system has been firstly commissioned in EAST in the 2014 campaign. The first LHCD results with 4.6 GHz show that LHW can be coupled to plasma with a low reflection coefficient, drive plasma current and plas... Read More about First results of LHCD experiments with 4.6 GHz system toward steady-state plasma in EAST.

Nano-colloid printing of functionalised PLA-b-PEO copolymers: Tailoring the surface pattern of adhesive motif and its effect on cell attachment (2015)
Journal Article
Yang. (2015). Nano-colloid printing of functionalised PLA-b-PEO copolymers: Tailoring the surface pattern of adhesive motif and its effect on cell attachment

n this study, we investigate the preparation of surface pattern of functional groups on poly(lactide) (PLA) surfaces through the controlled deposition of core-shell self-assemblies based on functionalized PLA-b-PEO amphiphilic block copolymers from s... Read More about Nano-colloid printing of functionalised PLA-b-PEO copolymers: Tailoring the surface pattern of adhesive motif and its effect on cell attachment.